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Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.

Abstract：

BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable diagnostic system (Embletta PDS) at home. METHODS:Patients with suspected OSAS were recruited from respiratory clinics to complete Berlin questionnaire and Epworth Sleepiness Score (ESS). Patients were randomized to undergo either home-based sleep test (group A) or hospital-based polysomnography (PSG) (group B). RESULTS:Three hundreds and sixteen subjects with newly referred suspected OSAS were recruited and randomized into group A (n = 157) and group B (n = 159). The prevalence of moderate to severe OSAS defined as apnea-hypopnea index (AHI) ≥ 15/h was 54%. The Berlin questionnaire identified 69.7% (n = 99) of subjects as high risk in group A and 77.5% (n = 100) in group B. The sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the questionnaire to predict an AHI ≥ 15/h as diagnosed by PSG was 78, 23, 67 and 35%. When compared with Embletta PDS, the specificity and NPV increased to 48 and 63%. The area under the Receiver Operator Curve (ROC) based on PSG (AUC = 0.539, 95%CI 0.417, 0.661) and based on home Embletta (AUC = 0.712, 95%CI 0.617, 0.907). CONCLUSIONS:The questionnaire was not reliable in predicting OSAS through PSG AHI whereas there was some predictive ability in discriminating patients with OSAS from normal subjects based on home Embletta sleep test. TRIAL REGISTRATION:The study was registered at ClinicalTrials.gov (Identifier: NCT01828216) on 10 April 2013.

journal_name

Respir Res

journal_title

Respiratory research

authors

Ng SS,Tam W,Chan TO,To KW,Ngai J,Chan KKP,Yip WH,Lo RL,Yiu K,Ko FW,Hui DS

doi

10.1186/s12931-019-1009-y

subject

Has Abstract

pub_date

2019-02-22 00:00:00

pages

issue

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-019-1009-y

journal_volume

pub_type

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Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.