Abstract:
PURPOSE:To investigate the dynamic changes of hyperreflective foci (HF) in diabetic macular edema (DME) patients during the intravitreal Conbercept treatment in China. METHODS:DME Patients receiving intravitreal Conbercept (IVC) injections during the year 2016-2017 were retrospectively investigated. Thirteen patients (26 eyes) were recruited in this study. They received IVC once a month for 3 consecutive months. The number and location of HFs, the best-corrected visual acuity (BCVA) and central macular thickness (CMT) at each visit were analyzed and compared. RESULTS:After the first injection, BCVA (LogMAR) was increased from 0.75 ± 0.48 to 0.43 ± 0.24 (p < 0.05), CMT improved from 575.9 ± 191.9 to 388.2 ± 198.5 μm (p = 0.014). However, the BCVA and CMT had no statistical difference after the second and third injection as compared with those after the first injection respectively. The baseline number of HFs was 5.39 ± 4.24, 5.15 ± 5.17 and 0.88 ± 1.90 in the inner retinal, outer retinal and subretinal layer respectively. The number of HFs in these three retinal layers decreased significantly after the first injection (p = 0.0045, p < 0.0001 and p = 0.0045, respectively). However, after the second injection, only the number of HFs in the inner retinal layer experienced a further decrease. After the third injection, no statistically significant HFs changes was observed in each retinal layers. Correlation analysis showed that there was a positive significant correlation between the baseline number of HFs in the inner retina, outer retina, subretina and final BCVA (r = 0.571, p = 0.002; r = 0.464, p = 0.017; r = 0.405, p = 0.04 respectively). There was also a significant positive correlation between outer retinal HFs reduction, total retinal HFs reduction and increase of BCVA (r = 0.40, p = 0.043 and r = 0.393, p = 0.04 respectively). There were no severe ocular adverse reactions or systemic adverse events. CONCLUSIONS:Conbercept is effective and safe in the treatment of DME. HFs can act as a biomarker of poor final visual outcome.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Liu S,Wang D,Chen F,Zhang Xdoi
10.1186/s12886-019-1168-0subject
Has Abstractpub_date
2019-07-23 00:00:00pages
157issue
1issn
1471-2415pii
10.1186/s12886-019-1168-0journal_volume
19pub_type
杂志文章abstract:BACKGROUND:To gain more insight into genetic causes of cerebral visual impairment (CVI) in children and to compare ophthalmological findings between genetic and acquired forms of CVI. METHODS:The clinical data of 309 individuals (mainly children) with CVI, and a visual acuity ≤ 0.3 were analyzed for etiology and ocula...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-59
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:To report a case of late closure of idiopathic full-thickness macular hole (FTMH) after vitrectomy with the inverted internal limiting membrane (ILM) technique. CASE PRESENTATION:A 68-year-old lady with a stage IV FTMH underwent pars plana vitrectomy with 25 gauge plus transconjunctival system, ILM peeling ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0104-1
更新日期:2015-08-26 00:00:00
abstract:BACKGROUND:To examine morphological and functional results after pars plana vitrectomy (PPV) with sulfur hexafluoride (SF6) gas tamponade due to macula-on and macula-off rhegmatogenous retinal detachment (RRD) during 6 months of the follow-up. METHODS:The study included 62 eyes that underwent successful PPV with SF6 t...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1120-3
更新日期:2019-05-24 00:00:00
abstract:BACKGROUND:Ocular signs of Fabry disease can be seen in the first decade of life. METHODS:We examined the occurrence of ocular signs in 232 paediatric patients in the Fabry Outcome Survey (FOS) international registry and looked for relationships between the presence of eye findings and disease severity as measured by ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0374-2
更新日期:2016-11-16 00:00:00
abstract:BACKGROUND:Sclopetaria is a rare ophthalmic finding in trauma CASE PRESENTATION:This is a report of a patient who developed macular holes from sclopetaria induced by indirect trauma. A 22-year-old male, suffered a gunshot wound that passed behind his eyes, resulting in bilateral macular hole formation CONCLUSION:To o...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-10-6
更新日期:2010-03-19 00:00:00
abstract:BACKGROUND:Dry eye is a common problem that affects many people worldwide, reducing quality of life and impacting daily activities. A qualitative approach often used in medicine and other disciplines is used to evaluate how people with dry eye cope with this impact. METHODS:Six focus group sessions were conducted at t...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0671-z
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:To investigate the differences in refraction, accommodative factors, visual parameters, and subjective symptoms after using two types of virtual reality (VR) content with different depths of perception. METHODS:Twenty-three volunteers, who played VR games in two modes (immersive and non-immersive) for 30 mi...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01471-4
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:To investigate indocyanine green angiography (ICGA) findings in patients with long-standing Vogt-Koyanagi-Harada (VKH) disease and their correlation with disease activity on clinical examination as well as with systemic corticosteroid therapy. METHODS:Twenty-eight patients (51 eyes) with long-standing (≥6 m...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-40
更新日期:2012-08-13 00:00:00
abstract:BACKGROUND:Congenital cataract is the most frequent cause of blindness during infancy or early childhood. To date, more than 40 loci associated with congenital cataract have been identified, including at least 26 genes on different chromosomes associated with inherited cataract. This present study aimed to identify the...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0476-5
更新日期:2017-05-19 00:00:00
abstract:BACKGROUND:The present study sought to introduce clinical characteristics and stepwise surgical strategies of isolated complete cryptophthalmos, a rare, congenital ocular anomaly. CASE PRESENTATION:Retrospective, noncomparative, clinical study. Six patients with isolated complete cryptophthalmos were diagnosed at the ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1170-6
更新日期:2019-07-31 00:00:00
abstract:BACKGROUND:Combined branch retinal artery and central retinal vein occlusion is a rare condition that has been infrequently reported. This case report, aside from reporting the above-mentioned condition, highlights the importance of performing spectral domain optical coherence tomography in establishing a complete diag...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-91
更新日期:2014-07-12 00:00:00
abstract:BACKGROUND:Despite growing number of intraocular lens power calculation formulas, there is no evidence that these formulas have good predictive accuracy in pediatric, whose eyes are still undergoing rapid growth and refractive changes. This study is intended to compare the prediction error and the accuracy of predictab...
journal_title:BMC ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2415-10-20
更新日期:2010-08-25 00:00:00
abstract:BACKGROUND:An eye injury that causes no light perception (NLP) typically carries an unfavorable prognosis, and NLP because of trauma is a common indication for enucleation. With advances in vitreoretinal surgical techniques, however, the indication for enucleation is no longer determined by posttrauma NLP vision alone....
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-12-16
更新日期:2012-06-19 00:00:00
abstract:BACKGROUND:To evaluate the effects of anterior capsular opening size on deviation from predicted refraction and the effective position of the intraocular lens (ELP) in cataract surgery. METHODS:Nonrandomized clinical trial. Eighty patients (80 eyes) with simple age-related cataracts were treated from May 2018 to Septe...
journal_title:BMC ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1186/s12886-019-1068-3
更新日期:2019-02-21 00:00:00
abstract:BACKGROUND:This study compared the postoperative outcomes of 27-gauge (G) and 25-G vitrectomy performed for the treatment of idiopathic epiretinal membrane (ERM). METHODS:The study design was single center, retrospective, interventional case series. Two hundred consecutive eyes that underwent primary vitrectomy for ER...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-017-0585-1
更新日期:2017-10-10 00:00:00
abstract:BACKGROUND:To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration. CASE PRESENTATION:A 34-year-old man with thalassemia major complained of nyctalopia and decreased vision following high-dose intra...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-88
更新日期:2014-07-02 00:00:00
abstract:BACKGROUND:To investigate the accommodative loads change needed to maintain binocular fusion in patients with intermittent exotropia (IXT). METHODS:Seventeen consecutive patients with basic IXT and 15 normal controls were recruited. The WAM-5500 autorefractor (GrandSeiko, Fukuyama, Japan) was used to measure refractiv...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0260-y
更新日期:2016-06-07 00:00:00
abstract:BACKGROUND:To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. METHODS:Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC pa...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-016-0369-z
更新日期:2016-10-28 00:00:00
abstract:BACKGROUND:This case report describes a patient with chronic unilateral chemosis, likely due to treatment with amlodipine besylate. CASE PRESENTATION:A 52-year-old man visited the clinic with symptoms of foreign body sensation and puffiness in his right eye, which had persisted for 4 months. There were no other sympto...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-124
更新日期:2014-10-21 00:00:00
abstract:BACKGROUND:P66Shc is partially localised within the mitochondrial fraction. It is primarily related to the generation of mitochondrial reactive oxygen species and apoptosis. Based on previous studies, we hypothesize that in the retina, p66Shc may exist and affect the development of diabetic retinopathy. The purpose of ...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0724-3
更新日期:2018-02-27 00:00:00
abstract:BACKGROUND:To evaluate the efficacy of triple therapy consisting of single-session photodynamic therapy (PDT), intravitreal bevacizumab (IVB) and intravitreal triamcinolone (IVT) as initial pulse therapy followed by repeat intravitreal bevacizumab injections for maintenance treatment in neovascular age-related macular ...
journal_title:BMC ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2415-7-10
更新日期:2007-06-07 00:00:00
abstract::Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier function. Ocular surface pathologies, i.e. dry eye syndrome or allergic conjunctivitis, are reportedly associated ...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-015-0137-5
更新日期:2015-12-17 00:00:00
abstract:BACKGROUND:This multicentre, retro-prospective real-world study evaluated the visual, refractive and safety outcomes of a monofocal lens 1 year after implantation in cataract patients with or without pre-existing ocular pathologies. METHODS:Records from 4 centres in Germany and Sweden were reviewed to select eyes with...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01493-y
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:Iridoschisis is a rare condition that is characterized by the separation of the iris stroma into layers, with portions of the anterior layer floating freely in the aqueous humour. Here, we report three cases of iridoschisis that were complicated by either a cataract or glaucoma. Based on these cases, we spec...
journal_title:BMC ophthalmology
pub_type: 杂志文章,评审
doi:10.1186/s12886-017-0418-2
更新日期:2017-03-14 00:00:00
abstract:BACKGROUND:Adenovirus (Ad), associated with significant morbidity, has no topical treatment. A leading CTC compound (CTC-96), a Co(III) chelate, was found to have potent in vitro and in vivo antiviral efficacy against herpes viruses. In this study CTC-96 is being tested for possible anti-Adenovirus activity. METHODS:T...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-22
更新日期:2006-06-05 00:00:00
abstract:BACKGROUND:To report a case of disseminated fusariosis with endogenous endophthalmitis in a patient with acute lymphoblastic leukemia. Transfusion-associated immune modulation secondary to platelet transfusion could play an important role in the pathophysiology of this case. CASE PRESENTATION:A 9 year-old male with ac...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-11-30
更新日期:2011-11-02 00:00:00
abstract:BACKGROUND:To study the healing processes of partial thickness wounds in the adult rabbit cornea after grafting a porous collagen-glycosaminoglycan copolymer matrix (CG). METHODS:In this study, the regeneration of surgically-induced rabbit corneal defect implanted with CG was investigated. The corneal partial thicknes...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0947-3
更新日期:2018-10-25 00:00:00
abstract:BACKGROUND:To present the follow-up outcomes of a modified technique of transscleral suture fixation of posterior chamber intraocular lens (PCIOL) in eyes with inadequate capsule support. METHODS:A retrospective chart review of 21 patients underwent transscleral suture fixation of a foldable 3-looped haptics one-piece...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-019-1113-2
更新日期:2019-05-09 00:00:00
abstract:BACKGROUND:Pterygium is a condition characterized by epithelial overgrowth of the cornea, inflammatory cell infiltration and an abnormal extracellular matrix accumulation. Chronic UV exposure is considered as a pathogenic factor of this disease. Proteasome is an intracellular multi-subunit protease complex that degrade...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-018-0987-8
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:Suture exposure remains to be a potential problem of transscleral fixated posterior chamber intraocular lens (PCIOL). We report a modified technique to minimize the risk of suture exposure for the transscleral fixation of PCIOL. METHODS:The modified surgical technique is as following: at first, two 3 mm × 4...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-015-0118-8
更新日期:2015-10-02 00:00:00