Abstract:
: Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the realization that abetalipoproteinemia patients carry mutations in the MTTP gene resulting in the loss of its lipid transfer activity. Now it is known that it also plays a role in the biosynthesis of CD1, glycolipid presenting molecules, as well as in the regulation of cholesterol ester biosynthesis. In this review, we will provide a historical perspective about the identification, purification and characterization of MTP, describe methods used to measure its lipid transfer activity, and discuss tissue expression and function. Finally, we will review the role MTP plays in the assembly of apoB-lipoprotein, the regulation of cholesterol ester synthesis, biosynthesis of CD1 proteins and propagation of hepatitis C virus. We will also provide a brief overview about the clinical potentials of MTP inhibition.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Hussain MM,Rava P,Walsh M,Rana M,Iqbal Jdoi
10.1186/1743-7075-9-14subject
Has Abstractpub_date
2012-02-21 00:00:00pages
14issn
1743-7075pii
1743-7075-9-14journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the di...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-44
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This stu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-47
更新日期:2012-05-30 00:00:00
abstract:BACKGROUND:Endothelial dysfunction (ED) is an independent predictor of cardiovascular events. ED is also a reversible disorder, and nitric oxide donors like L-arginine may promote this process. Despite the positive results from several studies, there are some studies that have shown that L-arginine administration did n...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-13
更新日期:2009-03-24 00:00:00
abstract:Background:Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte beige cells, involved in so-called white adipocyte tissue (WAT) browning, has rec...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0373-4
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-51
更新日期:2014-10-24 00:00:00
abstract:BACKGROUND:The composition of dietary fatty acids (FA) during early life may impact adult adipose tissue (AT) development. We investigated the effects of alpha-linolenic acid (ALA) intake during the suckling/weaning period on AT development and metabolic markers in the guinea pig (GP). METHODS:Newborn GP were fed a 27...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-8
更新日期:2010-01-29 00:00:00
abstract:: Liver steatosis is a frequent histological feature in patients chronically infected with hepatitis C virus (HCV). The relationship between HCV and hepatic steatosis seems to be the result of both epigenetic and genetic factors. In vivo and in vitro studies have shown that HCV can alter intrahepatic lipid metabolism b...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-13
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-50
更新日期:2011-07-12 00:00:00
abstract:UNLABELLED: BACKGROUND:It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in an animal model of the metabolic syndrome to identify the molecular targets associated...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-87
更新日期:2012-09-21 00:00:00
abstract:Background:Diet and exercise play important roles in ameliorating metabolic syndrome. Yunkang 10 (Camellia sinensis var. assamica) is a most cultivated tea variety for making tea in the Southwestern China. Currently, there is no report of healthy effects of Yunkang 10 green tea (YKGT) and treadmill exercise (Ex) on hig...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0433-9
更新日期:2020-02-04 00:00:00
abstract:Background:Caloric restriction since birth changes glucose metabolism by the liver in overnight-fasted rats to a fed-like pattern, in which glucose output is large but gluconeogenesis is negligible. It was investigated whether these changes could be a residual effect of the nutritional condition during lactation and wh...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0413-0
更新日期:2019-12-12 00:00:00
abstract::Glucocorticoids are stress hormones that modulate a large number of physiological actions involved in metabolic, inflammatory, cardiovascular and behavioral processes. The molecular mechanisms and the physiological effects of glucocorticoids have been extensively studied. However, the involvement of glucocorticoid act...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-2-3
更新日期:2005-02-02 00:00:00
abstract:BACKGROUND:Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We re...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-33
更新日期:2010-04-22 00:00:00
abstract:Background:The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores. Methods:In this study, we enrolled 220 vegetarians and 220 o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00484-6
更新日期:2020-08-03 00:00:00
abstract:Background:The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet indu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0249-z
更新日期:2018-02-17 00:00:00
abstract:PURPOSE:To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women. METHODS:Menstrual history, oral contraceptive use, exercise history, and nutritional factors including calcium, c...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-17
更新日期:2007-08-06 00:00:00
abstract:: Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially di...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-63
更新日期:2012-06-27 00:00:00
abstract::Propolis is a sticky, resinous material gather from plants and is blended with wax and other constituents. It is reported to have anti-inflammatory, anti-oxidative and blood glucose-lowering properties. This review aims to summarise evidences for the cellular and molecular mechanism of Propolis in inflammation, oxidat...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00485-5
更新日期:2020-08-12 00:00:00
abstract:Background:To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C and Ln TG/HDL-C, over an approximate 3 year duration, on incident type...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0287-6
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-91
更新日期:2011-12-20 00:00:00
abstract:BACKGROUND:Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant. Currently, no method allows simple, direct quantification of holotranscobalamin. We now report on the identificat...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-3-3
更新日期:2006-01-04 00:00:00
abstract:BACKGROUND:Many publications link high homocysteine levels to cardiovascular disease. In Spain there is little information on the prevalence of hyperhomocysteinaemia and associated vitamin factors among the general population, and less still among children. Cardiovascular risk factors in the childhood population may be...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-39
更新日期:2009-10-05 00:00:00
abstract:BACKGROUND:The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio and IR in the Chinese population. Here, we aimed to explore whether the ALT/AST ratio is associated an...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0219-x
更新日期:2017-10-10 00:00:00
abstract::An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, P...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,评审
doi:10.1186/s12986-017-0233-z
更新日期:2017-12-22 00:00:00
abstract:Background:The health benefits of dietary fibre (DF) intake on non-alcoholic fatty liver disease (NAFLD) are controversial. Thus, this large cross-sectional study aimed to determine the associations between DF intake and the prevalence of newly-diagnosed NAFLD in a large general population. Methods:A total of 23,529 p...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0420-1
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-22
更新日期:2007-10-30 00:00:00
abstract:BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatitis (NASH). METHODS:We set up a prokaryotic expression system and purified the recombinant SFRP5 pro...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0208-0
更新日期:2017-08-15 00:00:00
abstract:Background:It is well known that ingestion of protein sources can stimulate muscle protein synthesis (MPS). The intake of whey protein is highly effective especially for accelerating MPS. Whey protein hydrolysate (WPH) can raise postprandial plasma concentration of amino acids, which impact stimulation of MPS more rapi...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0417-9
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:The conjugated linoleic acid (CLA) content of beef can be increased by supplementing appropriate beef cattle diets with vegetable oil or oil seed. Yet the effect of consumption of such beef on adipose tissue characteristics is unclear, thus the study was conducted to compare adipose tissue responses of rats ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-19
更新日期:2009-04-22 00:00:00
abstract:BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-016-0103-0
更新日期:2016-06-29 00:00:00