Abstract:
Background:It is well known that ingestion of protein sources can stimulate muscle protein synthesis (MPS). The intake of whey protein is highly effective especially for accelerating MPS. Whey protein hydrolysate (WPH) can raise postprandial plasma concentration of amino acids, which impact stimulation of MPS more rapidly and highly than intact whey protein. However, it is unclear which is more effective for stimulating MPS, WPH or intact whey protein. The aim of the present study was to compare the effects of the WPH and whey protein on MPS in rats after exercise. Methods:Rats were first subjected to a 2 h. swimming protocol. After this, in experiment 1, we evaluated time-dependent changes in the fractional synthetic rate (FSR) of the triceps muscle in Male Sprague-Dawley rats after ingestion of intact whey protein (30, 60, 90 or 120 min after ingestion). Then in experiment 2, at the time point that the results of Experiment 1 revealed postprandial FSR was highest (60 min after ingestion), we measured the FSR after ingestion of the WPH or whey protein at two different doses (0.5 or 2.0 g protein/kg body weight), or with deionized water (control), again after exercise. Plasma components and mammalian target of rapamycin (mTOR) signaling were also measured. Results:In experiment 1, postprandial FSR was highest 60 min after whey protein was administered. In experiment 2, the FSR 60 min after ingestion of the WPH was higher than that of whey protein (significant treatment main effect). Moreover, at a lower dose, only the WPH ingestion caused greater MPS and phosphorylated 4E-binding protein 1 (4E-BP1) levels compared with the control group. Conclusion:These results indicate that ingestion of the WPH was associated with greater post-exercise MPS compared with intact whey protein, especially at lower doses.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Nakayama K,Tagawa R,Saito Y,Sanbongi Cdoi
10.1186/s12986-019-0417-9subject
Has Abstractpub_date
2019-12-27 00:00:00pages
90issn
1743-7075pii
417journal_volume
16pub_type
杂志文章abstract:Background:Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. Objective:To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Methods:Forty-five rats were divided randomly into three group...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0395-y
更新日期:2019-10-30 00:00:00
abstract::An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, P...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,评审
doi:10.1186/s12986-017-0233-z
更新日期:2017-12-22 00:00:00
abstract:Background:Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myocardial apo...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0432-x
更新日期:2020-01-31 00:00:00
abstract:Background:Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type transition. In this study, we assessed the effects of natural flavonoid myricetin on exercise endur...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0353-8
更新日期:2019-05-02 00:00:00
abstract:: Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,收录出版
doi:10.1186/1743-7075-5-27
更新日期:2008-10-18 00:00:00
abstract:Background:We previously reported on the anti-obesogenic and anti-inflammatory effects associated with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in our diet-induced obesity (DIO) mouse model. Two isocaloric high-fat diets (HFDs; 48 kJ% fat), HFD (HF) and n-3 LCPUFA-enriched HFD (HF/n-3), and a control diet (C...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0291-x
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVE:Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-63
更新日期:2011-09-19 00:00:00
abstract:Background:NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives,...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0223-1
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate whether two variants of the TCF7L2 (rs7903146 and rs12255372) modify the association between nut consumption and the risk of metabolic syndrome (MetS). Additionally, the modifying effect of weight change during follow-up on these associations was investigated. MATERI...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-021-00542-7
更新日期:2021-01-12 00:00:00
abstract:BACKGROUND:A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-50
更新日期:2014-10-18 00:00:00
abstract:BACKGROUND:Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and steatohepatitis (NASH) result ultimately in fibrosis and cirrhosis, the molecular basis for lipid dropl...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-015-0012-7
更新日期:2015-05-20 00:00:00
abstract:PURPOSE:To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women. METHODS:Menstrual history, oral contraceptive use, exercise history, and nutritional factors including calcium, c...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-17
更新日期:2007-08-06 00:00:00
abstract:BACKGROUND:The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio and IR in the Chinese population. Here, we aimed to explore whether the ALT/AST ratio is associated an...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0219-x
更新日期:2017-10-10 00:00:00
abstract:BACKGROUND:The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS:In this case-control study, we included a total of 146 patients with DR and 148 without DR. The i...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-016-0099-5
更新日期:2016-06-04 00:00:00
abstract::Although feeding deficits have been reported in snakes and lizards following vomeronasal system disruption, no deficit has been previously reported in a mammal. We tested gray short-tailed opossums with items from four different food categories prior to occluding access to the vomeronasal organ. Preoperatively, opossu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-2-6
更新日期:2005-02-22 00:00:00
abstract:BACKGROUND:A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-22
更新日期:2007-10-30 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12986-016-0154-2.]. ...
journal_title:Nutrition & metabolism
pub_type: 已发布勘误
doi:10.1186/s12986-017-0192-4
更新日期:2017-06-14 00:00:00
abstract:: This paper reviews evidence in the context of current research linking dietary fructose to health risk markers.Fructose intake has recently received considerable media attention, most of which has been negative. The assertion has been that dietary fructose is less satiating and more lipogenic than other sugars. Howev...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-82
更新日期:2010-11-04 00:00:00
abstract:Objective:This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders. Methods:We searched the following databases until N...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,评审
doi:10.1186/s12986-018-0274-y
更新日期:2018-06-05 00:00:00
abstract:UNLABELLED: BACKGROUND:It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in an animal model of the metabolic syndrome to identify the molecular targets associated...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-87
更新日期:2012-09-21 00:00:00
abstract:BACKGROUND:DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B12 and folate pathways are involved in the production of S-Adenosylmethionine, the universal methyl donor. FINDINGS:Brain vitamin B12 concentration and global DNA methylation was ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-41
更新日期:2012-05-18 00:00:00
abstract::Propolis is a sticky, resinous material gather from plants and is blended with wax and other constituents. It is reported to have anti-inflammatory, anti-oxidative and blood glucose-lowering properties. This review aims to summarise evidences for the cellular and molecular mechanism of Propolis in inflammation, oxidat...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00485-5
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS:Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycem...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0198-y
更新日期:2017-07-05 00:00:00
abstract:BACKGROUND:Dietary n-3-polyunsaturated fatty acids (n-3-PUFA) have been shown to reduce body weight and fat mass in rodents as well as in humans in one small short-term study. We conducted this controlled randomized dietary trial to test the hypothesis that n-3-PUFA lower body weight and fat mass by reducing appetite a...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-24
更新日期:2009-05-29 00:00:00
abstract:: Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce SM and DAG, thereby regulating lipid messengers which play a role in cell survival and apoptosis. Furthermore, its product SM has ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-89
更新日期:2011-12-14 00:00:00
abstract:BACKGROUND:Although evidence indicates that fatty acids (FA) can affect insulin resistance (IR), not all FA contribute equally to the process. Indeed, monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) are reported to reduce IR, whereas saturated FA (SFA) and trans FA appear to increase IR. However, it is not yet ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-10-42
更新日期:2013-06-17 00:00:00
abstract:Background:Nut consumption has been shown to reduce the risk of cardiovascular disease. However, its role in the prevention of metabolic disorders, such as metabolic syndrome (Mets) and overweight/obesity, remains controversial. We therefore conducted a meta-analysis to determine the association of nut consumption with...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0282-y
更新日期:2018-06-22 00:00:00
abstract:BACKGROUND:The protective effect of HDL is mostly attributed to their metabolic function in reverse cholesterol transport (RCT), a process whereby excess cellular cholesterol is taken up from peripheral cells, processed in HDL particles, and later delivered to the liver for further metabolism and biliary secretion. Mec...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-10-67
更新日期:2013-11-06 00:00:00
abstract:Background:To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C and Ln TG/HDL-C, over an approximate 3 year duration, on incident type...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0287-6
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS). To find biomarkers of calcium deficiency and further confirm these biomarkers in serum, we p...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00507-2
更新日期:2020-11-23 00:00:00