Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication.

abstract：BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

journal_title：Respiratory research

authors： Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:Several studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in insomnia sufferers. Thus, the aim of this study was to examine the pr...

journal_title：Respiratory research

authors： Hein M,Lanquart JP,Loas G,Hubain P,Linkowski P

更新日期：2017-07-06 00:00:00

abstract：BACKGROUND:Motor vehicle-related air pollution can potentially impair lung function. The effect of pollution in people with compromised pulmonary function such as in COPD has not been previously investigated. To examine the association of lung function with motor vehicle density in people with spirometrically determine...

journal_title：Respiratory research

authors： Nitschke M,Appleton SL,Li Q,Tucker GR,Shah P,Bi P,Pisaniello DL,Adams RJ

更新日期：2016-10-24 00:00:00

abstract：:There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of this manuscript is to systematically review the current knowledge on exhaled VOCs with respect to their poten...

journal_title：Respiratory research

authors： van de Kant KD,van der Sande LJ,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-21 00:00:00

abstract：BACKGROUND:Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popula...

journal_title：Respiratory research

authors： Dinh PC,Cores J,Hensley MT,Vandergriff AC,Tang J,Allen TA,Caranasos TG,Adler KB,Lobo LJ,Cheng K

更新日期：2017-06-30 00:00:00

abstract：BACKGROUND:Airway absorption and bioavailability of inhaled corticosteroids (ICSs) may be influenced by differences in pharmacokinetic properties such as lipophilicity and patient characteristics such as lung function. This study aimed to further investigate and clarify the distribution of budesonide and fluticasone in...

journal_title：Respiratory research

authors： Dalby C,Polanowski T,Larsson T,Borgström L,Edsbäcker S,Harrison TW

更新日期：2009-10-31 00:00:00

abstract：:Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs' surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which...

journal_title：Respiratory research

authors： Carreto-Binaghi LE,Aliouat el M,Taylor ML

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate p...

journal_title：Respiratory research

authors： Zhu Y,Liu X,Sköld CM,Wang H,Kohyama T,Wen FQ,Ertl RF,Rennard SI

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, remains however unknown. METHODS:The present study investigated the role of intracellular signalling a...

journal_title：Respiratory research

authors： Chanteux H,Guisset AC,Pilette C,Sibille Y

更新日期：2007-10-04 00:00:00

abstract：RESEARCH QUESTION:There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment. PATIENTS A...

journal_title：Respiratory research

authors： Pastre J,Barnett S,Ksovreli I,Taylor J,Brown AW,Shlobin OA,Ahmad K,Khangoora V,Aryal S,King CS,Nathan SD

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Although a large body of literature is available that describes the effects of smoking, asthma and COPD on lung function, most studies are restricted to a small age range and to one factor. As a consequence, available results are incomplete and often difficult to compare, also due to the ways the effects are...

journal_title：Respiratory research

authors： Chiappa S,Winn J,Viñuela A,Tipney H,Spector TD

更新日期：2013-05-30 00:00:00

abstract：BACKGROUND:Deep inspirations (DI) have bronchodilatory and bronchoprotective effects in healthy human subjects, but these effects appear to be absent in asthmatic lungs. We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic air...

journal_title：Respiratory research

authors： Jonasson S,Swedin L,Lundqvist M,Hedenstierna G,Dahlén SE,Hjoberg J

更新日期：2008-02-28 00:00:00

abstract：BACKGROUND:Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mut...

journal_title：Respiratory research

authors： Fajac I,Viel M,Sublemontier S,Hubert D,Bienvenu T

更新日期：2008-05-28 00:00:00

abstract：BACKGROUND:This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS:A previously published and valida...

journal_title：Respiratory research

authors： Bjermer L,van Boven JFM,Costa-Scharplatz M,Keininger DL,Gutzwiller FS,Lisspers K,Mahon R,Olsson P,Roche N

更新日期：2017-12-11 00:00:00

abstract：BACKGROUND:Allergen-containing subpollen particles (SPP) are released from whole plant pollen upon contact with water or even high humidity. Because of their size SPP can preferentially reach the lower airways where they come into contact with surfactant protein (SP)-D. Our previous work demonstrated that SP-D increase...

journal_title：Respiratory research

authors： Schleh C,Erpenbeck VJ,Winkler C,Lauenstein HD,Nassimi M,Braun A,Krug N,Hohlfeld JM

更新日期：2010-06-22 00:00:00

abstract：BACKGROUND:Recent trials demonstrate increased pneumonia risk in chronic obstructive pulmonary disease patients treated with the inhaled corticosteroid (ICS) fluticasone propionate (FP). There is limited work describing FP effects on host defenses against bacterial pneumonia. METHODS:C57BL/6 mice received daily, nose-...

journal_title：Respiratory research

authors： Patterson CM,Morrison RL,D'Souza A,Teng XS,Happel KI

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS...

journal_title：Respiratory research

authors： Xie S,Issa R,Sukkar MB,Oltmanns U,Bhavsar PK,Papi A,Caramori G,Adcock I,Chung KF

更新日期：2005-12-16 00:00:00

abstract：BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

journal_title：Respiratory research

authors： Ren Z,Hu Y,Xu L

更新日期：2019-10-16 00:00:00

abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

journal_title：Respiratory research

authors： Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

更新日期：2020-08-08 00:00:00

abstract：BACKGROUND:The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling process in wound healing and disease development. However, the involvement of bronchial epithelial ...

journal_title：Respiratory research

authors： Ishikawa S,Ishimori K,Ito S

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expre...

journal_title：Respiratory research

authors： André PA,Prêle CM,Vierkotten S,Carnesecchi S,Donati Y,Chambers RC,Pache JC,Crestani B,Barazzone-Argiroffo C,Königshoff M,Laurent GJ,Irminger-Finger I

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

journal_title：Respiratory research

authors： Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

更新日期：2006-03-10 00:00:00

abstract：BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...

journal_title：Respiratory research

authors： Lee AG,Le Grand B,Hsu HL,Chiu YM,Brennan KJ,Bose S,Rosa MJ,Brunst KJ,Kloog I,Wilson A,Schwartz J,Morgan W,Coull BA,Wright RO,Baccarelli AA,Wright RJ

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Growing evidences suggested that the Mycobacterium tuberculosis complex (MTBC) lineages can determine the clinical outcome of pulmonary and extra-pulmonary tuberculosis. However, limited data only available revealing such association of bacterial genotypes and clinical phenotypes from immigrant rich countrie...

journal_title：Respiratory research

authors： Varghese B,Enani M,Alrajhi A,Al Johani S,Albarak A,Althawadi S,Elkhizzi N,AlGhafli H,Shoukri M,Al-Hajoj S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR. METHODS:At baseline and during the 4-year Understanding Potential Long-term Improvements in Function with Tiotropium (UPLIFT®) trial, patie...

journal_title：Respiratory research

authors： Hanania NA,Sharafkhaneh A,Celli B,Decramer M,Lystig T,Kesten S,Tashkin D

更新日期：2011-01-11 00:00:00

abstract：:Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted i...

journal_title：Respiratory research

authors： Roche N,Deslée G,Caillaud D,Brinchault G,Court-Fortune I,Nesme-Meyer P,Surpas P,Escamilla R,Perez T,Chanez P,Pinet C,Jebrak G,Paillasseur JL,Burgel PR,INITIATIVES BPCO Scientific Committee.

更新日期：2014-02-17 00:00:00

abstract：:Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medline/PubMed to ident...

journal_title：Respiratory research

authors： Kankaanranta H,Lahdensuo A,Moilanen E,Barnes PJ

更新日期：2004-10-27 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible chronic inflammatory disease of the lung. The nature of the immune reaction in COPD raises the possibility that IL-17 and related cytokines may contribute to this disorder. This study analyzed the expression of IL-17A and IL-17F a...

journal_title：Respiratory research

authors： Chang Y,Nadigel J,Boulais N,Bourbeau J,Maltais F,Eidelman DH,Hamid Q

更新日期：2011-04-10 00:00:00

abstract：BACKGROUND:Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading to airway remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role in airway remodeling through the acquisition of a mesenchymal phenotype in airway epithelial cells. TGF-β1 is kno...

journal_title：Respiratory research

authors： Johnson JR,Nishioka M,Chakir J,Risse PA,Almaghlouth I,Bazarbashi AN,Plante S,Martin JG,Eidelman D,Hamid Q

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Functional deterioration in cystic fibrosis (CF) may be reflected by increasing bronchial obstruction and, as recently shown, by ventilation inhomogeneities. This study investigated which physiological factors (airway obstruction, ventilation inhomogeneities, pulmonary hyperinflation, development of trapped ...

journal_title：Respiratory research

authors： Kraemer R,Baldwin DN,Ammann RA,Frey U,Gallati S

更新日期：2006-11-30 00:00:00