Multiple functions of microsomal triglyceride transfer protein.

Abstract:

: Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the realization that abetalipoproteinemia patients carry mutations in the MTTP gene resulting in the loss of its lipid transfer activity. Now it is known that it also plays a role in the biosynthesis of CD1, glycolipid presenting molecules, as well as in the regulation of cholesterol ester biosynthesis. In this review, we will provide a historical perspective about the identification, purification and characterization of MTP, describe methods used to measure its lipid transfer activity, and discuss tissue expression and function. Finally, we will review the role MTP plays in the assembly of apoB-lipoprotein, the regulation of cholesterol ester synthesis, biosynthesis of CD1 proteins and propagation of hepatitis C virus. We will also provide a brief overview about the clinical potentials of MTP inhibition.

journal_name

Nutr Metab (Lond)

journal_title

Nutrition & metabolism

authors

Hussain MM,Rava P,Walsh M,Rana M,Iqbal J

doi

10.1186/1743-7075-9-14

subject

Has Abstract

pub_date

2012-02-21 00:00:00

pages

14

issn

1743-7075

pii

1743-7075-9-14

journal_volume

9

pub_type

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