Abstract：
: Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce SM and DAG, thereby regulating lipid messengers which play a role in cell survival and apoptosis. Furthermore, its product SM has been implicated in atherogenic processes such as retention of lipoproteins in the blood vessel intima. There are two mammalian sphingomyelin synthases: SMS1 and SMS2. SMS1 is found exclusively in the Golgi at steady state, whereas SMS2 exists in the Golgi and plasma membrane. Conventional motifs responsible for protein targeting to the plasma membrane or Golgi are either not present in, or unique to, SMS1 and SMS2. In this study, we examined how SMS1 and SMS2 achieve their respective subcellular localization patterns. Brefeldin A treatment prevented SMS1 and SMS2 from exiting the ER, demonstrating that they transit through the classical secretory pathway. We created truncations and chimeras of SMS1 and SMS2 to define their targeting signals. We found that SMS1 contains a C-terminal Golgi targeting signal and that SMS2 contains a C-terminal plasma membrane targeting signal.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Yeang C,Ding T,Chirico WJ,Jiang XCdoi
10.1186/1743-7075-8-89subject
Has Abstractpub_date
2011-12-14 00:00:00pages
89issn
1743-7075pii
1743-7075-8-89journal_volume
8pub_type
杂志文章abstract：: Dietary ratios of omega-3 (n-3) to omega-6 (n-6) polyunsaturated fatty acids (PUFAs) have been implicated in controlling markers of the metabolic syndrome, including insulin sensitivity, inflammation, lipid profiles and adiposity. However, the role of dietary PUFAs in regulating energy systems in healthy relative to ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-53
更新日期：2010-06-28 00:00:00
abstract：BACKGROUND:We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS:Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycem...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0198-y
更新日期：2017-07-05 00:00:00
abstract：BACKGROUND:Body volume expands with the positive energy balance associated with the development of adult human obesity and this "growth" is captured by two widely used clinical metrics, waist circumference and body mass index (BMI). Empirical correlations between circumferences, BMI, and related body compartments are f...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-5-24
更新日期：2008-10-06 00:00:00
abstract：BACKGROUND:Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We re...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-33
更新日期：2010-04-22 00:00:00
abstract：BACKGROUND:The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS:In this case-control study, we included a total of 146 patients with DR and 148 without DR. The i...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0099-5
更新日期：2016-06-04 00:00:00
abstract：:Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-13
更新日期：2014-03-19 00:00:00
abstract：: Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturb...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-36
更新日期：2012-04-26 00:00:00
abstract：BACKGROUND:Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and steatohepatitis (NASH) result ultimately in fibrosis and cirrhosis, the molecular basis for lipid dropl...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-015-0012-7
更新日期：2015-05-20 00:00:00
abstract：Background:Consumption of diet high in soy products is suggested to contribute to lower prostate cancer incidence in Asian men. But little has been known about the influences of dietary patterns on gut microbiota and microbiota-mediated isoflavone metabolism. Here, we determined the influences of western pattern diet o...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0351-x
更新日期：2019-04-11 00:00:00
abstract：BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatitis (NASH). METHODS:We set up a prokaryotic expression system and purified the recombinant SFRP5 pro...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0208-0
更新日期：2017-08-15 00:00:00
abstract：BACKGROUND:Adipocyte volume (fat accumulation) and cell number (adipogenesis) is increased in obese individuals. Our objective was the identification of dietary constituents with inhibitory effects on triglyceride formation during adipogenesis. Therefore an in vitro adipose cell assay in murine C3H10 T1/2 cells was dev...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-30
更新日期：2011-05-12 00:00:00
abstract：Objective:We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace to reference measurement procedure. Materials and methods:From January 2018 to June 2019, a total of 4775 southern ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-0427-7
更新日期：2020-01-17 00:00:00
abstract：Background:The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores. Methods:In this study, we enrolled 220 vegetarians and 220 o...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00484-6
更新日期：2020-08-03 00:00:00
abstract：BACKGROUND:Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation of cytosolic mTORC1 to the lysosomal surface is required to stimulate mTORC1 kinase activity. Howeve...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0187-1
更新日期：2017-05-11 00:00:00
abstract：BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-51
更新日期：2014-10-24 00:00:00
abstract：:Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
doi：10.1186/s12986-016-0109-7
更新日期：2016-08-08 00:00:00
abstract：Background:High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development of heart failure and diabetic cardiomyopathy. High-density lipoprotein (HDL) has been reported to p...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0356-5
更新日期：2019-05-28 00:00:00
abstract：BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-50
更新日期：2011-07-12 00:00:00
abstract：BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects o...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-91
更新日期：2011-12-20 00:00:00
abstract：Background:It is not clear whether the frequently reported phenomenon of exercise-induced anorexia is exacerbated or blunted in warm or cold environments. Therefore, this study investigated the effects of exercise in three different environmental temperatures vs. rest, on perceptions of appetite, appetite regulating ho...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0348-5
更新日期：2019-05-06 00:00:00
abstract：UNLABELLED: BACKGROUND:It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in an animal model of the metabolic syndrome to identify the molecular targets associated...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-87
更新日期：2012-09-21 00:00:00
abstract：Background:To investigate the association between different obesity phenotypes and the risk of incident hypertension among both genders. Methods:The study population included 3659 Iranians (men = 1540), aged ≥20 years free of hypertension at baseline. Participants were classified into six categories of body mass index...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0340-0
更新日期：2019-02-27 00:00:00
abstract：: A large volume of human clinical data supports increased dietary protein for favorable changes to body composition, but not all data are conclusive. The aim of this review is to propose two theories, "protein spread theory" and "protein change theory" in an effort to explain discrepancies in the literature. Protein s...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-81
更新日期：2012-09-12 00:00:00
abstract：: Calorie restriction (CR; ~60% of ad libitum, AL intake) has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditional endocrine tissues, including skeletal muscle and other tissues, have been discovered to modulate energy m...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-90
更新日期：2012-10-15 00:00:00
abstract：: Liver steatosis is a frequent histological feature in patients chronically infected with hepatitis C virus (HCV). The relationship between HCV and hepatic steatosis seems to be the result of both epigenetic and genetic factors. In vivo and in vitro studies have shown that HCV can alter intrahepatic lipid metabolism b...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-13
更新日期：2010-02-23 00:00:00
abstract：BACKGROUND:Although evidence indicates that fatty acids (FA) can affect insulin resistance (IR), not all FA contribute equally to the process. Indeed, monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) are reported to reduce IR, whereas saturated FA (SFA) and trans FA appear to increase IR. However, it is not yet ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-10-42
更新日期：2013-06-17 00:00:00
abstract：BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the di...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-44
更新日期：2014-09-15 00:00:00
abstract：Background:Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte beige cells, involved in so-called white adipocyte tissue (WAT) browning, has rec...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0373-4
更新日期：2019-07-16 00:00:00
abstract：UNLABELLED: BACKGROUND:Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbe...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-109
更新日期：2012-12-05 00:00:00
abstract：:We studied the regulation of brain acetyl CoA carboxylase (ACC) activity during food deprivation and under the influence of hormones of glucose homeostasis: glucagon and insulin. Mice were deprived of food and water for time periods of 1, 3, 6, 9, 12 and 24 hours and were then allowed to re-feed for 5, 30 and 60 minut...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-3-15
更新日期：2006-02-16 00:00:00
