Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D.

abstract：:Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of ...

journal_title：Respiratory research

authors： Speck NE,Schuurmans MM,Murer C,Benden C,Huber LC

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Deep inspirations (DI) have bronchodilatory and bronchoprotective effects in healthy human subjects, but these effects appear to be absent in asthmatic lungs. We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic air...

journal_title：Respiratory research

authors： Jonasson S,Swedin L,Lundqvist M,Hedenstierna G,Dahlén SE,Hjoberg J

更新日期：2008-02-28 00:00:00

abstract：:The molecular mechanisms of Idiopathic Pulmonary Fibrosis (IPF) remain elusive. Transforming Growth Factor beta 1(TGF-beta1) is a key effector cytokine in the development of lung fibrosis. We used microarray and computational biology strategies to identify genes whose expression is significantly altered in alveolar ep...

journal_title：Respiratory research

authors： Keating DT,Sadlier DM,Patricelli A,Smith SM,Walls D,Egan JJ,Doran PP

更新日期：2006-09-01 00:00:00

abstract：:The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of select neuropeptides...

journal_title：Respiratory research

authors： Atanasova KR,Reznikov LR

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Cigarette smoke is a major risk factor for chronic obstructive pulmonary disease (COPD), an inflammatory lung disorder. COPD is characterized by an increase in CD8(+) T cells within the central and peripheral airways. We hypothesized that the CD8(+) T cells in COPD patients have increased Toll-like receptor ...

journal_title：Respiratory research

authors： Nadigel J,Préfontaine D,Baglole CJ,Maltais F,Bourbeau J,Eidelman DH,Hamid Q

更新日期：2011-11-09 00:00:00

abstract：BACKGROUND:Idiopathic and toxic pulmonary fibrosis are severe diseases starting classically in the subpleural area of the lung. It has recently been suggested that pleural mesothelial cells acquire a myofibroblast phenotype under fibrotic conditions induced by TGF-β1 or bleomycin. The importance and role of inflammatio...

journal_title：Respiratory research

authors： Burgy O,Bellaye PS,Causse S,Beltramo G,Wettstein G,Boutanquoi PM,Goirand F,Garrido C,Bonniaud P

更新日期：2016-11-29 00:00:00

abstract：BACKGROUND:Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. METHODS:We selected 31 phenotypic variables and 12 ...

journal_title：Respiratory research

authors： Cho MH,Washko GR,Hoffmann TJ,Criner GJ,Hoffman EA,Martinez FJ,Laird N,Reilly JJ,Silverman EK

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV1) preceding the first reported symptom and after the start of an exacer...

journal_title：Respiratory research

authors： Watz H,Tetzlaff K,Magnussen H,Mueller A,Rodriguez-Roisin R,Wouters EFM,Vogelmeier C,Calverley PMA

更新日期：2018-12-13 00:00:00

abstract：BACKGROUND:The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect of early anti-PCP treatment on clinical outcomes in HIV-negative patient with severe PCP. Theref...

journal_title：Respiratory research

authors： Ko RE,Na SJ,Huh K,Suh GY,Jeon K

更新日期：2019-09-26 00:00:00

abstract：BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...

journal_title：Respiratory research

authors： Milara J,Díaz-Platas L,Contreras S,Ribera P,Roger I,Ballester B,Montero P,Cogolludo Á,Morcillo E,Cortijo J

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS...

journal_title：Respiratory research

authors： Xie S,Issa R,Sukkar MB,Oltmanns U,Bhavsar PK,Papi A,Caramori G,Adcock I,Chung KF

更新日期：2005-12-16 00:00:00

abstract：BACKGROUND:Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveol...

journal_title：Respiratory research

authors： Nihlberg K,Larsen K,Hultgårdh-Nilsson A,Malmström A,Bjermer L,Westergren-Thorsson G

更新日期：2006-03-29 00:00:00

abstract：BACKGROUND:Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in insomnia sufferers. Thus, the aim of this study was to examine the pr...

journal_title：Respiratory research

authors： Hein M,Lanquart JP,Loas G,Hubain P,Linkowski P

更新日期：2017-07-06 00:00:00

abstract：BACKGROUND:Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophi...

journal_title：Respiratory research

authors： Kolsum U,Donaldson GC,Singh R,Barker BL,Gupta V,George L,Webb AJ,Thurston S,Brookes AJ,McHugh TD,Wedzicha JA,Brightling CE,Singh D

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

journal_title：Respiratory research

authors： Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:The study of small airway diseases such as post-transplant bronchiolitis obliterans syndrome (BOS) is hampered by the difficulty in assessing peripheral airway function either physiologically or directly. Our aims were to develop robust methods for sampling small airway epithelial cells (SAEC) and to establi...

journal_title：Respiratory research

authors： Banerjee B,Kicic A,Musk M,Sutanto EN,Stick SM,Chambers DC

更新日期：2009-10-26 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflammation and tissue remodeling. However, few studies have explored whether YKL-40 is associated with i...

journal_title：Respiratory research

authors： Liu L,Zhang X,Liu Y,Zhang L,Zheng J,Wang J,Hansbro PM,Wang L,Wang G,Hsu AC

更新日期：2019-05-22 00:00:00

abstract：: ...

journal_title：Respiratory research

authors：

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:High frequency chest wall oscillation (HFCWO) is used for airway mucus clearance. The objective of this study was to evaluate the use of HFCWO early in the treatment of adults hospitalized for acute asthma or chronic obstructive pulmonary disease (COPD). METHODS:Randomized, multi-center, double-masked phase...

journal_title：Respiratory research

authors： Mahajan AK,Diette GB,Hatipoğlu U,Bilderback A,Ridge A,Harris VW,Dalapathi V,Badlani S,Lewis S,Charbeneau JT,Naureckas ET,Krishnan JA

更新日期：2011-09-10 00:00:00

abstract：BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

journal_title：Respiratory research

authors： Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

更新日期：2006-03-02 00:00:00

abstract：BACKGROUND:Acute respiratory failure (ARF) and severe sepsis (SS) are possible complications in patients with community-acquired pneumonia (CAP). The aim of the study was to evaluate prevalence, characteristics, risk factors and impact on mortality of hospitalized patients with CAP according to the presence of ARF and ...

journal_title：Respiratory research

authors： Aliberti S,Brambilla AM,Chalmers JD,Cilloniz C,Ramirez J,Bignamini A,Prina E,Polverino E,Tarsia P,Pesci A,Torres A,Blasi F,Cosentini R

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling process in wound healing and disease development. However, the involvement of bronchial epithelial ...

journal_title：Respiratory research

authors： Ishikawa S,Ishimori K,Ito S

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. METHODS:We performed a cross-sectional study comparing subjects with COPD and asthma to subjects ...

journal_title：Respiratory research

authors： Hardin M,Silverman EK,Barr RG,Hansel NN,Schroeder JD,Make BJ,Crapo JD,Hersh CP,COPDGene Investigators.

更新日期：2011-09-27 00:00:00

abstract：:Transposable elements (TEs) are a class of mobile genetic elements (MGEs) that were long regarded as junk DNA, which make up approximately 45% of the genome. Although most of these elements are rendered inactive by mutations and other gene silencing mechanisms, TEs such as long interspersed nuclear elements (LINEs) ar...

journal_title：Respiratory research

authors： Sargurupremraj M,Wjst M

更新日期：2013-10-05 00:00:00

abstract：BACKGROUND:High-tidal-volume mechanical ventilation and hyperoxia used in patients with acute lung injury (ALI) can induce the release of cytokines, including high-mobility group box-1 (HMGB1), oxygen radicals, neutrophil infiltration, and the disruption of epithelial and endothelial barriers. Hyperoxia has been shown ...

journal_title：Respiratory research

authors： Li LF,Yang CT,Huang CC,Liu YY,Kao KC,Lin HC

更新日期：2011-07-05 00:00:00

abstract：BACKGROUND:The human small airway epithelium (SAE) plays a central role in the early events in the pathogenesis of most inherited and acquired lung disorders. Little is known about the molecular phenotypes of the specific cell populations comprising the SAE in humans, and the contribution of SAE specific cell populatio...

journal_title：Respiratory research

authors： Zuo WL,Rostami MR,Shenoy SA,LeBlanc MG,Salit J,Strulovici-Barel Y,O'Beirne SL,Kaner RJ,Leopold PL,Mezey JG,Schymeinsky J,Quast K,Visvanathan S,Fine JS,Thomas MJ,Crystal RG

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover; two crucial process...

journal_title：Respiratory research

authors： Verhees KJ,Pansters NA,Baarsma HA,Remels AH,Haegens A,de Theije CC,Schols AM,Gosens R,Langen RC

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:WNT/β-catenin signaling plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the role of WNT10A via transforming growth factor (TGF)-β signaling remains unclear. METHODS:We evaluated the expression of WNT10A and TGF-β in bleomycin (BLM)-treated mice and the interactio...

journal_title：Respiratory research

authors： Oda K,Yatera K,Izumi H,Ishimoto H,Yamada S,Nakao H,Hanaka T,Ogoshi T,Noguchi S,Mukae H

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Chronic respiratory diseases (CRDs) are leading causes of morbidity worldwide. However, the spatial and temporal trends in prevalence and incidence of CRDs have not been estimated. METHODS:Based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, we analyzed the prevalence and...

journal_title：Respiratory research

authors： Xie M,Liu X,Cao X,Guo M,Li X

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00