Abstract：
:Although the mechanism of dry eye disease is not clearly understood, it is certain that inflammation and the immune response play a major role in determining the health of the ocular surface in dry eye patients. Accurate ocular surface characterization during the early stages of dry eye disease is critical for successful treatment, because there exists no single standard, objective test to diagnose the early phase of dry eye disease. The treatment target should be direct to prevent the perpetuation of chronic inflammation and immune responses. Numerous studies have categorized dry eye disease as an autoimmune-related inflammatory disease. However, relatively little is known about how innate immune mechanisms act following a local insult, why some patients are particularly vulnerable, and why local inflammation fails to resolve in these patients. Within this review, particular attention will be given to the very early events and corresponding defense mechanism in dry eye disease. The transition from innate to adaptive immunity will also be discussed.
journal_name
BMC Ophthalmoljournal_title
BMC ophthalmologyauthors
Na KS,Hwang KY,Lee HS,Chung SH,Mok JW,Joo CKdoi
10.1186/s12886-015-0133-9subject
Has Abstractpub_date
2015-12-17 00:00:00pages
159issn
1471-2415pii
10.1186/s12886-015-0133-9journal_volume
15 Suppl 1pub_type
杂志文章abstract：BACKGROUND:Because latanoprost and the original formulation of travoprost that included benzalkonium chloride (BAK) have been shown to be similar with regard to tolerability, we compared initial topical intraocular pressure (IOP)-lowering medication change rates in patients newly treated with latanoprost or travoprost-...
journal_title：BMC ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1186/1471-2415-11-13
更新日期：2011-06-13 00:00:00
abstract：BACKGROUND:To examine morphological and functional results after pars plana vitrectomy (PPV) with sulfur hexafluoride (SF6) gas tamponade due to macula-on and macula-off rhegmatogenous retinal detachment (RRD) during 6 months of the follow-up. METHODS:The study included 62 eyes that underwent successful PPV with SF6 t...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1120-3
更新日期：2019-05-24 00:00:00
abstract：BACKGROUND:To evaluate the relationships between Reichert Ocular Response Analyzer (ORA) parameters corneal hysteresis (CH) and corneal response factor (CRF) and ocular dimensions, age and intraocular pressure. METHODS:Two hundred and twelve eyes of 212 participants with no ocular pathology had CH and CRF measured wit...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-11
更新日期：2014-01-30 00:00:00
abstract：BACKGROUND:The use of capsular tension ring (CTR) implantation to treat cataract patients with weak zonules is still controversial. The aim of this study was to examine the effects of CTR implantation on capsular stability after phacoemulsification in patients with weak zonules, especially patients who have undergone p...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01772-8
更新日期：2021-01-07 00:00:00
abstract：:Ophthalmologists and researchers in ophthalmology understand what a rapidly evolving field ophthalmology is, and that to conduct good research it is essential to use the latest and best methods. In outcomes research, one modern initiative has been to conduct holistic measurement of outcomes inclusive of the patient's ...
journal_title：BMC ophthalmology
pub_type： 社论,评审
doi：10.1186/1471-2415-6-25
更新日期：2006-06-15 00:00:00
abstract：BACKGROUND:Stress-induced activation of the sympathetic nervous system leads to a cascade of metabolic reactions. Emotional stress is a more specific form of stress in which the stressor is a psychological response to a situation subjectively perceived as traumatic. Stress hormones can have a wide range of effects on t...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-019-1075-4
更新日期：2019-03-08 00:00:00
abstract：BACKGROUND:This study sought to identify factors associated with retinal detachment and retreatment of aggressive posterior retinopathy of prematurity (APROP) initially treated with intravitreal ranibizumab (IVR) injection as well as the efficacy of IVR treatment. METHODS:This was a retrospective study. A total of 83 ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0815-1
更新日期：2018-06-26 00:00:00
abstract：BACKGROUND:A 23 year old white male with a history of social and behavioural problems attempted to blind himself chemically, with alcohol, and mechanically, with a razor blade. METHODS:Observational case report of a patient who self-inflicted bilateral scleral lacerations with a razor blade, after losing his job. RES...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-9-14
更新日期：2009-12-10 00:00:00
abstract：BACKGROUND:Characterization of the neuro-glial profile of cells growing out of human idiopathic epiretinal membranes (iERMs) and testing their proliferative and pluripotent properties ex vivo is needed to better understand the pathogenesis of their formation. METHODS:iERMs obtained during uneventful vitrectomies were ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-165
更新日期：2014-12-23 00:00:00
abstract：BACKGROUND:Currently, various types of toric intraocular lenses (IOL) have been manufactured and can be divided into three types according to the location of correction component; front-toric IOL (correction on anterior IOL surface), back-toric IOL (correction on posterior IOL surface), and bi-toric IOL (correction on ...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01439-4
更新日期：2020-04-28 00:00:00
abstract：BACKGROUND:To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. METHODS:This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-017-0481-8
更新日期：2017-06-12 00:00:00
abstract：BACKGROUND:The presence of an intraocular cilium is very rare and the response of the eye to the cilium is variable. We present the case of a patient with a cilium found in the vitreous cavity during vitrectomy for rhegmatogenous retinal detachment 40 years following penetrating eye injury. To our knowledge, this is th...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-015-0010-6
更新日期：2015-03-12 00:00:00
abstract：BACKGROUND:Retinal detachment is a disorder of the eye in which sensory retina separates from the retinal pigment epithelium (RPE) due to accumulation of fluid in subretinal space. Pharmacological stimulation of fluid reabsorption from subretinal space to choroid across the RPE has been suggested as a treatment strateg...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-11-33
更新日期：2011-11-15 00:00:00
abstract：BACKGROUND:Idiopathic orbital pseudotumour is rare in children. We report a case of bilateral paediatric idiopathic orbital pseudotumour and review the characteristics of this case. CASE PRESENTATION:A 14-year-old female patient presented at our Department of Pulmonary and Critical Care Medicine (PCCM) with complaints...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01718-0
更新日期：2020-11-16 00:00:00
abstract：BACKGROUND:To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration. CASE PRESENTATION:A 34-year-old man with thalassemia major complained of nyctalopia and decreased vision following high-dose intra...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-88
更新日期：2014-07-02 00:00:00
abstract：BACKGROUND:Iridoschisis is a rare condition that is characterized by the separation of the iris stroma into layers, with portions of the anterior layer floating freely in the aqueous humour. Here, we report three cases of iridoschisis that were complicated by either a cataract or glaucoma. Based on these cases, we spec...
journal_title：BMC ophthalmology
pub_type： 杂志文章,评审
doi：10.1186/s12886-017-0418-2
更新日期：2017-03-14 00:00:00
abstract：BACKGROUND:Lateralization of horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) is very important for successful repositioning. The directions of lying-down nystagmus (LDN) and head-bending nystagmus (HBN) have been used as ancillary findings to identify the affected sites. This retrospective...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-136
更新日期：2014-11-20 00:00:00
abstract：BACKGROUND:Pterygium is a condition characterized by epithelial overgrowth of the cornea, inflammatory cell infiltration and an abnormal extracellular matrix accumulation. Chronic UV exposure is considered as a pathogenic factor of this disease. Proteasome is an intracellular multi-subunit protease complex that degrade...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0987-8
更新日期：2018-12-18 00:00:00
abstract：BACKGROUND:This case report describes a patient with chronic unilateral chemosis, likely due to treatment with amlodipine besylate. CASE PRESENTATION:A 52-year-old man visited the clinic with symptoms of foreign body sensation and puffiness in his right eye, which had persisted for 4 months. There were no other sympto...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-124
更新日期：2014-10-21 00:00:00
abstract：BACKGROUND:The repertoire of free-living protozoa in contact lens solutions is poorly known despite the fact that such protozoa may act as direct pathogens and may harbor intra-cellular pathogens. METHODS:Between 2009 and 2014, the contact lens solutions collected from patients presenting at our Ophthalmology Departme...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0370-6
更新日期：2016-10-29 00:00:00
abstract：BACKGROUND:Endogenous endophthalmitis could lead to a devastating outcome without a prompt and appropriate management. We report a case of advanced endogenous Klebsiella pneumoniae endophthalmitis with extensive subretinal abscess that was successfully treated with a vitrectomy. CASE PRESENTATION:A systemically well 6...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0908-x
更新日期：2018-09-05 00:00:00
abstract：BACKGROUND:To study the value and safety of aqueous humor polymerase chain reaction (PCR) analysis for Herpes simplex, varicella zoster, cytomegalovirus, Epstein-Barr virus and Toxoplasma gondii in patients with uveitis. METHODS:Records of 45 consecutive patients with anterior and posterior uveitis who underwent AC pa...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-016-0369-z
更新日期：2016-10-28 00:00:00
abstract：BACKGROUND:To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. METHODS:A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conduct...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0737-y
更新日期：2018-03-05 00:00:00
abstract：BACKGROUND:To explore the molecular genetic cause of a four-generation autosomal dominant congenital cataract family in China. METHODS:Targeted region sequencing was performed to screen for the potential mutation, and Sanger sequencing was used to confirm the mutation. The homology model was constructed to identify th...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01725-1
更新日期：2020-11-20 00:00:00
abstract：BACKGROUND:Monocular infantile blindness may be associated with bilateral horizontal nystagmus, a subtype of fusion maldevelopment nystagmus syndrome (FMNS). Patients often adopt a significant anomalous head posture (AHP) towards the fixing eye in order to dampen the nystagmus. This clinical entity has also been report...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/1471-2415-14-137
更新日期：2014-11-20 00:00:00
abstract：BACKGROUND:To study the healing processes of partial thickness wounds in the adult rabbit cornea after grafting a porous collagen-glycosaminoglycan copolymer matrix (CG). METHODS:In this study, the regeneration of surgically-induced rabbit corneal defect implanted with CG was investigated. The corneal partial thicknes...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-0947-3
更新日期：2018-10-25 00:00:00
abstract：BACKGROUND:Diabetic macular edema (DME) can be treated with different alternatives, among them Dexamethasone intravitreal implant 0.7 mg (DEX 0.7) has demonstrated that may improve both central macular thickness (CMT) and best corrected visual acuity (BCVA). This study aimed to evaluate the effect of the intravitreal d...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-018-1022-9
更新日期：2019-01-11 00:00:00
abstract：BACKGROUND:There is no generally accepted medical or surgical treatment to stop the progressive course of retinitis pigmentosa. Previous studies have suggested lutein as a potential treatment with positive effects on macular pigment density. The objective of this study was to examine the effect of lutein supplementatio...
journal_title：BMC ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1186/1471-2415-6-23
更新日期：2006-06-07 00:00:00
abstract：BACKGROUND:To report a case of branch retinal artery occlusion (BRAO) secondary to high-altitude exposure and diabetic retinopathy (DR), and to characterize the retinal changes before and after hyperbaric oxygen (HBO) treatment. CASE PRESENTATION:We present a case of a 42-year-old man with DR who travelled to Tibet (i...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-01563-1
更新日期：2020-07-11 00:00:00
abstract：BACKGROUND:Retinitis pigmentosa (RP) is a kind of inherited retinal degenerative diseases characterized by the progressive loss of photoreceptors. RP has been a conundrum without satisfactory countermeasures in clinic until now. Acetaldehyde dehydrogenase 2 (ALDH2), a major enzyme involved in aldehyde detoxification, h...
journal_title：BMC ophthalmology
pub_type： 杂志文章
doi：10.1186/s12886-020-1330-8
更新日期：2020-02-18 00:00:00
