Role of epidermal growth factor receptor activation in regulating mucin synthesis.

Abstract:

:Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-cell metaplasia from Clara cells by a process of cell differentiation. These cells are also believed to be the cells of origin of non-small-cell lung cancer, but this occurs via cell multiplication. The mechanisms that determine which pathway is chosen are critical but largely unknown. Although no effective therapy exists for hypersecretion at present, the EGFR cascade suggests methods for effective therapeutic intervention.

journal_name

Respir Res

journal_title

Respiratory research

authors

Nadel JA

doi

10.1186/rr43

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

85-9

issue

2

eissn

1465-9921

issn

1465-993X

journal_volume

2

pub_type

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