What have transgenic and knockout animals taught us about respiratory disease?

abstract：:Transposable elements (TEs) are a class of mobile genetic elements (MGEs) that were long regarded as junk DNA, which make up approximately 45% of the genome. Although most of these elements are rendered inactive by mutations and other gene silencing mechanisms, TEs such as long interspersed nuclear elements (LINEs) ar...

journal_title：Respiratory research

authors： Sargurupremraj M,Wjst M

更新日期：2013-10-05 00:00:00

abstract：:Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pul...

journal_title：Respiratory research

authors： Chai AB,Ammit AJ,Gelissen IC

更新日期：2017-02-28 00:00:00

abstract：:Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-ce...

journal_title：Respiratory research

authors： Nadel JA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

journal_title：Respiratory research

authors： Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

更新日期：2009-05-04 00:00:00

abstract：BACKGROUND:Smoking cessation following lung cancer diagnosis has been found to improve several patient outcomes. Electronic cigarette (e-cigarette) use is now prevalent within Great Britain, however, use and practice among patients with lung cancer has not as yet been explored. The current study aims to explore e-cigar...

journal_title：Respiratory research

authors： Sherratt FC,Newson L,Field JK

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. This study aimed to assess alveolar epithelial biomarkers as predictors for the efficacy of the anti...

journal_title：Respiratory research

authors： Ikeda K,Chiba H,Nishikiori H,Azuma A,Kondoh Y,Ogura T,Taguchi Y,Ebina M,Sakaguchi H,Miyazawa S,Suga M,Sugiyama Y,Nukiwa T,Kudoh S,Takahashi H,Pirfenidone Clinical Study Group in Japan.

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Motor vehicle-related air pollution can potentially impair lung function. The effect of pollution in people with compromised pulmonary function such as in COPD has not been previously investigated. To examine the association of lung function with motor vehicle density in people with spirometrically determine...

journal_title：Respiratory research

authors： Nitschke M,Appleton SL,Li Q,Tucker GR,Shah P,Bi P,Pisaniello DL,Adams RJ

更新日期：2016-10-24 00:00:00

abstract：BACKGROUND:Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile ...

journal_title：Respiratory research

authors： Lamarche D,Johnstone J,Zytaruk N,Clarke F,Hand L,Loukov D,Szamosi JC,Rossi L,Schenck LP,Verschoor CP,McDonald E,Meade MO,Marshall JC,Bowdish DME,Karachi T,Heels-Ansdell D,Cook DJ,Surette MG,PROSPECT Investigators.,C

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV1) preceding the first reported symptom and after the start of an exacer...

journal_title：Respiratory research

authors： Watz H,Tetzlaff K,Magnussen H,Mueller A,Rodriguez-Roisin R,Wouters EFM,Vogelmeier C,Calverley PMA

更新日期：2018-12-13 00:00:00

abstract：BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

journal_title：Respiratory research

authors： Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

更新日期：2014-11-25 00:00:00

abstract：: ...

journal_title：Respiratory research

authors： Lotvall J,Panettieri RA Jr

更新日期：2018-11-26 00:00:00

abstract：BACKGROUND:Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships. METHODS:Children underwent home collections of nasal lavage during scheduled surveillance periods and...

journal_title：Respiratory research

authors： Lewis TC,Metitiri EE,Mentz GB,Ren X,Carpenter AR,Goldsmith AM,Wicklund KE,Eder BN,Comstock AT,Ricci JM,Brennan SR,Washington GL,Owens KB,Mukherjee B,Robins TG,Batterman SA,Hershenson MB,Community Action Against Asthma S

更新日期：2018-11-21 00:00:00

abstract：: ...

journal_title：Respiratory research

authors：

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...

journal_title：Respiratory research

authors： Milara J,Díaz-Platas L,Contreras S,Ribera P,Roger I,Ballester B,Montero P,Cogolludo Á,Morcillo E,Cortijo J

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Although a large body of literature is available that describes the effects of smoking, asthma and COPD on lung function, most studies are restricted to a small age range and to one factor. As a consequence, available results are incomplete and often difficult to compare, also due to the ways the effects are...

journal_title：Respiratory research

authors： Chiappa S,Winn J,Viñuela A,Tipney H,Spector TD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. METHODS:Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT sca...

journal_title：Respiratory research

authors： Stockley RA,Parr DG,Piitulainen E,Stolk J,Stoel BC,Dirksen A

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:The identification of smoking-related lung disease in current and former smokers with normal FEV1 is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of ai...

journal_title：Respiratory research

authors： Pirozzi CS,Gu T,Quibrera PM,Carretta EE,Han MK,Murray S,Cooper CB,Tashkin DP,Kleerup EC,Barjaktarevic I,Hoffman EA,Martinez CH,Christenson SA,Hansel NN,Graham Barr R,Bleecker ER,Ortega VE,Martinez FJ,Kanner RE,Paine

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Exposure to cigarette smoke is considered a major risk factor for the development of lung diseases, since its causative role has been assessed in the induction and maintenance of an inflamed state in the airways. Lung fibroblasts can contribute to these processes, due to their ability to produce proinflammat...

journal_title：Respiratory research

authors： La Rocca G,Anzalone R,Magno F,Farina F,Cappello F,Zummo G

更新日期：2007-03-12 00:00:00

abstract：BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...

journal_title：Respiratory research

authors： Yang Q,Soltis AR,Sukumar G,Zhang X,Caohuy H,Freedy J,Dalgard CL,Wilkerson MD,Pollard HB,Pollard BS

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR. METHODS:At baseline and during the 4-year Understanding Potential Long-term Improvements in Function with Tiotropium (UPLIFT®) trial, patie...

journal_title：Respiratory research

authors： Hanania NA,Sharafkhaneh A,Celli B,Decramer M,Lystig T,Kesten S,Tashkin D

更新日期：2011-01-11 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1...

journal_title：Respiratory research

authors： Moosavi SM,Prabhala P,Ammit AJ

更新日期：2017-08-10 00:00:00

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Progestins as respiratory stimulants in chronic obstructive pulmonary disease (COPD) have been investigated in males and during wakefulness. However, sleep and gender may influence therapeutic responses. We investigated the effects of a 2-week medroxyprogesterone acetate (MPA) therapy on sleep and nocturnal ...

journal_title：Respiratory research

authors： Saaresranta T,Aittokallio T,Utriainen K,Polo O

更新日期：2005-04-04 00:00:00

abstract：BACKGROUND:Steroid resistant (SR) asthma is characterized by persistent airway inflammation that fails to resolve despite treatment with high doses of corticosteroids. Furthermore, SR patient airways show increased numbers neutrophils, which are less responsive to glucocorticoid. The present study seeks to determine wh...

journal_title：Respiratory research

authors： Wang M,Gao P,Wu X,Chen Y,Feng Y,Yang Q,Xu Y,Zhao J,Xie J

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Chronic respiratory diseases (CRDs) are leading causes of morbidity worldwide. However, the spatial and temporal trends in prevalence and incidence of CRDs have not been estimated. METHODS:Based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, we analyzed the prevalence and...

journal_title：Respiratory research

authors： Xie M,Liu X,Cao X,Guo M,Li X

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS...

journal_title：Respiratory research

authors： Xie S,Issa R,Sukkar MB,Oltmanns U,Bhavsar PK,Papi A,Caramori G,Adcock I,Chung KF

更新日期：2005-12-16 00:00:00

abstract：BACKGROUND:Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine the clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revealing such association of bacterial genotypes and clinical phenotypes from immigrant rich countrie...

journal_title：Respiratory research

authors： Varghese B,Enani M,Alrajhi A,Al Johani S,Albarak A,Althawadi S,Elkhizzi N,AlGhafli H,Shoukri M,Al-Hajoj S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is a severe form of lung injury characterized by damage to the epithelial barrier with subsequent pulmonary edema and hypoxic respiratory failure. ARDS is a significant medical problem in intensive care units with associated high care costs. There are many potential...

journal_title：Respiratory research

authors： Dolinay T,Aonbangkhen C,Zacharias W,Cantu E,Pogoriler J,Stablow A,Lawrence GG,Suzuki Y,Chenoweth DM,Morrisey E,Christie JD,Beers MF,Margulies SS

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associat...

journal_title：Respiratory research

authors： Wan ES,Castaldi PJ,Cho MH,Hokanson JE,Regan EA,Make BJ,Beaty TH,Han MK,Curtis JL,Curran-Everett D,Lynch DA,DeMeo DL,Crapo JD,Silverman EK,COPDGene Investigators.

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...

journal_title：Respiratory research

authors： Pfarr N,Fischer C,Ehlken N,Becker-Grünig T,López-González V,Gorenflo M,Hager A,Hinderhofer K,Miera O,Nagel C,Schranz D,Grünig E

更新日期：2013-01-09 00:00:00