Abstracts from the 2018 Respiratory Effectiveness Group Summit : Amsterdam, the Netherlands. 22-24 March 2018.

Abstract:

:

journal_name

Respir Res

journal_title

Respiratory research

authors

doi

10.1186/s12931-018-0930-9

subject

pub_date

2018-12-20 00:00:00

pages

252

issue

Suppl 1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-018-0930-9

journal_volume

19

pub_type

  • Decline in air pollution and change in prevalence in respiratory symptoms and chronic obstructive pulmonary disease in elderly women.

    abstract:BACKGROUND:While adverse effects of exposure to air pollutants on respiratory health are well studied, little is known about the effect of a reduction in air pollutants on chronic respiratory symptoms and diseases. We investigated whether different declines in air pollution levels in industrialised and rural areas in G...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-11-113

    authors: Schikowski T,Ranft U,Sugiri D,Vierkötter A,Brüning T,Harth V,Krämer U

    更新日期:2010-08-22 00:00:00

  • Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema.

    abstract:BACKGROUND:It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity. Because systemic inflammation is also a component of emphysema, we hypothesize that peripheral CD8+ T lymphocyt...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-8-62

    authors: Morissette MC,Parent J,Milot J

    更新日期:2007-09-06 00:00:00

  • A comparison of four different models of acute respiratory distress syndrome in sheep.

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01475-0

    authors: Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

    更新日期:2020-08-08 00:00:00

  • Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes.

    abstract:BACKGROUND:Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-014-0161-7

    authors: Hodge G,Jersmann H,Tran HB,Holmes M,Reynolds PN,Hodge S

    更新日期:2015-01-09 00:00:00

  • Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression.

    abstract:BACKGROUND:Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD or if RelB prevents C...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-015-0214-6

    authors: Sheridan JA,Zago M,Nair P,Li PZ,Bourbeau J,Tan WC,Hamid Q,Eidelman DH,Benedetti AL,Baglole CJ

    更新日期:2015-05-06 00:00:00

  • A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium.

    abstract:BACKGROUND:Pulmonary neuroendocrine cells (PNEC) are specialized epithelial cells that are thought to play important roles in lung development and airway function. PNEC occur either singly or in clusters called neuroepithelial bodies. Our aim was to characterize the three dimensional morphology of PNEC, their distribut...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-6-115

    authors: Weichselbaum M,Sparrow MP,Hamilton EJ,Thompson PJ,Knight DA

    更新日期:2005-10-10 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract::Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-14-S1-S2

    authors: Wells AU

    更新日期:2013-01-01 00:00:00

  • Indacaterol/glycopyrronium is cost-effective compared to salmeterol/fluticasone in COPD: FLAME-based modelling in a Swedish population.

    abstract:BACKGROUND:This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS:A previously published and valida...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/s12931-017-0688-5

    authors: Bjermer L,van Boven JFM,Costa-Scharplatz M,Keininger DL,Gutzwiller FS,Lisspers K,Mahon R,Olsson P,Roche N

    更新日期:2017-12-11 00:00:00

  • Neurotrophins and neurotrophin receptors in pulmonary sarcoidosis - granulomas as a source of expression.

    abstract:BACKGROUND:Pulmonary sarcoidosis is an inflammatory disease, characterized by an accumulation of CD4+ lymphocytes and the formation of non-caseating epithelioid cell granulomas in the lungs. The disease either resolves spontaneously or develops into a chronic disease with fibrosis. The neurotrophins nerve growth factor...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-11-156

    authors: Dagnell C,Grunewald J,Kramar M,Haugom-Olsen H,Elmberger GP,Eklund A,Olgart Höglund C

    更新日期:2010-11-08 00:00:00

  • PDGF-Ralpha gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts.

    abstract:BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-10-119

    authors: Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

    更新日期:2009-11-25 00:00:00

  • Abnormal pulmonary function tests predict the development of radiation-induced pneumonitis in advanced non-small cell lung Cancer.

    abstract:BACKGROUND:Radiation pneumonitis (RP) is a frequent complication of concurrent chemoradiotherapy (CCRT) and is associated with severe symptoms that decrease quality of life and might result in pulmonary fibrosis or death. The aim of this study is to identify whether pulmonary function test (PFT) abnormalities may predi...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12931-018-0775-2

    authors: Torre-Bouscoulet L,Muñoz-Montaño WR,Martínez-Briseño D,Lozano-Ruiz FJ,Fernández-Plata R,Beck-Magaña JA,García-Sancho C,Guzmán-Barragán A,Vergara E,Blake-Cerda M,Gochicoa-Rangel L,Maldonado F,Arroyo-Hernández M,Arrieta O

    更新日期:2018-04-24 00:00:00

  • Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma.

    abstract:BACKGROUND:Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lun...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1465-9921-6-52

    authors: Litonjua AA,Tantisira KG,Lake S,Lazarus R,Richter BG,Gabriel S,Silverman ES,Weiss ST

    更新日期:2005-06-03 00:00:00

  • LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms.

    abstract:BACKGROUND:IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, remains however unknown. METHODS:The present study investigated the role of intracellular signalling a...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-8-71

    authors: Chanteux H,Guisset AC,Pilette C,Sibille Y

    更新日期:2007-10-04 00:00:00

  • Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension.

    abstract:BACKGROUND:The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling pathways (endothelin, nitric oxide, vasoactive intestine peptide (VIP) and prostacyclin) involved in the control of the pulmonary vascular and bronchial t...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-12-58

    authors: Habre W,Albu G,Janosi TZ,Fontao F,von Ungern-Sternberg BS,Beghetti M,Petak F

    更新日期:2011-04-27 00:00:00

  • The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.

    abstract:BACKGROUND:Genetic variation may underlie phenotypic variation in chronic obstructive pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). Genotype specific sub-phenotypes are likely and may underlie the poor replication of previous genetic studies. This study investigated subjec...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-9-52

    authors: Wood AM,Simmonds MJ,Bayley DL,Newby PR,Gough SC,Stockley RA

    更新日期:2008-07-11 00:00:00

  • Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.

    abstract:BACKGROUND:The identification of smoking-related lung disease in current and former smokers with normal FEV1 is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of ai...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12931-018-0911-z

    authors: Pirozzi CS,Gu T,Quibrera PM,Carretta EE,Han MK,Murray S,Cooper CB,Tashkin DP,Kleerup EC,Barjaktarevic I,Hoffman EA,Martinez CH,Christenson SA,Hansel NN,Graham Barr R,Bleecker ER,Ortega VE,Martinez FJ,Kanner RE,Paine

    更新日期:2018-11-20 00:00:00

  • Isolation and characterization of extracellular vesicles from Broncho-alveolar lavage fluid: a review and comparison of different methods.

    abstract::Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on their size, surface marker, and method of release from the host cell. Recently, EVs have become of interest i...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-019-1210-z

    authors: Carnino JM,Lee H,Jin Y

    更新日期:2019-10-30 00:00:00

  • The efficacy of mesenchymal stromal cell-derived therapies for acute respiratory distress syndrome-a meta-analysis of preclinical trials.

    abstract:BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01574-y

    authors: Wang F,Fang B,Qiang X,Shao J,Zhou L

    更新日期:2020-11-20 00:00:00

  • VEGF is upregulated by hypoxia-induced mitogenic factor via the PI-3K/Akt-NF-kappaB signaling pathway.

    abstract:BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-7-37

    authors: Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

    更新日期:2006-03-02 00:00:00

  • Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study.

    abstract:BACKGROUND:Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. M...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1465-9921-14-55

    authors: Mohamed Hoesein FA,Zanen P,de Jong PA,van Ginneken B,Boezen HM,Groen HJ,Oudkerk M,de Koning HJ,Postma DS,Lammers JW

    更新日期:2013-05-20 00:00:00

  • Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.

    abstract:BACKGROUND:Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-018-0727-x

    authors: Li L,Ren F,Qi C,Xu L,Fang Y,Liang M,Feng J,Chen B,Ning W,Cao J

    更新日期:2018-02-12 00:00:00

  • Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies.

    abstract:BACKGROUND:Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popula...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-017-0611-0

    authors: Dinh PC,Cores J,Hensley MT,Vandergriff AC,Tang J,Allen TA,Caranasos TG,Adler KB,Lobo LJ,Cheng K

    更新日期:2017-06-30 00:00:00

  • Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.

    abstract:BACKGROUND:Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea. METHODS:Data from 1828 patients with moderate to ...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1465-9921-11-29

    authors: Giardino ND,Curtis JL,Andrei AC,Fan VS,Benditt JO,Lyubkin M,Naunheim K,Criner G,Make B,Wise RA,Murray SK,Fishman AP,Sciurba FC,Liberzon I,Martinez FJ,NETT Research Group.

    更新日期:2010-03-09 00:00:00

  • Profibrotic potential of prominin-1+ epithelial progenitor cells in pulmonary fibrosis.

    abstract:BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-12-126

    authors: Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

    更新日期:2011-09-26 00:00:00

  • Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression.

    abstract:BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-019-1163-2

    authors: Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

    更新日期:2019-08-16 00:00:00

  • Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:WNT/β-catenin signaling plays an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF); however, the role of WNT10A via transforming growth factor (TGF)-β signaling remains unclear. METHODS:We evaluated the expression of WNT10A and TGF-β in bleomycin (BLM)-treated mice and the interactio...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-016-0357-0

    authors: Oda K,Yatera K,Izumi H,Ishimoto H,Yamada S,Nakao H,Hanaka T,Ogoshi T,Noguchi S,Mukae H

    更新日期:2016-04-12 00:00:00

  • Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis.

    abstract::The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of select neuropeptides...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-018-0846-4

    authors: Atanasova KR,Reznikov LR

    更新日期:2018-08-06 00:00:00

  • Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.

    abstract:BACKGROUND:Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. METHODS:The life status of a cohort of 6031 ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章

    doi:10.1186/1465-9921-6-95

    authors: de Marco R,Locatelli F,Cazzoletti L,Bugianio M,Carosso A,Marinoni A

    更新日期:2005-08-16 00:00:00

  • Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether circulating caspase-cleaved cytokeratin-18 (c...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-13-105

    authors: Cha SI,Ryerson CJ,Lee JS,Kukreja J,Barry SS,Jones KD,Elicker BM,Kim DS,Papa FR,Collard HR,Wolters PJ

    更新日期:2012-11-20 00:00:00

  • Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer.

    abstract:BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-014-0149-3

    authors: Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

    更新日期:2014-11-25 00:00:00