Abstract:
BACKGROUND:Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid administration. The inflammatory swelling of the intraorbital muscles can lead to pressure-induced damage of the optic nerve. Orbital decompression surgery is a therapeutic option for these patients with varying success. Other symptoms like the extreme malposition of the ocular globe are poorly addressed by decompression surgery and demand for different therapeutic approaches. CASE PRESENTATION:Presented is the case of a 46-year old patient with an acute exacerbation of Graves' ophthalmopathy. Clinically apparent was a convergent strabismus fixus with severe hypotropia of both eyes. The patient suffered from attacks of heavy retrobulbar pain and eyesight deteriorated dramatically. Since neither systemic glucocorticoid therapy nor orbital decompression surgery had helped to halt the progress of the disease, a decision was made in favour of the surgical release and repositioning of the inferior and medial rectus muscle as a final therapeutic option. Surgery of both eyes was performed consecutively within one week. Detailed descriptions and illustrations of the surgical steps and treatment outcome are provided supplemented by a discussion of the current literature. CONCLUSIONS:Graves' Ophthalmopathy is a variant and therapeutically challenging disease. Exceptional courses of the disease call for therapeutic approaches off the beaten track. Surgical extraocular muscle repositioning, which has not been described before in the context of Graves' Ophthalmopathy, proved to be effective in improving the patient's eyesight and quality of life. Furthermore, we regard the measurement of extraocular muscle volume as a valuable method to monitor the course of Graves' Ophthalmopathy.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Rau A,Klopfer M,Rommel N,Rau-Fornefeld M,Kolk Adoi
10.1186/s12886-018-0718-1subject
Has Abstractpub_date
2018-02-27 00:00:00pages
56issue
1issn
1471-2415pii
10.1186/s12886-018-0718-1journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Since the normative value of the retinal macular thickness is undocumented in the Middle East, the aim of this work is to assess the normative values of the macular thickness in healthy eyes in a Middle Eastern population and its relationship with age, sex, and laterality. METHODS:One hundred sixteen indivi...
journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/s12886-020-01391-3
更新日期:2020-04-07 00:00:00
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pub_type: 杂志文章
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journal_title:BMC ophthalmology
pub_type: 临床试验,杂志文章
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更新日期:2019-02-21 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-26 00:00:00
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-6-27
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journal_title:BMC ophthalmology
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journal_title:BMC ophthalmology
pub_type: 杂志文章
doi:10.1186/1471-2415-14-59
更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:BMC ophthalmology
pub_type: 杂志文章,meta分析,评审
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