当前位置： SCI文献检索 > RESPIRATORY RESEARCH期刊下所有文献 > Impaired survival of regulatory T cells in pulmonary sarcoidosis.

Impaired survival of regulatory T cells in pulmonary sarcoidosis.

Abstract：

BACKGROUND:Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. Therefore, the aim of this study is to analyze proportions, phenotype, survival, and apoptotic susceptibility of Tregs in sarcoidosis. METHODS:Patients with pulmonary sarcoidosis (n = 58) were included at time of diagnosis. Tregs were analyzed in broncho-alveolar lavage fluid and peripheral blood of patients and healthy controls (HC). RESULTS:In sarcoidosis patients no evidence was found for a relative deficit of Tregs, neither locally nor systemically. Rather, increased proportions of circulating Tregs were observed, most prominently in patients developing chronic disease. Sarcoidosis circulating Tregs displayed adequate expression of FoxP3, CD25 and CTLA4. Remarkably, in sarcoidosis enhanced CD95 expression on circulating activated CD45RO(+) Tregs was observed compared with HC, and proportions of these cells were significantly increased. Specifically sarcoidosis Tregs--but not Th cells--showed impaired survival compared with HC. Finally, CD95L-mediated apoptosis was enhanced in sarcoidosis Tregs. CONCLUSION:In untreated patients with active pulmonary sarcoidosis, Tregs show impaired survival and enhanced apoptotic susceptibility towards CD95L. Increased apoptosis likely contributes to the insufficient immunosuppressive function of sarcoidosis Tregs. Further research into this field will help determine whether improvement of Treg survival holds a promising new therapeutic approach for chronic sarcoidosis patients.

journal_name

Respir Res

journal_title

Respiratory research

authors

Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B

doi

10.1186/s12931-015-0265-8

subject

Has Abstract

pub_date

2015-09-16 00:00:00

pages

108

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-015-0265-8

journal_volume

16

pub_type

杂志文章

相关文献

RESPIRATORY RESEARCH文献大全
  • Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Cigarette smoke is a major risk factor for chronic obstructive pulmonary disease (COPD), an inflammatory lung disorder. COPD is characterized by an increase in CD8(+) T cells within the central and peripheral airways. We hypothesized that the CD8(+) T cells in COPD patients have increased Toll-like receptor ...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-149

    authors： Nadigel J,Préfontaine D,Baglole CJ,Maltais F,Bourbeau J,Eidelman DH,Hamid Q

    更新日期：2011-11-09 00:00:00

  • Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study.

    abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-014-0152-8

    authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

    更新日期：2014-11-27 00:00:00

  • Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients.

    abstract：BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-1214-8

    authors： Yang Q,Soltis AR,Sukumar G,Zhang X,Caohuy H,Freedy J,Dalgard CL,Wilkerson MD,Pollard HB,Pollard BS

    更新日期：2019-12-21 00:00:00

  • The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF)--practical implications.

    abstract：:Idiopathic pulmonary fibrosis (IPF), the most prevalent idiopathic interstitial pneumonia, is associated with a poor prognosis. An accurate diagnosis of IPF is essential for optimal management. The recent ATS/ERS/JRS/ALAT recommendations on the diagnosis and management of IPF were developed from a systematic review of...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-14-S1-S2

    authors： Wells AU

    更新日期：2013-01-01 00:00:00

  • Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD-a randomised controlled study.

    abstract：BACKGROUND:Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on lung function including body plethysmography. METHODS:This multicentre, randomised, double-blind, si...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12931-016-0498-1

    authors： Salomon J,Stolz D,Domenighetti G,Frey JG,Turk AJ,Azzola A,Sigrist T,Fitting JW,Schmidt U,Geiser T,Wild C,Kostikas K,Clemens A,Brutsche M

    更新日期：2017-01-11 00:00:00

  • Relationship between age and bronchodilator response at diagnosis in adult-onset asthma.

    abstract：BACKGROUND:Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like re...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01441-w

    authors： Tommola M,Won HK,Ilmarinen P,Jung H,Tuomisto LE,Lehtimäki L,Niemelä O,Kim TB,Kankaanranta H

    更新日期：2020-07-13 00:00:00

  • COVID-19 multidisciplinary high dependency unit: the Milan model.

    abstract：:COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory disease rather than a pulmonary disease. The management of hospitalized patients in COVID-19 dedicated units is a...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-020-01516-8

    authors： Aliberti S,Amati F,Pappalettera M,Di Pasquale M,D'Adda A,Mantero M,Gramegna A,Simonetta E,Oneta AM,Privitera E,Gori A,Bozzi G,Peyvandi F,Minoia F,Filocamo G,Abbruzzese C,Vicenzi M,Tagliabue P,Alongi S,Blasi F

    更新日期：2020-10-09 00:00:00

  • Isolation of human beta-defensin-4 in lung tissue and its increase in lower respiratory tract infection.

    abstract：BACKGROUND:Human beta-defensin-4 (hBD-4), a new member of the beta-defensin family, was discovered by an analysis of the genomic sequence. The objective of this study was to clarify hBD-4 expression in human lung tissue, along with the inducible expression in response to infectious stimuli, localization, and antimicrob...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-130

    authors： Yanagi S,Ashitani J,Ishimoto H,Date Y,Mukae H,Chino N,Nakazato M

    更新日期：2005-11-04 00:00:00

  • Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis.

    abstract：BACKGROUND:ExoU, a Pseudomonas aeruginosa cytotoxin with phospholipase A2 activity, was shown to induce vascular hyperpermeability and thrombus formation in a murine model of pneumosepsis. In this study, we investigated the toxin ability to induce alterations in pulmonary fibrinolysis and the contribution of the platel...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-104

    authors： Machado GB,de Oliveira AV,Saliba AM,de Lima CD,Suassuna JH,Plotkowski MC

    更新日期：2011-08-05 00:00:00

  • Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study.

    abstract：BACKGROUND:The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Initiative for Chronic Obstructive Lung Disease (GOLD). Physical activity has emerged as both functional...

    journal_title：Respiratory research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1186/s12931-019-1053-7

    authors： Mihaltan F,Adir Y,Antczak A,Porpodis K,Radulovic V,Pires N,de Vries GJ,Horner A,De Bontridder S,Chen Y,Shavit A,Alecu S,Adamek L

    更新日期：2019-05-14 00:00:00

  • Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017.

    abstract：BACKGROUND:Chronic respiratory diseases (CRDs) are leading causes of morbidity worldwide. However, the spatial and temporal trends in prevalence and incidence of CRDs have not been estimated. METHODS:Based on data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017, we analyzed the prevalence and...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-1291-8

    authors： Xie M,Liu X,Cao X,Guo M,Li X

    更新日期：2020-02-11 00:00:00

  • Indacaterol/glycopyrronium is cost-effective compared to salmeterol/fluticasone in COPD: FLAME-based modelling in a Swedish population.

    abstract：BACKGROUND:This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS:A previously published and valida...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/s12931-017-0688-5

    authors： Bjermer L,van Boven JFM,Costa-Scharplatz M,Keininger DL,Gutzwiller FS,Lisspers K,Mahon R,Olsson P,Roche N

    更新日期：2017-12-11 00:00:00

  • Sex-specific lung functional changes in adult mice exposed only to second-hand smoke in utero.

    abstract：BACKGROUND:An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in utero exposure to SHS at critical stages of fetal development, results in altered lung responses and...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-017-0591-0

    authors： Noël A,Xiao R,Perveen Z,Zaman H,Le Donne V,Penn A

    更新日期：2017-06-27 00:00:00

  • Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients.

    abstract：BACKGROUND:Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced and spontaneous sputum from COPD patients sampled during the same consultation. METHODS:COPD patien...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-017-0645-3

    authors： Tangedal S,Aanerud M,Grønseth R,Drengenes C,Wiker HG,Bakke PS,Eagan TM

    更新日期：2017-08-29 00:00:00

  • Influence of weather and atmospheric pollution on physical activity in patients with COPD.

    abstract：RATIONALE:Information concerning how climate and atmospheric pollutants affects physical activity in COPD patients is lacking and might be valuable in determining when physical activity should be encouraged. METHODS:Seventy-three stable COPD patients recorded on daily diary cards worsening of respiratory symptoms, pea...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-015-0229-z

    authors： Alahmari AD,Mackay AJ,Patel AR,Kowlessar BS,Singh R,Brill SE,Allinson JP,Wedzicha JA,Donaldson GC

    更新日期：2015-06-13 00:00:00

  • Pentraxin 3 promotes airway inflammation in experimental asthma.

    abstract：BACKGROUND:Pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3 deficiency enhances interleukin (IL)-17A-dominant pulmonary inflammation in an ovalbumin (OVA)-induced mouse asthma model. However, whether PTX3 treatment would provide protectio...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01499-6

    authors： Gao P,Tang K,Lu Y,Huang Z,Wang S,Wang M,Wang J,Zhao J,Xie J

    更新日期：2020-09-16 00:00:00

  • Airway regulatory T cells are decreased in COPD with a rapid decline in lung function.

    abstract：BACKGROUND:Differences in the expression of regulatory T cells (Tregs) have been suggested to explain why some smokers develop COPD and some do not. Upregulation of Tregs in response to smoking would restrain airway inflammation and thus the development of COPD; while the absense of such upregulation would over time le...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-020-01593-9

    authors： Eriksson Ström J,Pourazar J,Linder R,Blomberg A,Lindberg A,Bucht A,Behndig AF

    更新日期：2020-12-14 00:00:00

  • Increased plasma mannose binding lectin levels are associated with bronchiolitis obliterans after lung transplantation.

    abstract：BACKGROUND:Long-term lung allograft survival is limited by bronchiolitis obliterans syndrome (BOS). Mannose binding lectin (MBL) belongs to the innate immune system, participates in complement activation, and may predispose to graft rejection. We investigated mannose binding (MBL) during cold ischemia and in tissue sam...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-13-56

    authors： Budd SJ,Aris RM,Medaiyese AA,Tilley SL,Neuringer IP

    更新日期：2012-07-04 00:00:00

  • Association of mast cells with lung function in chronic obstructive pulmonary disease.

    abstract：BACKGROUND:In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in C...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-9-64

    authors： Gosman MM,Postma DS,Vonk JM,Rutgers B,Lodewijk M,Smith M,Luinge MA,Ten Hacken NH,Timens W

    更新日期：2008-09-10 00:00:00

  • Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogene...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-7-64

    authors： Pons J,Sauleda J,Regueiro V,Santos C,López M,Ferrer J,Agustí AG,Bengoechea JA

    更新日期：2006-04-10 00:00:00

  • Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression.

    abstract：BACKGROUND:Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD or if RelB prevents C...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-015-0214-6

    authors： Sheridan JA,Zago M,Nair P,Li PZ,Bourbeau J,Tan WC,Hamid Q,Eidelman DH,Benedetti AL,Baglole CJ

    更新日期：2015-05-06 00:00:00

  • Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease.

    abstract：BACKGROUND:The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD). METHODS:In two double-blind, 52-week studies, ACCLAIM/COPD I (n=843) and II (n=804), patients were randomis...

    journal_title：Respiratory research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1186/1465-9921-12-55

    authors： Jones PW,Rennard SI,Agusti A,Chanez P,Magnussen H,Fabbri L,Donohue JF,Bateman ED,Gross NJ,Lamarca R,Caracta C,Gil EG

    更新日期：2011-04-26 00:00:00

  • Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

    abstract：BACKGROUND:Host-associated microbial communities have important roles in tissue homeostasis and overall health. Severe perturbations can occur within these microbial communities during critical illness due to underlying diseases and clinical interventions, potentially influencing patient outcomes. We sought to profile ...

    journal_title：Respiratory research

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/s12931-018-0950-5

    authors： Lamarche D,Johnstone J,Zytaruk N,Clarke F,Hand L,Loukov D,Szamosi JC,Rossi L,Schenck LP,Verschoor CP,McDonald E,Meade MO,Marshall JC,Bowdish DME,Karachi T,Heels-Ansdell D,Cook DJ,Surette MG,PROSPECT Investigators.,C

    更新日期：2018-12-07 00:00:00

  • Effect of COPD severity and comorbidities on the result of the PHQ-9 tool for the diagnosis of depression: results from the COSYCONET cohort study.

    abstract：:The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed th...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/s12931-019-0997-y

    authors： von Siemens SM,Jörres RA,Behr J,Alter P,Lutter J,Lucke T,Söhler S,Welte T,Watz H,Vogelmeier CF,Trudzinski F,Rief W,Herbig B,Kahnert K,COSYCONET study group.

    更新日期：2019-02-11 00:00:00

  • Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood.

    abstract：BACKGROUND:Although T cells, especially CD8+, have been implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, their role during acute exacerbations (AE-COPD) is uncertain. METHODS:We recruited subjects with COPD and a history of previous AE-COPD and studied them quarterly to collect blood and sponta...

    journal_title：Respiratory research

    pub_type： 临床试验,杂志文章

    doi：10.1186/s12931-015-0251-1

    authors： Freeman CM,Martinez CH,Todt JC,Martinez FJ,Han MK,Thompson DL,McCloskey L,Curtis JL

    更新日期：2015-08-05 00:00:00

  • Weighing the evidence for pharmacological treatment interventions in mild COPD; a narrative perspective.

    abstract：:There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1 or the now-withdrawn GOLD stage 0) represents an early stage of COPD that may progress to more severe disease...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：10.1186/s12931-019-1108-9

    authors： Singh D,D'Urzo AD,Donohue JF,Kerwin EM

    更新日期：2019-07-08 00:00:00

  • Hemodynamic and genetic analysis in children with idiopathic, heritable, and congenital heart disease associated pulmonary arterial hypertension.

    abstract：BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-14-3

    authors： Pfarr N,Fischer C,Ehlken N,Becker-Grünig T,López-González V,Gorenflo M,Hager A,Hinderhofer K,Miera O,Nagel C,Schranz D,Grünig E

    更新日期：2013-01-09 00:00:00

  • Signaling and regulation of G protein-coupled receptors in airway smooth muscle.

    abstract：:Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that ...

    journal_title：Respiratory research

    pub_type： 杂志文章,评审

    doi：

    authors： Billington CK,Penn RB

    更新日期：2003-01-01 00:00:00

  • Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study.

    abstract：BACKGROUND:The receptor for advanced glycation end products (RAGE) is a multiligand signal transduction receptor that can initiate and perpetuate inflammation. Its soluble isoform (sRAGE) acts as a decoy receptor for RAGE ligands, and is thought to afford protection against inflammation. With the present study, we aime...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-12-37

    authors： Miniati M,Monti S,Basta G,Cocci F,Fornai E,Bottai M

    更新日期：2011-03-30 00:00:00

  • Pathophysiological classification of chronic rhinosinusitis.

    abstract：BACKGROUND:Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis (CRS) differential diagnosis. However, the classification and mechanisms of different CRS phenotypes remains problematic. METHOD:Statistical patterns of subjective and objective findings were assessed by retrospective chart re...

    journal_title：Respiratory research

    pub_type： 杂志文章

    doi：10.1186/1465-9921-6-149

    authors： Baraniuk JN,Maibach H

    更新日期：2005-12-19 00:00:00