The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.

abstract：BACKGROUND:ExoU, a Pseudomonas aeruginosa cytotoxin with phospholipase A2 activity, was shown to induce vascular hyperpermeability and thrombus formation in a murine model of pneumosepsis. In this study, we investigated the toxin ability to induce alterations in pulmonary fibrinolysis and the contribution of the platel...

journal_title：Respiratory research

authors： Machado GB,de Oliveira AV,Saliba AM,de Lima CD,Suassuna JH,Plotkowski MC

更新日期：2011-08-05 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation and impaired immune response to pathogens leading to bacteria-induced exacerbation of the disease. A defect in Th17 cytokines in response to Streptococcus pneumoniae, a bacteria associated with COPD exacerbations, has been r...

journal_title：Respiratory research

authors： Le Rouzic O,Koné B,Kluza J,Marchetti P,Hennegrave F,Olivier C,Kervoaze G,Vilain E,Mordacq C,Just N,Perez T,Bautin N,Pichavant M,Gosset P

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

journal_title：Respiratory research

authors： Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

更新日期：2006-03-10 00:00:00

abstract：BACKGROUND:Early life impairments leading to lower lung function by adulthood are considered as risk factors for chronic obstructive pulmonary disease (COPD). Recently, we compared the lung transcriptomic profile between two mouse strains with extreme total lung capacities to identify plausible pulmonary function deter...

journal_title：Respiratory research

authors： Vishweswaraiah S,George L,Purushothaman N,Ganguly K

更新日期：2018-06-06 00:00:00

abstract：BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

journal_title：Respiratory research

authors： Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined. METHOD:We retrospectively analyzed 123 previously healthy young adults diagnosed with COVID-19 from January to March 2020...

journal_title：Respiratory research

authors： Zhou C,Huang Z,Tan W,Li X,Yin W,Xiao Y,Tao Z,Geng S,Hu Y

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

journal_title：Respiratory research

authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

更新日期：2014-11-27 00:00:00

abstract：OBJECTIVE:We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). METHODS:A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and dist...

journal_title：Respiratory research

authors： Mao S,Wu L,Shi W

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD or if RelB prevents C...

journal_title：Respiratory research

authors： Sheridan JA,Zago M,Nair P,Li PZ,Bourbeau J,Tan WC,Hamid Q,Eidelman DH,Benedetti AL,Baglole CJ

更新日期：2015-05-06 00:00:00

abstract：:COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory disease rather than a pulmonary disease. The management of hospitalized patients in COVID-19 dedicated units is a...

journal_title：Respiratory research

authors： Aliberti S,Amati F,Pappalettera M,Di Pasquale M,D'Adda A,Mantero M,Gramegna A,Simonetta E,Oneta AM,Privitera E,Gori A,Bozzi G,Peyvandi F,Minoia F,Filocamo G,Abbruzzese C,Vicenzi M,Tagliabue P,Alongi S,Blasi F

更新日期：2020-10-09 00:00:00

abstract：RESEARCH QUESTION:There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment. PATIENTS A...

journal_title：Respiratory research

authors： Pastre J,Barnett S,Ksovreli I,Taylor J,Brown AW,Shlobin OA,Ahmad K,Khangoora V,Aryal S,King CS,Nathan SD

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleotide polymorphism Glu342Lys (Z-mutation). Despite the recommendation to test every COPD patient, the c...

journal_title：Respiratory research

authors： Greulich T,Rodríguez-Frias F,Belmonte I,Klemmer A,Vogelmeier CF,Miravitlles M

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...

journal_title：Respiratory research

authors： Maarsingh H,Leusink J,Bos IS,Zaagsma J,Meurs H

更新日期：2006-01-12 00:00:00

abstract：:Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host...

journal_title：Respiratory research

authors： Kesic MJ,Hernandez M,Jaspers I

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Genetic variation may underlie phenotypic variation in chronic obstructive pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). Genotype specific sub-phenotypes are likely and may underlie the poor replication of previous genetic studies. This study investigated subjec...

journal_title：Respiratory research

authors： Wood AM,Simmonds MJ,Bayley DL,Newby PR,Gough SC,Stockley RA

更新日期：2008-07-11 00:00:00

abstract：BACKGROUND:High-tidal-volume mechanical ventilation and hyperoxia used in patients with acute lung injury (ALI) can induce the release of cytokines, including high-mobility group box-1 (HMGB1), oxygen radicals, neutrophil infiltration, and the disruption of epithelial and endothelial barriers. Hyperoxia has been shown ...

journal_title：Respiratory research

authors： Li LF,Yang CT,Huang CC,Liu YY,Kao KC,Lin HC

更新日期：2011-07-05 00:00:00

abstract：BACKGROUND:The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a ...

journal_title：Respiratory research

authors： Lee SH,Park MS,Kim SY,Kim DS,Kim YW,Chung MP,Uh ST,Park CS,Park SW,Jeong SH,Park YB,Lee HL,Shin JW,Lee EJ,Lee JH,Jegal Y,Lee HK,Kim YH,Song JW,Park JS

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of life in COPD patients. Total lung capacity (TLC) is an indicator of hyperinflation particularly in ...

journal_title：Respiratory research

authors： Lee JH,McDonald ML,Cho MH,Wan ES,Castaldi PJ,Hunninghake GM,Marchetti N,Lynch DA,Crapo JD,Lomas DA,Coxson HO,Bakke PS,Silverman EK,Hersh CP,COPDGene and ECLIPSE Investigators.

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:Adherence to tuberculosis (TB) treatment is troublesome, due to long therapy duration, quick therapeutic response which allows the patient to disregard about the rest of their treatment and the lack of motivation on behalf of the patient for improved. The objective of this study was to develop and validate a...

journal_title：Respiratory research

authors： Rodrigo T,Caylà JA,Casals M,García-García JM,Caminero JA,Ruiz-Manzano J,Blanquer R,Vidal R,Altet N,Calpe JL,Penas A,Working Group on Completion of Tuberculosis Treatment in Spain.

更新日期：2012-09-02 00:00:00

abstract：BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

journal_title：Respiratory research

authors： Wang F,Fang B,Qiang X,Shao J,Zhou L

更新日期：2020-11-20 00:00:00

abstract：:The attraction of leukocytes from circulation to inflamed lungs depends on the activation of both the leukocytes and the resident cells within the lung. In this study we determined gene expression and secretion patterns for monocyte chemoattractant protein-1 (MCP-1/CCL2) and T-cell specific CXCR3 agonistic chemokines ...

journal_title：Respiratory research

authors： Pechkovsky DV,Goldmann T,Ludwig C,Prasse A,Vollmer E,Müller-Quernheim J,Zissel G

更新日期：2005-07-20 00:00:00

abstract：:Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs' surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which...

journal_title：Respiratory research

authors： Carreto-Binaghi LE,Aliouat el M,Taylor ML

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophi...

journal_title：Respiratory research

authors： Kolsum U,Donaldson GC,Singh R,Barker BL,Gupta V,George L,Webb AJ,Thurston S,Brookes AJ,McHugh TD,Wedzicha JA,Brightling CE,Singh D

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate i...

journal_title：Respiratory research

authors： Grogono JC,Butler C,Izadi H,Moosavi SH

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lun...

journal_title：Respiratory research

authors： Litonjua AA,Tantisira KG,Lake S,Lazarus R,Richter BG,Gabriel S,Silverman ES,Weiss ST

更新日期：2005-06-03 00:00:00

abstract：BACKGROUND:Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. METHODS:In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 alpha1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplant...

journal_title：Respiratory research

authors： Calabrese F,Giacometti C,Beghe B,Rea F,Loy M,Zuin R,Marulli G,Baraldo S,Saetta M,Valente M

更新日期：2005-02-10 00:00:00

abstract：BACKGROUND:Low body mass index has been associated with increased mortality in severe COPD. The impact of body composition earlier in the disease remains unclear. We studied the impact of body composition on the risk of functional limitation in COPD. METHODS:We used bioelectrical impedance to estimate body composition...

journal_title：Respiratory research

authors： Eisner MD,Blanc PD,Sidney S,Yelin EH,Lathon PV,Katz PP,Tolstykh I,Ackerson L,Iribarren C

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:Secondary pulmonary alveolar septal formation requires platelet derived growth factor (PDGF-A) and platelet derived growth factor receptor-alpha (PDGFRα), and their regulation influences alveolar septal areal density and thickness. Insufficient PDGFRα expression in lung fibroblasts (LF) results in failed sep...

journal_title：Respiratory research

authors： McGowan SE,McCoy DM

更新日期：2013-07-02 00:00:00

abstract：:Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several k...

journal_title：Respiratory research

authors： Qvist T,Pressler T,Høiby N,Katzenstein TL

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue, along with the inducible expression in response to infectious stimuli, localization, and antimicrob...

journal_title：Respiratory research

authors： Yanagi S,Ashitani J,Ishimoto H,Date Y,Mukae H,Chino N,Nakazato M

更新日期：2005-11-04 00:00:00