BARD1 mediates TGF-β signaling in pulmonary fibrosis.

abstract：BACKGROUND:Pulmonary neuroendocrine cells (PNEC) are specialized epithelial cells that are thought to play important roles in lung development and airway function. PNEC occur either singly or in clusters called neuroepithelial bodies. Our aim was to characterize the three dimensional morphology of PNEC, their distribut...

journal_title：Respiratory research

authors： Weichselbaum M,Sparrow MP,Hamilton EJ,Thompson PJ,Knight DA

更新日期：2005-10-10 00:00:00

abstract：BACKGROUND:Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popula...

journal_title：Respiratory research

authors： Dinh PC,Cores J,Hensley MT,Vandergriff AC,Tang J,Allen TA,Caranasos TG,Adler KB,Lobo LJ,Cheng K

更新日期：2017-06-30 00:00:00

abstract：BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...

journal_title：Respiratory research

authors： Vagaggini B,Bartoli ML,Cianchetti S,Costa F,Bacci E,Dente FL,Di Franco A,Malagrinò L,Paggiaro P

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Exposure to cigarette smoke is considered a major risk factor for the development of lung diseases, since its causative role has been assessed in the induction and maintenance of an inflamed state in the airways. Lung fibroblasts can contribute to these processes, due to their ability to produce proinflammat...

journal_title：Respiratory research

authors： La Rocca G,Anzalone R,Magno F,Farina F,Cappello F,Zummo G

更新日期：2007-03-12 00:00:00

abstract：BACKGROUND:Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and mechanisms of respiratory tract injuries caused by chronic exposure to air pollution remain to be clar...

journal_title：Respiratory research

authors： Yoshizaki K,Brito JM,Moriya HT,Toledo AC,Ferzilan S,Ligeiro de Oliveira AP,Machado ID,Farsky SH,Silva LF,Martins MA,Saldiva PH,Mauad T,Macchione M

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...

journal_title：Respiratory research

authors： Yang Q,Soltis AR,Sukumar G,Zhang X,Caohuy H,Freedy J,Dalgard CL,Wilkerson MD,Pollard HB,Pollard BS

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Recent studies have indicated the presence of multipotent mesenchymal stromal cells (MSCs) in human lung diseases. Excess airway smooth muscle, myofibroblasts and activated fibroblasts have each been noted in asthma, suggesting that mesenchymal progenitor cells play a role in asthma pathogenesis. We therefor...

journal_title：Respiratory research

authors： Bentley JK,Popova AP,Bozyk PD,Linn MJ,Baek AE,Lei J,Goldsmith AM,Hershenson MB

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-...

journal_title：Respiratory research

authors： Hodge G,Jersmann H,Tran HB,Holmes M,Reynolds PN,Hodge S

更新日期：2015-01-09 00:00:00

abstract：BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

journal_title：Respiratory research

authors： Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:To identify COPD associated gene susceptibility and lung function in a longitudinal cohort including COPD and subjects who were at risk for developing COPD, and to replicate this in two cross-sectional and longitudinal populations in Chinese Han population. METHODS:Three cohorts were recruited in this study...

journal_title：Respiratory research

authors： Xie J,Wu H,Xu Y,Wu X,Liu X,Shang J,Zhao J,Zhao J,Wang J,Dela Cruz CS,Xiong W,Xu Y

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

journal_title：Respiratory research

authors： Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

更新日期：2009-11-25 00:00:00

abstract：BACKGROUND:Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role in the physiopathology of both conditions. To date, circulating miRNA expression has been studied...

journal_title：Respiratory research

authors： Lázaro J,Clavería P,Cabrejas C,Fernando J,Daga B,Ordoñez B,Segura S,Sanz-Rubio D,Marín JM

更新日期：2020-02-04 00:00:00

abstract：:Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several k...

journal_title：Respiratory research

authors： Qvist T,Pressler T,Høiby N,Katzenstein TL

更新日期：2014-04-11 00:00:00

abstract：:Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised ...

journal_title：Respiratory research

authors： Kołodziej M,de Veer MJ,Cholewa M,Egan GF,Thompson BR

更新日期：2017-05-17 00:00:00

abstract：BACKGROUND:The prevalence and incidence of sarcoidosis varies worldwide. We estimated the prevalence and incidence of sarcoidosis in Korea using nationwide claims data from the Korean Health Insurance Review and Assessment Service. METHODS:Cases of sarcoidosis were identified for any visit between 2007 to 2016 that li...

journal_title：Respiratory research

authors： Yoon HY,Kim HM,Kim YJ,Song JW

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. METHODS:Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hem...

journal_title：Respiratory research

authors： Zeng L,Yang XT,Li HS,Li Y,Yang C,Gu W,Zhou YH,Du J,Wang HY,Sun JH,Wen DL,Jiang JX

更新日期：2016-12-07 00:00:00

abstract：:Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-ce...

journal_title：Respiratory research

authors： Nadel JA

更新日期：2001-01-01 00:00:00

abstract：:The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been co...

journal_title：Respiratory research

authors： Gao J,Liu JQ,Wen HJ,Liu H,Hu WD,Han X,Li CX,Wang XJ

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:Colonization of the airways with potential pathogenic bacteria is observed in a number of chronic respiratory diseases, such as COPD or cystic fibrosis. Infections with respiratory viruses are known triggers of exacerbations of these diseases. We here investigated if pre-exposure to bacteria alters the respo...

journal_title：Respiratory research

authors： Bellinghausen C,Gulraiz F,Heinzmann AC,Dentener MA,Savelkoul PH,Wouters EF,Rohde GG,Stassen FR

更新日期：2016-06-03 00:00:00

abstract：BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

journal_title：Respiratory research

authors： Ren Z,Hu Y,Xu L

更新日期：2019-10-16 00:00:00

abstract：OBJECTIVE:We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). METHODS:A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and dist...

journal_title：Respiratory research

authors： Mao S,Wu L,Shi W

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:The receptor for advanced glycation end products (RAGE) is a multiligand signal transduction receptor that can initiate and perpetuate inflammation. Its soluble isoform (sRAGE) acts as a decoy receptor for RAGE ligands, and is thought to afford protection against inflammation. With the present study, we aime...

journal_title：Respiratory research

authors： Miniati M,Monti S,Basta G,Cocci F,Fornai E,Bottai M

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in utero exposure to SHS at critical stages of fetal development, results in altered lung responses and...

journal_title：Respiratory research

authors： Noël A,Xiao R,Perveen Z,Zaman H,Le Donne V,Penn A

更新日期：2017-06-27 00:00:00

abstract：RESEARCH QUESTION:There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment. PATIENTS A...

journal_title：Respiratory research

authors： Pastre J,Barnett S,Ksovreli I,Taylor J,Brown AW,Shlobin OA,Ahmad K,Khangoora V,Aryal S,King CS,Nathan SD

更新日期：2021-01-06 00:00:00

abstract：RATIONALE:Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly r...

journal_title：Respiratory research

authors： Malur A,Kavuru MS,Marshall I,Barna BP,Huizar I,Karnekar R,Thomassen MJ

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:Tracheal epithelial cells are anchored to a dynamic basement membrane that contains a variety of extracellular matrix proteins including collagens and laminins. During development, wound repair and disease of the airway epithelium, significant changes in extracellular matrix proteins may directly affect cell...

journal_title：Respiratory research

authors： Isakson BE,Olsen CE,Boitano S

更新日期：2006-08-02 00:00:00

abstract：:Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host...

journal_title：Respiratory research

authors： Kesic MJ,Hernandez M,Jaspers I

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Allergen-containing subpollen particles (SPP) are released from whole plant pollen upon contact with water or even high humidity. Because of their size SPP can preferentially reach the lower airways where they come into contact with surfactant protein (SP)-D. Our previous work demonstrated that SP-D increase...

journal_title：Respiratory research

authors： Schleh C,Erpenbeck VJ,Winkler C,Lauenstein HD,Nassimi M,Braun A,Krug N,Hohlfeld JM

更新日期：2010-06-22 00:00:00

abstract：BACKGROUND:Long-term lung allograft survival is limited by bronchiolitis obliterans syndrome (BOS). Mannose binding lectin (MBL) belongs to the innate immune system, participates in complement activation, and may predispose to graft rejection. We investigated mannose binding (MBL) during cold ischemia and in tissue sam...

journal_title：Respiratory research

authors： Budd SJ,Aris RM,Medaiyese AA,Tilley SL,Neuringer IP

更新日期：2012-07-04 00:00:00

abstract：:The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...

journal_title：Respiratory research

authors： Nathell L,Nathell M,Malmberg P,Larsson K

更新日期：2007-12-04 00:00:00