Disseminated fusariosis and endogenous fungal endophthalmitis in acute lymphoblastic leukemia following platelet transfusion possibly due to transfusion-related immunomodulation.

Abstract:

BACKGROUND:To report a case of disseminated fusariosis with endogenous endophthalmitis in a patient with acute lymphoblastic leukemia. Transfusion-associated immune modulation secondary to platelet transfusion could play an important role in the pathophysiology of this case. CASE PRESENTATION:A 9 year-old male with acute lymphoblastic leukemia complicated by pancytopenia and disseminated Intravascular coagulation was given platelet transfusion. He developed disseminated fusariosis and was referred to the ophthalmology team for right endogenous endophthalmitis. The infection was controlled with aggressive systemic and intravitreal antifungals. CONCLUSION:Patients with acute lymphoblastic leukemia are predisposed to endogenous fungal endophthalmitis. Transfusion-associated immune modulation may further increase host susceptibility to such opportunistic infections.

journal_name

BMC Ophthalmol

journal_title

BMC ophthalmology

authors

Kah TA,Yong KC,Rahman RA

doi

10.1186/1471-2415-11-30

subject

Has Abstract

pub_date

2011-11-02 00:00:00

pages

30

issn

1471-2415

pii

1471-2415-11-30

journal_volume

11

pub_type

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