Abstract:
BACKGROUND:Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. METHODS:Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hemorrhagic shock and Lipopolysaccharide (LPS) lung injury model. Using this model, we analyzed the cellular kinetics of lung alveolar epithelial cells. RESULTS:The results showed that alveolar epithelium type 2 cells (AEC2s) are damage resistant during acute lung injury, they might be the main cells involved in lung injury and repair. Then we observed the relationship between the expression of HGF, c-Met following ALI in rat lung and proliferation of AEC2s. The proliferation of AEC2s was inhibited when isolated primary AEC2s were co-cultured with c-Met inhibitor SU11274. Furthermore, the numbers of AEC2s was significantly decreased when ALI rats were administrated with SU11274 in vivo. It provided further evidence that the HGF/c-Met signaling plays a vital role in ALI-induced AEC2s proliferation. CONCLUSIONS:AEC2s are damage resistant during acute lung injury and the HGF/c-Met signaling pathway is of vital importance in the proliferation of AEC2s after ALI.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Zeng L,Yang XT,Li HS,Li Y,Yang C,Gu W,Zhou YH,Du J,Wang HY,Sun JH,Wen DL,Jiang JXdoi
10.1186/s12931-016-0480-ysubject
Has Abstractpub_date
2016-12-07 00:00:00pages
164issue
1eissn
1465-9921issn
1465-993Xpii
10.1186/s12931-016-0480-yjournal_volume
17pub_type
杂志文章abstract::Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of ...
journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/s12931-016-0391-y
更新日期:2016-06-21 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-10-119
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更新日期:2006-08-02 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-019-1197-5
更新日期:2019-10-16 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-015-0265-8
更新日期:2015-09-16 00:00:00
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doi:10.1186/1465-9921-5-1
更新日期:2004-02-12 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/rr17
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Although protective mechanical ventilation (MV) has been used in a variety of applications, lung injury may occur in both patients with and without acute respiratory distress syndrome (ARDS). The purpose of this study is to use machine learning to identify clinical phenotypes for critically ill patients with...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-020-01588-6
更新日期:2020-12-10 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-016-0464-y
更新日期:2016-11-14 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-12-4
更新日期:2011-01-07 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-7-38
更新日期:2006-03-10 00:00:00
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更新日期:2018-09-03 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-14-103
更新日期:2013-10-09 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-10-63
更新日期:2009-07-06 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-12-43
更新日期:2011-04-10 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-019-1188-6
更新日期:2019-09-26 00:00:00
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journal_title:Respiratory research
pub_type: 社论
doi:10.1186/1465-9921-15-41
更新日期:2014-04-11 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/s12931-020-01484-z
更新日期:2020-08-17 00:00:00
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doi:10.1186/s12931-020-01350-y
更新日期:2020-04-15 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-8-90
更新日期:2007-12-04 00:00:00
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doi:10.1186/1465-9921-7-11
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-09-27 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-020-1291-8
更新日期:2020-02-11 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1186/s12931-019-1180-1
更新日期:2019-09-12 00:00:00
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doi:10.1186/s12931-017-0645-3
更新日期:2017-08-29 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-11-113
更新日期:2010-08-22 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-11-136
更新日期:2010-10-05 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-14-3
更新日期:2013-01-09 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,随机对照试验
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更新日期:2019-02-22 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-020-01446-5
更新日期:2020-07-16 00:00:00