Abstract:
BACKGROUND:Retinal vein occlusion (RVO) is a common retinal venous disorder that causes vision loss. No specific therapy has been developed. Controversy exists regarding two treatments: intravitreal dexamethasone implants and anti-vascular endothelial growth factor (VEGF). The goal of this study is to compare the effectiveness and safety of dexamethasone implants and anti-VEGF treatment for RVO. METHODS:The PubMed, Embase, and Cochrane Library databases were searched for studies comparing dexamethasone implants with anti-VEGF in patients with RVO. Best-corrected visual acuity (BCVA), central subfield thickness (CST), intraocular pressure changes, conjunctival haemorrhage, reduced VA, and macular oedema were extracted from the final included studies. RevMan 5.3 was used to conduct the quantitative analysis and bias assessment. RESULTS:Four randomised controlled trials assessing 969 eyes were included. The anti-VEGF treatment showed better BCVA improvement (mean difference [MD] = - 10.59, P < 0.00001) and more CST decrease (MD = - 86.71 μm, P = 0.02) than the dexamethasone implants. However, the dexamethasone implants required fewer injections. As for adverse effects, the dexamethasone implants showed significantly higher intraocular pressure (IOP) and more cataracts than the anti-VEGF treatment. No significant differences were found in conjunctival haemorrhage, reduced VA, and macular oedema. CONCLUSIONS:Anti-VEGF treatment showed better functional and anatomical improvement with less risk of IOP elevation and cataract formation compared to dexamethasone implants. Thus, anti-VEGF treatment is the first choice for treating RVO patients.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Gao L,Zhou L,Tian C,Li N,Shao W,Peng X,Shi Qdoi
10.1186/s12886-018-1016-7subject
Has Abstractpub_date
2019-01-08 00:00:00pages
8issue
1issn
1471-2415pii
10.1186/s12886-018-1016-7journal_volume
19pub_type
杂志文章,meta分析abstract:PURPOSE:More than 3 million cataract extractions are undertaken in India annually. Almost 60% of these operations are intracapsular Cataract Extractions. The subsequent optical correction is provided by aphakic spectacles. The aim of this study is to assess visual outcome and perceived benefits of post-operative use of...
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pub_type: 杂志文章,多中心研究
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更新日期:2018-08-01 00:00:00
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更新日期:2014-07-02 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2010-04-29 00:00:00
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更新日期:2021-01-06 00:00:00
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更新日期:2013-10-16 00:00:00
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pub_type: 杂志文章,多中心研究
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