Role of epidermal growth factor receptor activation in regulating mucin synthesis.


:Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this occurs via cell multiplication. The mechanisms that determine which pathway is chosen are critical but largely unknown. Although no effective therapy exists for hypersecretion at present, the EGFR cascade suggests methods for effective therapeutic intervention.


Respir Res


Respiratory research


Nadel JA





Has Abstract


2001-01-01 00:00:00












  • The current position of surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis.

    abstract::A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively spec...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Kaarteenaho R

    更新日期:2013-04-15 00:00:00

  • SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation.

    abstract:BACKGROUND:It has been confirmed that NF-κB p65 signaling pathway is involved in the regulation of alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome (ARDS). Whether SN50, a NF-κB cell permeable inhibitor, could attenuate alveolar hypercoagulation and fibrinolysis inhibition in...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wu Y,Wang Y,Liu B,Cheng Y,Qian H,Yang H,Li X,Yang G,Zheng X,Shen F

    更新日期:2020-05-27 00:00:00

  • A predictive scoring instrument for tuberculosis lost to follow-up outcome.

    abstract:BACKGROUND:Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究


    authors: Rodrigo T,Caylà JA,Casals M,García-García JM,Caminero JA,Ruiz-Manzano J,Blanquer R,Vidal R,Altet N,Calpe JL,Penas A,Working Group on Completion of Tuberculosis Treatment in Spain.

    更新日期:2012-09-02 00:00:00

  • Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.

    abstract:BACKGROUND:Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. METHODS:The life status of a cohort of 6031 ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: de Marco R,Locatelli F,Cazzoletti L,Bugianio M,Carosso A,Marinoni A

    更新日期:2005-08-16 00:00:00

  • Factors associated with change in exacerbation frequency in COPD.

    abstract:BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or zero exacerbations per year. Although most patients do not change category from year to year, some wi...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Donaldson GC,Müllerova H,Locantore N,Hurst JR,Calverley PM,Vestbo J,Anzueto A,Wedzicha JA

    更新日期:2013-07-30 00:00:00

  • Metformin attenuates lung fibrosis development via NOX4 suppression.

    abstract:BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

    更新日期:2016-08-30 00:00:00

  • Reduced HDAC2 in skeletal muscle of COPD patients.

    abstract:BACKGROUND:Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The aim of this study was to investigate the role of histone deacetylases(HDAC) in skeletal muscle weak...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: To M,Swallow EB,Akashi K,Haruki K,Natanek SA,Polkey MI,Ito K,Barnes PJ

    更新日期:2017-05-19 00:00:00

  • Weighted Epworth sleepiness scale predicted the apnea-hypopnea index better.

    abstract:BACKGROUND:The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight in prediction in clinical practice. Would awarding different item-scores to the four scales of ESS it...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guo Q,Song WD,Li W,Zeng C,Li YH,Mo JM,Lü ZD,Jiang M

    更新日期:2020-06-12 00:00:00

  • Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion.

    abstract:BACKGROUND:Pleural effusion (PE) can be divided into benign pleural effusion (BPE) and malignant pleural effusion (MPE). There is no consensus on the identification of lung cancer-associated MPE using the optimal cut-off levels from five common tumor biomarkers (CEA, CYFRA 21-1, CA125, SCC-Ag, and NSE). Therefore, we a...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zhang H,Li C,Hu F,Zhang X,Shen Y,Chen Y,Li F

    更新日期:2020-10-29 00:00:00

  • Isolation and characterization of extracellular vesicles from Broncho-alveolar lavage fluid: a review and comparison of different methods.

    abstract::Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on their size, surface marker, and method of release from the host cell. Recently, EVs have become of interest i...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Carnino JM,Lee H,Jin Y

    更新日期:2019-10-30 00:00:00

  • Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression.

    abstract:BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析


    authors: Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

    更新日期:2019-08-16 00:00:00

  • Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease.

    abstract:RATIONALE:Smoking-induced chronic obstructive pulmonary disease (COPD) is associated with acquired systemic cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. Recently, sweat evaporimetry has been shown to efficiently measure β-adrenergic sweat rate and specifically quantify CFTR function in the se...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Courville CA,Tidwell S,Liu B,Accurso FJ,Dransfield MT,Rowe SM

    更新日期:2014-02-25 00:00:00

  • A 3D epithelial-mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment.

    abstract:BACKGROUND:The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling process in wound healing and disease development. However, the involvement of bronchial epithelial ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Ishikawa S,Ishimori K,Ito S

    更新日期:2017-11-22 00:00:00

  • Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients.

    abstract:BACKGROUND:Cigarette smoke exposure including biologically active lipopolysaccharide (LPS) in the particulate phase of cigarette smoke induces activation of alveolar macrophages (AM) and alveolar epithelial cells leading to production of inflammatory mediators. This represents a crucial mechanism in the pathogenesis of...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Droemann D,Goldmann T,Tiedje T,Zabel P,Dalhoff K,Schaaf B

    更新日期:2005-07-08 00:00:00

  • Surfactant protein D attenuates sub-epithelial fibrosis in allergic airways disease through TGF-β.

    abstract:BACKGROUND:Surfactant protein D (SP-D) can regulate both innate and adaptive immunity. Recently, SP-D has been shown to contribute to the pathogenesis of airway allergic inflammation and bleomycin-induced pulmonary fibrosis. However, in allergic airways disease, the role of SP-D in airway remodeling remains unknown. Th...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Ogawa H,Ledford JG,Mukherjee S,Aono Y,Nishioka Y,Lee JJ,Izumi K,Hollingsworth JW

    更新日期:2014-11-29 00:00:00

  • Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals.

    abstract:BACKGROUND:CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been show...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sandström CS,Novoradovskaya N,Cilio CM,Piitulainen E,Sveger T,Janciauskiene S

    更新日期:2008-04-21 00:00:00

  • Functional and phenotypical comparison of myofibroblasts derived from biopsies and bronchoalveolar lavage in mild asthma and scleroderma.

    abstract:BACKGROUND:Activated fibroblasts, which have previously been obtained from bronchoalveolar lavage fluid (BALF), are proposed to be important cells in the fibrotic processes of asthma and scleroderma (SSc). We have studied the motility for BALF derived fibroblasts in patients with SSc that may explain the presence of th...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Larsen K,Malmström J,Wildt M,Dahlqvist C,Hansson L,Marko-Varga G,Bjermer L,Scheja A,Westergren-Thorsson G

    更新日期:2006-01-23 00:00:00

  • Analysis of comorbid factors that increase the COPD assessment test scores.

    abstract:BACKGROUND:The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Miyazaki M,Nakamura H,Chubachi S,Sasaki M,Haraguchi M,Yoshida S,Tsuduki K,Shirahata T,Takahashi S,Minematsu N,Koh H,Nakamura M,Sakamaki F,Terashima T,Sayama K,Jones PW,Asano K,Betsuyaku T,Keio COPD Comorbidity Researc

    更新日期:2014-02-06 00:00:00

  • Interleukin-17 regulation: an attractive therapeutic approach for asthma.

    abstract::Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orch...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Park SJ,Lee YC

    更新日期:2010-06-16 00:00:00

  • Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a chronically progressive interstitial lung disease of unknown etiology. Previously, we have demonstrated the selective upregulation of the macrophage-derived chemokine CCL22 and the thymus activation-regulated chemokine CCL17 among chemokines, in a rat model of radiati...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Yogo Y,Fujishima S,Inoue T,Saito F,Shiomi T,Yamaguchi K,Ishizaka A

    更新日期:2009-08-29 00:00:00

  • Identification of vitamin D sensitive pathways during lung development.

    abstract:BACKGROUND:We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS:Female offspring were euthanized at different time-points; embryoni...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Chen L,Wilson R,Bennett E,Zosky GR

    更新日期:2016-04-27 00:00:00

  • Role of PM2.5 in the development and progression of COPD and its mechanisms.

    abstract:BACKGROUND:A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zhao J,Li M,Wang Z,Chen J,Zhao J,Xu Y,Wei X,Wang J,Xie J

    更新日期:2019-06-13 00:00:00

  • Signaling and regulation of G protein-coupled receptors in airway smooth muscle.

    abstract::Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that ...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Billington CK,Penn RB

    更新日期:2003-01-01 00:00:00

  • Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis.

    abstract:BACKGROUND:Functional deterioration in cystic fibrosis (CF) may be reflected by increasing bronchial obstruction and, as recently shown, by ventilation inhomogeneities. This study investigated which physiological factors (airway obstruction, ventilation inhomogeneities, pulmonary hyperinflation, development of trapped ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kraemer R,Baldwin DN,Ammann RA,Frey U,Gallati S

    更新日期:2006-11-30 00:00:00

  • Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.

    abstract:BACKGROUND:β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (Epac) was identified as another important signaling molecule of cAMP recently. The role of Epac in...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Chen YF,Huang G,Wang YM,Cheng M,Zhu FF,Zhong JN,Gao YD

    更新日期:2019-12-18 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract::Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wells AU

    更新日期:2013-01-01 00:00:00

  • Macrophage CD74 contributes to MIF-induced pulmonary inflammation.

    abstract:BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

    更新日期:2009-05-04 00:00:00

  • Primary data, claims data, and linked data in observational research: the case of COPD in Germany.

    abstract:BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

    更新日期:2018-08-30 00:00:00

  • Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.

    abstract:BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

    更新日期:2006-01-12 00:00:00

  • Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of this study was to identify FRI parameters, which predict FVC decline in patients with IPF. METH...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Clukers J,Lanclus M,Mignot B,Van Holsbeke C,Roseman J,Porter S,Gorina E,Kouchakji E,Lipson KE,De Backer W,De Backer J

    更新日期:2018-11-06 00:00:00