当前位置： SCI文献检索 > RESPIRATORY RESEARCH期刊下所有文献 > Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects.

Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects.

Abstract：

BACKGROUND:Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in insomnia sufferers. Thus, the aim of this study was to examine the prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in a large sample of insomnia sufferers. METHODS:Data from 1311 insomnia sufferers who were recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. An apnea-hypopnea index of ≥15 events per hour was used as the cut-off score for moderate to severe obstructive sleep apnea syndrome. Logistic regression analyses were conducted to examine clinical and demographic risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers. RESULTS:The prevalence of moderate to severe obstructive sleep apnea syndrome in our sample of insomnia sufferers was 13.88%. Multivariate logistic regression analysis revealed that male gender, snoring, excessive daytime sleepiness, lower maintenance insomnia complaint, presence of metabolic syndrome, age ≥ 50 & <65 years, age ≥ 65 years, BMI ≥ 25 & <30 kg/m2, BMI >30 kg/m2, and CRP >7 mg/L were significant risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers. CONCLUSION:Moderate to severe obstructive sleep apnea syndrome is a common pathology in insomnia sufferers. The identification of these different risk factors advances a new perspective for more effective screening of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers.

journal_name

Respir Res

journal_title

Respiratory research

authors

Hein M,Lanquart JP,Loas G,Hubain P,Linkowski P

doi

10.1186/s12931-017-0616-8

subject

Has Abstract

pub_date

2017-07-06 00:00:00

pages

135

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-017-0616-8

journal_volume

18

pub_type

杂志文章

相关文献

RESPIRATORY RESEARCH文献大全
  • Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.

    abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensive care units with associated high care costs. There are many potential...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0856-2

    authors： Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS

    更新日期：2018-08-22 00:00:00

  • Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma.

    abstract：BACKGROUND:Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily (BD) regimens of the novel inhaled corticosteroid fluticasone furoate (FF) in ast...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/1465-9921-12-160

    authors： Woodcock A,Bleecker ER,Busse WW,Lötvall J,Snowise NG,Frith L,Jacques L,Haumann B,Bateman ED

    更新日期：2011-12-21 00:00:00

  • Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) significantly reduced the rate ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-014-0157-3

    authors： Hostettler KE,Zhong J,Papakonstantinou E,Karakiulakis G,Tamm M,Seidel P,Sun Q,Mandal J,Lardinois D,Lambers C,Roth M

    更新日期：2014-12-12 00:00:00

  • COPD diagnosis related to different guidelines and spirometry techniques.

    abstract：:The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-8-89

    authors： Nathell L,Nathell M,Malmberg P,Larsson K

    更新日期：2007-12-04 00:00:00

  • Factors affecting exhaled nitric oxide measurements: the effect of sex.

    abstract：BACKGROUND:Exhaled nitric oxide (F(E)NO) measurements are used as a surrogate marker for eosinophilic airway inflammation. However, many constitutional and environmental factors affect F(E)NO, making it difficult to devise reference values. Our aim was to evaluate the relative importance of factors affecting F(E)NO in ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-8-82

    authors： Taylor DR,Mandhane P,Greene JM,Hancox RJ,Filsell S,McLachlan CR,Williamson AJ,Cowan JO,Smith AD,Sears MR

    更新日期：2007-11-15 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract：:Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-14-S1-S2

    authors： Wells AU

    更新日期：2013-01-01 00:00:00

  • Oxygen-regulated transcription factors and their role in pulmonary disease.

    abstract：:The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, whic...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/rr27

    authors： Semenza GL

    更新日期：2000-01-01 00:00:00

  • Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis.

    abstract：BACKGROUND:Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, h...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0798-8

    authors： Heukels P,van Hulst JAC,van Nimwegen M,Boorsma CE,Melgert BN,van den Toorn LM,Boomars KAT,Wijsenbeek MS,Hoogsteden H,von der Thüsen JH,Hendriks RW,Kool M,van den Blink B

    更新日期：2018-05-10 00:00:00

  • Low-molecular-weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinase-protein kinase B.

    abstract：BACKGROUND:High-tidal-volume mechanical ventilation and hyperoxia used in patients with acute lung injury (ALI) can induce the release of cytokines, including high-mobility group box-1 (HMGB1), oxygen radicals, neutrophil infiltration, and the disruption of epithelial and endothelial barriers. Hyperoxia has been shown ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-90

    authors： Li LF,Yang CT,Huang CC,Liu YY,Kao KC,Lin HC

    更新日期：2011-07-05 00:00:00

  • Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats.

    abstract：BACKGROUND:Advanced glycation end products (AGEs) have been proposed to be involved in pulmonary fibrosis, but its role in this process has not been fully understood. To investigate the role of AGE formation in pulmonary fibrosis, we used a bleomycin (BLM)-stimulated rat model treated with aminoguanidine (AG), a crossl...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-10-55

    authors： Chen L,Wang T,Wang X,Sun BB,Li JQ,Liu DS,Zhang SF,Liu L,Xu D,Chen YJ,Wen FQ

    更新日期：2009-06-24 00:00:00

  • Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.

    abstract：BACKGROUND:Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea. METHODS:Data from 1828 patients with moderate to ...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1465-9921-11-29

    authors： Giardino ND,Curtis JL,Andrei AC,Fan VS,Benditt JO,Lyubkin M,Naunheim K,Criner G,Make B,Wise RA,Murray SK,Fishman AP,Sciurba FC,Liberzon I,Martinez FJ,NETT Research Group.

    更新日期：2010-03-09 00:00:00

  • Matrix metalloproteinases in lung biology.

    abstract：:Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and r...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/rr33

    authors： Parks WC,Shapiro SD

    更新日期：2001-01-01 00:00:00

  • VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway.

    abstract：BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-37

    authors： Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

    更新日期：2006-03-02 00:00:00

  • Responses of FEV6, FVC, and FET to inhaled bronchodilator in the adult general population.

    abstract：BACKGROUND:The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds (FEV6), and FET in the bronchodilation ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-10-71

    authors： Kainu A,Lindqvist A,Sarna S,Lundbäck B,Sovijärvi A

    更新日期：2009-07-28 00:00:00

  • Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.

    abstract：BACKGROUND:Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-018-0727-x

    authors： Li L,Ren F,Qi C,Xu L,Fang Y,Liang M,Feng J,Chen B,Ning W,Cao J

    更新日期：2018-02-12 00:00:00

  • Endotoxin receptor CD14 in PiZ alpha-1-antitrypsin deficiency individuals.

    abstract：BACKGROUND:CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been show...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-34

    authors： Sandström CS,Novoradovskaya N,Cilio CM,Piitulainen E,Sveger T,Janciauskiene S

    更新日期：2008-04-21 00:00:00

  • Monitoring mandibular movements to detect Cheyne-Stokes Breathing.

    abstract：BACKGROUND:The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with "sharp" large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by periodic abnormal MM p...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-017-0551-8

    authors： Martinot JB,Borel JC,Le-Dong NN,Guénard HJ,Cuthbert V,Silkoff PE,Gozal D,Pepin JL

    更新日期：2017-04-20 00:00:00

  • BMI is associated with FEV1 decline in chronic obstructive pulmonary disease: a meta-analysis of clinical trials.

    abstract：BACKGROUND:There is considerable heterogeneity in the rate of lung function decline in chronic obstructive pulmonary disease (COPD), the determinants of which are largely unknown. Observational studies in COPD indicate that low body mass index (BMI) is associated with worse outcomes, and overweight/obesity has a protec...

    journal_title：Respiratory research

    pub_type： 杂志文章,meta分析

    doi：10.1186/s12931-019-1209-5

    authors： Sun Y,Milne S,Jaw JE,Yang CX,Xu F,Li X,Obeidat M,Sin DD

    更新日期：2019-10-29 00:00:00

  • The impact of low-frequency, low-force cyclic stretching of human bronchi on airway responsiveness.

    abstract：BACKGROUND:In vivo, the airways are constantly subjected to oscillatory strain (due to tidal breathing during spontaneous respiration) and (in the event of mechanical ventilation) positive pressure. This exposure is especially problematic for the cartilage-free bronchial tree. The effects of cyclic stretching (other th...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-016-0464-y

    authors： Le Guen M,Grassin-Delyle S,Naline E,Buenestado A,Brollo M,Longchampt E,Kleinmann P,Devillier P,Faisy C

    更新日期：2016-11-14 00:00:00

  • Blood and sputum eosinophils in COPD; relationship with bacterial load.

    abstract：BACKGROUND:Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophi...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-017-0570-5

    authors： Kolsum U,Donaldson GC,Singh R,Barker BL,Gupta V,George L,Webb AJ,Thurston S,Brookes AJ,McHugh TD,Wedzicha JA,Brightling CE,Singh D

    更新日期：2017-05-08 00:00:00

  • The efficacy of mesenchymal stromal cell-derived therapies for acute respiratory distress syndrome-a meta-analysis of preclinical trials.

    abstract：BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01574-y

    authors： Wang F,Fang B,Qiang X,Shao J,Zhou L

    更新日期：2020-11-20 00:00:00

  • Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review.

    abstract：:Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medline/PubMed to ident...

    journal_title：Respiratory research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1186/1465-9921-5-17

    authors： Kankaanranta H,Lahdensuo A,Moilanen E,Barnes PJ

    更新日期：2004-10-27 00:00:00

  • IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

    abstract：BACKGROUND:Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. METHODS:In the Isle of Wight birth cohort ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-2

    authors： Sadeghnejad A,Karmaus W,Arshad SH,Kurukulaaratchy R,Huebner M,Ewart S

    更新日期：2008-01-10 00:00:00

  • Chronic exposure of diesel exhaust particles induces alveolar enlargement in mice.

    abstract：BACKGROUND:Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and mechanisms of respiratory tract injuries caused by chronic exposure to air pollution remain to be clar...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-015-0172-z

    authors： Yoshizaki K,Brito JM,Moriya HT,Toledo AC,Ferzilan S,Ligeiro de Oliveira AP,Machado ID,Farsky SH,Silva LF,Martins MA,Saldiva PH,Mauad T,Macchione M

    更新日期：2015-02-07 00:00:00

  • Association of time-to-treatment with outcomes of Pneumocystis pneumonia with respiratory failure in HIV-negative patients.

    abstract：BACKGROUND:The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect of early anti-PCP treatment on clinical outcomes in HIV-negative patient with severe PCP. Theref...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1188-6

    authors： Ko RE,Na SJ,Huh K,Suh GY,Jeon K

    更新日期：2019-09-26 00:00:00

  • Predictive factors of severe coronavirus disease 2019 in previously healthy young adults: a single-center, retrospective study.

    abstract：BACKGROUND:Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined. METHOD:We retrospectively analyzed 123 previously healthy young adults diagnosed with COVID-19 from January to March 2020...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01412-1

    authors： Zhou C,Huang Z,Tan W,Li X,Yin W,Xiao Y,Tao Z,Geng S,Hu Y

    更新日期：2020-06-22 00:00:00

  • Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline.

    abstract：BACKGROUND:To identify COPD associated gene susceptibility and lung function in a longitudinal cohort including COPD and subjects who were at risk for developing COPD, and to replicate this in two cross-sectional and longitudinal populations in Chinese Han population. METHODS:Three cohorts were recruited in this study...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s12931-015-0209-3

    authors： Xie J,Wu H,Xu Y,Wu X,Liu X,Shang J,Zhao J,Zhao J,Wang J,Dela Cruz CS,Xiong W,Xu Y

    更新日期：2015-04-18 00:00:00

  • IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.

    abstract：:The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activity of the epithelium. However, the presence of Th2 cytok...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-59

    authors： Zuyderduyn S,Ninaber DK,Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Prins FA,van Wetering S,Rabe KF,Hiemstra PS

    更新日期：2011-05-02 00:00:00

  • Role of epidermal growth factor receptor activation in regulating mucin synthesis.

    abstract：:Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-ce...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/rr43

    authors： Nadel JA

    更新日期：2001-01-01 00:00:00

  • Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis.

    abstract：:Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several k...

    journal_title：Respiratory research

    pub_type： 社论

    doi：10.1186/1465-9921-15-41

    authors： Qvist T,Pressler T,Høiby N,Katzenstein TL

    更新日期：2014-04-11 00:00:00