Abstract：
BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated with immunosuppression and increased pathogen replication. RESULTS:Our results show that monocytes and macrophages are significantly increased in the bone marrow and blood of mice fed on a protein low diet. No alteration in the capacity of bone marrow derived macrophages isolated from malnourished mice to phagocytose particles, to produce the microbicidal molecule nitric oxide and to kill intracellular Leishmania parasites was detected. However, macrophages and monocytes from malnourished mice express significantly more arginase both in vitro and in vivo. Using an experimental model of visceral leishmaniasis, we show that following protein energy malnutrition, the increased parasite burden measured in the spleen of these mice coincided with increased arginase activity and that macrophages provide a more permissive environment for parasite growth. CONCLUSIONS:Taken together, these results identify a novel mechanism in protein energy malnutrition that might contributes to increased susceptibility to infectious diseases by upregulating arginase activity in myeloid cells.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Corware K,Yardley V,Mack C,Schuster S,Al-Hassi H,Herath S,Bergin P,Modolell M,Munder M,Müller I,Kropf Pdoi
10.1186/1743-7075-11-51subject
Has Abstractpub_date
2014-10-24 00:00:00pages
51issue
1issn
1743-7075pii
622journal_volume
11pub_type
杂志文章abstract：Background:High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development of heart failure and diabetic cardiomyopathy. High-density lipoprotein (HDL) has been reported to p...
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pub_type： 杂志文章
doi：10.1186/s12986-019-0356-5
更新日期：2019-05-28 00:00:00
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pub_type： 杂志文章
doi：10.1186/1743-7075-8-84
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pub_type： 杂志文章
doi：10.1186/s12986-018-0291-x
更新日期：2018-09-26 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12986-018-0282-y
更新日期：2018-06-22 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-021-00542-7
更新日期：2021-01-12 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12986-017-0223-1
更新日期：2017-11-13 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-06-05 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12986-018-0268-9
更新日期：2018-05-02 00:00:00
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更新日期：2010-11-04 00:00:00
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更新日期：2012-04-26 00:00:00
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更新日期：2018-07-09 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-90
更新日期：2012-10-15 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12986-018-0249-z
更新日期：2018-02-17 00:00:00
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pub_type： 杂志文章
doi：10.1186/1743-7075-1-13
更新日期：2004-11-08 00:00:00
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pub_type： 社论
doi：10.1186/1743-7075-5-10
更新日期：2008-04-09 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-56
更新日期：2011-08-11 00:00:00
abstract：UNLABELLED: BACKGROUND:It has been suggested that Sorghum, a rich source of phytochemicals, has a hypoglycemic effect, but the mechanism is unknown. We investigated the effects of oral administration of sorghum extract (SE) on hepatic gluconeogenesis and the glucose uptake of muscle in streptozotocin-induced diabetic ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-106
更新日期：2012-11-27 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
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更新日期：2016-08-08 00:00:00
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更新日期：2015-06-06 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-13
更新日期：2014-03-19 00:00:00
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更新日期：2018-07-11 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-89
更新日期：2011-12-14 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-47
更新日期：2012-05-30 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0417-9
更新日期：2019-12-27 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12986-019-0395-y
更新日期：2019-10-30 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-6-24
更新日期：2009-05-29 00:00:00
abstract：BACKGROUND:From a health promotion perspective, the use of dietary indices is preferred above single nutrients and foods to evaluate diet quality. Longitudinal research about the association between dietary indices and respectively anthropometric parameters and blood lipids is lacking. The aim of this study was to inve...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-015-0042-1
更新日期：2015-11-19 00:00:00
