Prevalence and distribution patterns of allergens among children with asthma and asthma-like symptoms in Shanghai, China.

abstract：BACKGROUND:The common cold is the most widespread viral infection in humans. Iota-carrageenan has previously shown antiviral effectiveness against cold viruses in clinical trials. This study investigated the efficacy of a carrageenan-containing nasal spray on the duration of the common cold and nasal fluid viral load i...

journal_title：Respiratory research

authors： Ludwig M,Enzenhofer E,Schneider S,Rauch M,Bodenteich A,Neumann K,Prieschl-Grassauer E,Grassauer A,Lion T,Mueller CA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveol...

journal_title：Respiratory research

authors： Nihlberg K,Larsen K,Hultgårdh-Nilsson A,Malmström A,Bjermer L,Westergren-Thorsson G

更新日期：2006-03-29 00:00:00

abstract：BACKGROUND:The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and chemokines. Both the transcription factor hypoxia inducible factor-1 (HIF-1) and chemokine CCL2 have been shown to play pivotal roles in allergic airw...

journal_title：Respiratory research

authors： Baay-Guzman GJ,Bebenek IG,Zeidler M,Hernandez-Pando R,Vega MI,Garcia-Zepeda EA,Antonio-Andres G,Bonavida B,Riedl M,Kleerup E,Tashkin DP,Hankinson O,Huerta-Yepez S

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...

journal_title：Respiratory research

authors： Pfarr N,Fischer C,Ehlken N,Becker-Grünig T,López-González V,Gorenflo M,Hager A,Hinderhofer K,Miera O,Nagel C,Schranz D,Grünig E

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Gas exchange represents the key physiological function of the lung, and is dependent upon proper formation of the delicate alveolar structure. Malformation or destruction of the alveolar gas-exchange regions are key histopathological hallmarks of diseases such as bronchopulmonary dysplasia (BPD), chronic obs...

journal_title：Respiratory research

authors： Rodríguez-Castillo JA,Pérez DB,Ntokou A,Seeger W,Morty RE,Ahlbrecht K

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Although T cells, especially CD8+, have been implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, their role during acute exacerbations (AE-COPD) is uncertain. METHODS:We recruited subjects with COPD and a history of previous AE-COPD and studied them quarterly to collect blood and sponta...

journal_title：Respiratory research

authors： Freeman CM,Martinez CH,Todt JC,Martinez FJ,Han MK,Thompson DL,McCloskey L,Curtis JL

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids. METHODS:AMs obtained by fiberoptic bronch...

journal_title：Respiratory research

authors： Bhavsar PK,Levy BD,Hew MJ,Pfeffer MA,Kazani S,Israel E,Chung KF

更新日期：2010-06-07 00:00:00

abstract：BACKGROUND:Motor vehicle-related air pollution can potentially impair lung function. The effect of pollution in people with compromised pulmonary function such as in COPD has not been previously investigated. To examine the association of lung function with motor vehicle density in people with spirometrically determine...

journal_title：Respiratory research

authors： Nitschke M,Appleton SL,Li Q,Tucker GR,Shah P,Bi P,Pisaniello DL,Adams RJ

更新日期：2016-10-24 00:00:00

abstract：BACKGROUND:Smoking cessation following lung cancer diagnosis has been found to improve several patient outcomes. Electronic cigarette (e-cigarette) use is now prevalent within Great Britain, however, use and practice among patients with lung cancer has not as yet been explored. The current study aims to explore e-cigar...

journal_title：Respiratory research

authors： Sherratt FC,Newson L,Field JK

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. METHODS:The life status of a cohort of 6031 ...

journal_title：Respiratory research

authors： de Marco R,Locatelli F,Cazzoletti L,Bugianio M,Carosso A,Marinoni A

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue, along with the inducible expression in response to infectious stimuli, localization, and antimicrob...

journal_title：Respiratory research

authors： Yanagi S,Ashitani J,Ishimoto H,Date Y,Mukae H,Chino N,Nakazato M

更新日期：2005-11-04 00:00:00

abstract：:The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

journal_title：Respiratory research

authors： He P,Gelissen IC,Ammit AJ

更新日期：2020-09-25 00:00:00

abstract：:Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on their size, surface marker, and method of release from the host cell. Recently, EVs have become of interest i...

journal_title：Respiratory research

authors： Carnino JM,Lee H,Jin Y

更新日期：2019-10-30 00:00:00

abstract：BACKGROUND:Low body mass index has been associated with increased mortality in severe COPD. The impact of body composition earlier in the disease remains unclear. We studied the impact of body composition on the risk of functional limitation in COPD. METHODS:We used bioelectrical impedance to estimate body composition...

journal_title：Respiratory research

authors： Eisner MD,Blanc PD,Sidney S,Yelin EH,Lathon PV,Katz PP,Tolstykh I,Ackerson L,Iribarren C

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

journal_title：Respiratory research

authors： Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:A multitude of epidemiological studies have shown that ambient fine particulate matter 2.5 (diameter < 2.5um; PM2.5) was associated with increased morbidity and mortality of chronic obstructive pulmonary disease (COPD). However, the underlying associated mechanisms have not yet been elucidated. We conducted ...

journal_title：Respiratory research

authors： Zhao J,Li M,Wang Z,Chen J,Zhao J,Xu Y,Wei X,Wang J,Xie J

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

journal_title：Respiratory research

authors： Ren Z,Hu Y,Xu L

更新日期：2019-10-16 00:00:00

abstract：:Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medline/PubMed to ident...

journal_title：Respiratory research

authors： Kankaanranta H,Lahdensuo A,Moilanen E,Barnes PJ

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...

journal_title：Respiratory research

authors： Lauwers E,Ides K,Van Hoorenbeeck K,Verhulst S

更新日期：2020-08-17 00:00:00

abstract：BACKGROUND:The relative contributions of the cytotoxic phenotype of P. aeruginosa expressing type III secretory toxins and an immunocompromised condition lacking normal Toll-like receptor 4 (TLR4) signaling in the pathogenesis of acute lung injury and sepsis were evaluated in a mouse model for Pseudomonas aeruginosa pn...

journal_title：Respiratory research

authors： Faure K,Sawa T,Ajayi T,Fujimoto J,Moriyama K,Shime N,Wiener-Kronish JP

更新日期：2004-02-12 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investig...

journal_title：Respiratory research

authors： Shimodaira K,Okubo Y,Ochiai E,Nakayama H,Katano H,Wakayama M,Shinozaki M,Ishiwatari T,Sasai D,Tochigi N,Nemoto T,Saji T,Kamei K,Shibuya K

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable dia...

journal_title：Respiratory research

authors： Ng SS,Tam W,Chan TO,To KW,Ngai J,Chan KKP,Yip WH,Lo RL,Yiu K,Ko FW,Hui DS

更新日期：2019-02-22 00:00:00

abstract：:There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of this manuscript is to systematically review the current knowledge on exhaled VOCs with respect to their poten...

journal_title：Respiratory research

authors： van de Kant KD,van der Sande LJ,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-21 00:00:00

abstract：BACKGROUND:The home is the predominant environment for exposure to many environmental irritants such as air pollutants and allergens. Exposure to common indoor irritants including volatile organic compounds, formaldehyde and nitrogen dioxide, may increase the risk of snoring for children. The aim of this study was to i...

journal_title：Respiratory research

authors： Zhang G,Spickett J,Rumchev K,Lee AH,Stick S

更新日期：2004-11-04 00:00:00

abstract：BACKGROUND:It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity. Because systemic inflammation is also a component of emphysema, we hypothesize that peripheral CD8+ T lymphocyt...

journal_title：Respiratory research

authors： Morissette MC,Parent J,Milot J

更新日期：2007-09-06 00:00:00

abstract：BACKGROUND:Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as potential biomarkers of lung allograft rejection or dysfunction. However, BAL collection is not well stan...

journal_title：Respiratory research

authors： Levy L,Juvet SC,Boonstra K,Singer LG,Azad S,Joe B,Cypel M,Keshavjee S,Martinu T

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:A disintegrin and metalloproteinase domain-15 (ADAM15) is expressed by activated leukocytes, and fibroblasts in vitro. Whether ADAM15 expression is increased in the lungs of COPD patients is not known. METHODS:ADAM15 gene expression and/or protein levels were measured in whole lung and bronchoalveolar lavag...

journal_title：Respiratory research

authors： Wang X,Zhang D,Higham A,Wolosianka S,Gai X,Zhou L,Petersen H,Pinto-Plata V,Divo M,Silverman EK,Celli B,Singh D,Sun Y,Owen CA

更新日期：2020-07-16 00:00:00

abstract：BACKGROUND:CD14, a receptor for lipopolysaccharides (LPS), is found in both a membrane-bound form (mCD14) and a soluble form (sCD14). It is suggested that sCD14 is mainly released from blood monocytes by serine protease-mediated shedding. Because alpha1-antitrypsin (AAT), an inhibitor of serine proteases, has been show...

journal_title：Respiratory research

authors： Sandström CS,Novoradovskaya N,Cilio CM,Piitulainen E,Sveger T,Janciauskiene S

更新日期：2008-04-21 00:00:00

abstract：BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

journal_title：Respiratory research

authors： Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

更新日期：2006-03-02 00:00:00

abstract：BACKGROUND:Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) is currently treated with systemic corticosteroids despite poor efficacy and side effects. This study investigated the therapeutic effect of budesonide/formoterol, montelukast and n-acetylcysteine, which a...

journal_title：Respiratory research

authors： Kim SW,Rhee CK,Kim YJ,Lee S,Kim HJ,Lee JW

更新日期：2016-05-26 00:00:00