Cell-specific expression of lung disease risk-related genes in the human small airway epithelium.

abstract：BACKGROUND:We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS:Female offspring were euthanized at different time-points; embryoni...

journal_title：Respiratory research

authors： Chen L,Wilson R,Bennett E,Zosky GR

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with "sharp" large-amplitude MM (SPM). We hypothesized that Cheyne Stokes breathing (CSB) may be identified by periodic abnormal MM p...

journal_title：Respiratory research

authors： Martinot JB,Borel JC,Le-Dong NN,Guénard HJ,Cuthbert V,Silkoff PE,Gozal D,Pepin JL

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:Manual auscultation to detect abnormal breath sounds has poor inter-observer reliability. Digital stethoscopes with artificial intelligence (AI) could improve reliable detection of these sounds. We aimed to independently test the abilities of AI developed for this purpose. METHODS:One hundred and ninety two...

journal_title：Respiratory research

authors： Kevat A,Kalirajah A,Roseby R

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 ...

journal_title：Respiratory research

authors： Turzo M,Vaith J,Lasitschka F,Weigand MA,Busch CJ

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:The home is the predominant environment for exposure to many environmental irritants such as air pollutants and allergens. Exposure to common indoor irritants including volatile organic compounds, formaldehyde and nitrogen dioxide, may increase the risk of snoring for children. The aim of this study was to i...

journal_title：Respiratory research

authors： Zhang G,Spickett J,Rumchev K,Lee AH,Stick S

更新日期：2004-11-04 00:00:00

abstract：:The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The pas...

journal_title：Respiratory research

authors： Tzouvelekis A,Kouliatsis G,Anevlavis S,Bouros D

更新日期：2005-07-21 00:00:00

abstract：BACKGROUND:While adverse effects of exposure to air pollutants on respiratory health are well studied, little is known about the effect of a reduction in air pollutants on chronic respiratory symptoms and diseases. We investigated whether different declines in air pollution levels in industrialised and rural areas in G...

journal_title：Respiratory research

authors： Schikowski T,Ranft U,Sugiri D,Vierkötter A,Brüning T,Harth V,Krämer U

更新日期：2010-08-22 00:00:00

abstract：BACKGROUND:Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. M...

journal_title：Respiratory research

authors： Mohamed Hoesein FA,Zanen P,de Jong PA,van Ginneken B,Boezen HM,Groen HJ,Oudkerk M,de Koning HJ,Postma DS,Lammers JW

更新日期：2013-05-20 00:00:00

abstract：OBJECTIVE:We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). METHODS:A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and dist...

journal_title：Respiratory research

authors： Mao S,Wu L,Shi W

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Recent trials demonstrate increased pneumonia risk in chronic obstructive pulmonary disease patients treated with the inhaled corticosteroid (ICS) fluticasone propionate (FP). There is limited work describing FP effects on host defenses against bacterial pneumonia. METHODS:C57BL/6 mice received daily, nose-...

journal_title：Respiratory research

authors： Patterson CM,Morrison RL,D'Souza A,Teng XS,Happel KI

更新日期：2012-05-31 00:00:00

abstract：: ...

journal_title：Respiratory research

authors：

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. METHODS:We selected 31 phenotypic variables and 12 ...

journal_title：Respiratory research

authors： Cho MH,Washko GR,Hoffmann TJ,Criner GJ,Hoffman EA,Martinez FJ,Laird N,Reilly JJ,Silverman EK

更新日期：2010-03-16 00:00:00

abstract：BACKGROUND:Diesel exhaust particles (DEPs) are deposited into the respiratory tract and are thought to be a risk factor for the development of diseases of the respiratory system. In healthy individuals, the timing and mechanisms of respiratory tract injuries caused by chronic exposure to air pollution remain to be clar...

journal_title：Respiratory research

authors： Yoshizaki K,Brito JM,Moriya HT,Toledo AC,Ferzilan S,Ligeiro de Oliveira AP,Machado ID,Farsky SH,Silva LF,Martins MA,Saldiva PH,Mauad T,Macchione M

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:Recent meta-analyses of genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within/near 54 genes associated with lung function measures. Current understanding of the contribution of these genes to human lung development is limited. We set out to further define i) the expres...

journal_title：Respiratory research

authors： Miller S,Melén E,Merid SK,Hall IP,Sayers I

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Current therapy for relieving bronchoconstriction may be ineffective in severe asthma, particularly in the small airways. The aim of this study was to further characterise responses to the recently identified novel bronchodilators rosiglitazone (RGZ) and chloroquine (CQ) under conditions where β-adrenoceptor...

journal_title：Respiratory research

authors： Donovan C,Simoons M,Esposito J,Ni Cheong J,Fitzpatrick M,Bourke JE

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Mutations in the DNAI1 gene, encoding a component of outer dynein arms of the ciliary apparatus, are the second most important genetic cause of primary ciliary dyskinesia (PCD), the genetically heterogeneous recessive disorder with the prevalence of ~1/20,000. The estimates of the DNAI1 involvement in PCD pa...

journal_title：Respiratory research

authors： Ziętkiewicz E,Nitka B,Voelkel K,Skrzypczak U,Bukowy Z,Rutkiewicz E,Humińska K,Przystałowska H,Pogorzelski A,Witt M

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:The prevalence of pneumocystis pneumonia (PCP) and associated hypoxic respiratory failure is increasing in human immunodeficiency virus (HIV)-negative patients. However, no prior studies have evaluated the effect of early anti-PCP treatment on clinical outcomes in HIV-negative patient with severe PCP. Theref...

journal_title：Respiratory research

authors： Ko RE,Na SJ,Huh K,Suh GY,Jeon K

更新日期：2019-09-26 00:00:00

abstract：BACKGROUND:Symptoms of chronic obstructive pulmonary disease may vary throughout the day and it is important that therapeutic approaches provide 24-h symptom control. We report the results of two phase IIIb crossover studies, PT003011 and PT003012, investigating the 24-h lung function profile of GFF MDI (glycopyrrolate...

journal_title：Respiratory research

authors： Reisner C,Gottschlich G,Fakih F,Koser A,Krainson J,Delacruz L,Arora S,Feldman G,Pudi K,Siddiqui S,Orevillo C,Maes A,St Rose E,Martin U

更新日期：2017-08-18 00:00:00

abstract：BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

journal_title：Respiratory research

authors： Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

journal_title：Respiratory research

authors： Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimal...

journal_title：Respiratory research

authors： Witt S,Krauss E,Barbero MAN,Müller V,Bonniaud P,Vancheri C,Wells AU,Vasakova M,Pesci A,Klepetko W,Seeger W,Crestani B,Leidl R,Holle R,Schwarzkopf L,Guenther A

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a...

journal_title：Respiratory research

authors： Rodrigo T,Caylà JA,Casals M,García-García JM,Caminero JA,Ruiz-Manzano J,Blanquer R,Vidal R,Altet N,Calpe JL,Penas A,Working Group on Completion of Tuberculosis Treatment in Spain.

更新日期：2012-09-02 00:00:00

abstract：BACKGROUND:Colonization of the airways with potential pathogenic bacteria is observed in a number of chronic respiratory diseases, such as COPD or cystic fibrosis. Infections with respiratory viruses are known triggers of exacerbations of these diseases. We here investigated if pre-exposure to bacteria alters the respo...

journal_title：Respiratory research

authors： Bellinghausen C,Gulraiz F,Heinzmann AC,Dentener MA,Savelkoul PH,Wouters EF,Rohde GG,Stassen FR

更新日期：2016-06-03 00:00:00

abstract：BACKGROUND:Cognitive impairment has been found in chronic obstructive pulmonary disease (COPD) patients. However, the structural alteration of the brain and underlying mechanisms are poorly understood. METHODS:Thirty-seven mild-to-moderate COPD patients, forty-eight severe COPD patients, and thirty-one control subject...

journal_title：Respiratory research

authors： Li J,Fei GH

更新日期：2013-12-21 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. METHODS:PAH in rats was induced by a single subcut...

journal_title：Respiratory research

authors： Fedorowicz A,Mateuszuk Ł,Kopec G,Skórka T,Kutryb-Zając B,Zakrzewska A,Walczak M,Jakubowski A,Łomnicka M,Słomińska E,Chlopicki S

更新日期：2016-08-31 00:00:00

abstract：BACKGROUND:CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been show...

journal_title：Respiratory research

authors： Sandström CS,Novoradovskaya N,Cilio CM,Piitulainen E,Sveger T,Janciauskiene S

更新日期：2008-04-21 00:00:00

abstract：:In many model systems, cystic fibrosis (CF) phenotype airway epithelial cells in culture respond to P. aeruginosa with greater interleukin (IL)-8 and IL-6 secretion than matched controls. In order to test whether this excess inflammatory response results from the reported increased adherence of P. aeruginosa to the CF...

journal_title：Respiratory research

authors： Kube DM,Fletcher D,Davis PB

更新日期：2005-07-11 00:00:00

abstract：BACKGROUND:Neonatal mice developed neurological disease and pulmonary dysfunction after an infection with a mouse-adapted human Enterovirus 71 (EV71) strain MP4. However, the hallmark of severe human EV71 infection, pulmonary edema (PE), was not evident. METHODS:To test whether EV71-induced PE required a proinflammato...

journal_title：Respiratory research

authors： Huang SW,Lee YP,Hung YT,Lin CH,Chuang JI,Lei HY,Su IJ,Yu CK

更新日期：2011-11-06 00:00:00

abstract：BACKGROUND:Various signals are known to participate in the pathogenesis of lung fibrosis. Our aim was to determine which signal is predominantly mobilized in the early inflammatory phase and thereafter modulates the development of lung fibrosis. METHODS:Mice received a single dose of 3 mg/kg body weight of bleomycin (...

journal_title：Respiratory research

authors： Kobayashi T,Tanaka K,Fujita T,Umezawa H,Amano H,Yoshioka K,Naito Y,Hatano M,Kimura S,Tatsumi K,Kasuya Y

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (Epac) was identified as another important signaling molecule of cAMP recently. The role of Epac in...

journal_title：Respiratory research

authors： Chen YF,Huang G,Wang YM,Cheng M,Zhu FF,Zhong JN,Gao YD

更新日期：2019-12-18 00:00:00