Dolosigranulum pigrum keratitis: a three-case series.

Abstract:

BACKGROUND:Dolosigranulum pigrum is a commensal inhabitant of the upper respiratory tract suspected to be responsible for ocular infections but no well-described case of D. pigrum corneal infection has been reported. Herein culture and PCR-sequencing-based investigations of corneal scraping specimens confirmed D. pigrum keratitis in three patients. CASE PRESENTATION:Three elderly patients presented with unilateral keratitis. None was a corneal-contact lens wearer, one had previous cataract surgery and another suffered rheumatoid arthritis sicca syndrome. Culturing the corneal scraping specimen was positive for two cases and PCR-sequencing of bacterial 16S rDNA in the presence of negative controls identified D. pigrum in three cases. The two D. pigrum isolates were in-vitro susceptible to penicillin G, amoxicillin, doxycycline, rifampicin and gentamicin. In all cases, surgical treatment of corneal thinning was necessary, but corneal perforation occurred in two cases despite intensive antimicrobial treatment with ticarcillin, gentamicin and vancomycin or levofloxacin eye drops leading to enucleation in one case. CONCLUSIONS:D. pigrum is the likely cause of corneal infection in three patients, with effective antibiotic treatment in two patients.

journal_name

BMC Ophthalmol

journal_title

BMC ophthalmology

authors

Sampo M,Ghazouani O,Cadiou D,Trichet E,Hoffart L,Drancourt M

doi

10.1186/1471-2415-13-31

subject

Has Abstract

pub_date

2013-07-10 00:00:00

pages

31

issn

1471-2415

pii

1471-2415-13-31

journal_volume

13

pub_type

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