Abstract:
: Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturbances, including hypertension, dyslipidemia and the anorexia-cachexia syndrome which are linked to poor outcomes. Specific hormonal, inflammatory, and nutritional-metabolic factors may play key roles in CKD development and pathogenesis. These include raised proinflammatory cytokines, such as interleukin-1 and -6, tumor necrosis factor, altered hepatic acute phase proteins, including reduced albumin, increased C-reactive protein, and perturbations in normal anabolic hormone responses with reduced growth hormone-insulin-like growth factor-1 axis activity. Others include hyperactivation of the renin-angiotensin aldosterone system (RAAS), with angiotensin II and aldosterone implicated in hypertension and the promotion of insulin resistance, and subsequent pharmacological blockade shown to improve blood pressure, metabolic control and offer reno-protective effects. Abnormal adipocytokine levels including leptin and adiponectin may further promote the insulin resistant, and proinflammatory state in CKD. Ghrelin may be also implicated and controversial studies suggest activities may be reduced in human CKD, and may provide a rationale for administration of acyl-ghrelin. Poor vitamin D status has also been associated with patient outcome and CVD risk and may indicate a role for supplementation. Glucocorticoid activities traditionally known for their involvement in the pathogenesis of a number of disease states are increased and may be implicated in CKD-associated hypertension, insulin resistance, diabetes risk and cachexia, both directly and indirectly through effects on other systems including activation of the mineralcorticoid receptor. Insight into the multiple factors altered in CKD may provide useful information on disease pathogenesis, clinical assessment and treatment rationale such as potential pharmacological, nutritional and exercise therapies.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Slee ADdoi
10.1186/1743-7075-9-36subject
Has Abstractpub_date
2012-04-26 00:00:00pages
36issue
1issn
1743-7075pii
1743-7075-9-36journal_volume
9pub_type
杂志文章abstract:: This paper reviews evidence in the context of current research linking dietary fructose to health risk markers.Fructose intake has recently received considerable media attention, most of which has been negative. The assertion has been that dietary fructose is less satiating and more lipogenic than other sugars. Howev...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-82
更新日期:2010-11-04 00:00:00
abstract:BACKGROUND:Many publications link high homocysteine levels to cardiovascular disease. In Spain there is little information on the prevalence of hyperhomocysteinaemia and associated vitamin factors among the general population, and less still among children. Cardiovascular risk factors in the childhood population may be...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-39
更新日期:2009-10-05 00:00:00
abstract:BACKGROUND:Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. METH...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-71
更新日期:2011-10-15 00:00:00
abstract:UNLABELLED: BACKGROUND:It has been suggested that Sorghum, a rich source of phytochemicals, has a hypoglycemic effect, but the mechanism is unknown. We investigated the effects of oral administration of sorghum extract (SE) on hepatic gluconeogenesis and the glucose uptake of muscle in streptozotocin-induced diabetic ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-106
更新日期:2012-11-27 00:00:00
abstract::Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-13
更新日期:2014-03-19 00:00:00
abstract:Background:The evidence on the impact of high sugar consumption on micronutrient dilution does not yet allow for the establishment of clear thresholds of consumption. To establish upper and lower limit intake thresholds for added sugar, more studies from different countries and multiple populations are needed. The aim ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0428-6
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and steatohepatitis (NASH) result ultimately in fibrosis and cirrhosis, the molecular basis for lipid dropl...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-015-0012-7
更新日期:2015-05-20 00:00:00
abstract:BACKGROUND:The aim of the present study was to examine the effects of onion as functional ingredient on the oxidative status, lipoprotein levels (total cholesterol-TC, HDL-C, LDL-C), triacylglycerides (TAG) and vascular reactivity of mesenteric arteries in hypercholesterolemic Wistar rats. METHODS:Twenty-four animals ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-57
更新日期:2014-12-23 00:00:00
abstract::An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, P...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,评审
doi:10.1186/s12986-017-0233-z
更新日期:2017-12-22 00:00:00
abstract:BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-51
更新日期:2014-10-24 00:00:00
abstract:Background:Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type transition. In this study, we assessed the effects of natural flavonoid myricetin on exercise endur...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0353-8
更新日期:2019-05-02 00:00:00
abstract:Background:The aim of this study was to investigate how the signaling pathway downstream of mTOR/S6K1 contributes to the regulation of SREBP-1c expression during lipogenesis in HepG2 cells. Methods:The model of steatosis was established using human hepatocytes HepG2 and inducting them with sodium palmitate. mTOR, S6K1...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0268-9
更新日期:2018-05-02 00:00:00
abstract:: Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the reali...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-14
更新日期:2012-02-21 00:00:00
abstract:BACKGROUND:Elevated homocysteine is a cardiovascular risk factor in hyperlipidemia. Transsulfuration pathway provides an endogenous pathway for homocysteine conversion to antioxidant glutathione (GSH). Salvianolic acid A (Sal A) contains two molecules of caffeic acid and one molecule of danshensu that is capable of enh...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-10-68
更新日期:2013-12-06 00:00:00
abstract:BACKGROUND:Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is available regarding the role of microvesicles (MVs) derived from ATMs in macrophage-adipocyte crosstalk. ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-015-0016-3
更新日期:2015-06-06 00:00:00
abstract:BACKGROUND:Dietary n-3-polyunsaturated fatty acids (n-3-PUFA) have been shown to reduce body weight and fat mass in rodents as well as in humans in one small short-term study. We conducted this controlled randomized dietary trial to test the hypothesis that n-3-PUFA lower body weight and fat mass by reducing appetite a...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-24
更新日期:2009-05-29 00:00:00
abstract:Background:Muscle protein synthesis and muscle net balance plateau after moderate protein ingestion in adults. However, it has been suggested that there is no practical limit to the anabolic response of whole-body net balance to dietary protein. Moreover, limited research has addressed the anabolic response to dietary ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0301-z
更新日期:2018-09-24 00:00:00
abstract:Background:The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores. Methods:In this study, we enrolled 220 vegetarians and 220 o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00484-6
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:The protective effect of HDL is mostly attributed to their metabolic function in reverse cholesterol transport (RCT), a process whereby excess cellular cholesterol is taken up from peripheral cells, processed in HDL particles, and later delivered to the liver for further metabolism and biliary secretion. Mec...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-10-67
更新日期:2013-11-06 00:00:00
abstract:: Calorie restriction (CR; ~60% of ad libitum, AL intake) has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditional endocrine tissues, including skeletal muscle and other tissues, have been discovered to modulate energy m...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-90
更新日期:2012-10-15 00:00:00
abstract:BACKGROUND:Reducing dietary energy density has proven to be an effective strategy to reduce energy intakes and promote weight control. This effect appears most robust when a low energy dense preload is consumed before meals. Yet, much discussion continues regarding the optimal form of a preload. The purpose of the pres...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-8
更新日期:2011-02-02 00:00:00
abstract:Background:Visceral adipose tissue (VAT) area is a strong predictor of obesity-related cardiometabolic alterations, but its measurement is costly, time consuming and, in some cases, involves radiation exposure. Glutamate, a by-product of branched-chain-amino-acid (BCAA) catabolism, has been shown to be increased in vis...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0316-5
更新日期:2018-11-06 00:00:00
abstract:: Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially di...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-63
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-016-0103-0
更新日期:2016-06-29 00:00:00
abstract:BACKGROUND:Total body water (TBW) estimations have been used to estimate body composition, particularly fat-free mass, to aid in nutritional interventions, and to monitor hydration status. In the past, bioimpedance spectroscopy (BIS) devices have been used to estimate TBW. Previous investigations have examined the vali...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-5-7
更新日期:2008-03-19 00:00:00
abstract:BACKGROUND:The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS:In this case-control study, we included a total of 146 patients with DR and 148 without DR. The i...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-016-0099-5
更新日期:2016-06-04 00:00:00
abstract:BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-50
更新日期:2011-07-12 00:00:00
abstract:: A large volume of human clinical data supports increased dietary protein for favorable changes to body composition, but not all data are conclusive. The aim of this review is to propose two theories, "protein spread theory" and "protein change theory" in an effort to explain discrepancies in the literature. Protein s...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-81
更新日期:2012-09-12 00:00:00
abstract:BACKGROUND:Fasting is a rigorous type of dietary restriction that is associate with a number of health benefits. During fasting, ketone bodies significantly increase in blood and become major body fuels, thereby sparing glucose. In the present study, we investigated effects of fasting on hypersensitivity. In addition, ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-40
更新日期:2014-08-28 00:00:00
abstract:BACKGROUND:Increasing evidence suggests that diets high in polyunsaturated fatty acids (PUFA) confer health benefits by improving insulin sensitivity and lipid metabolism in liver, muscle and adipose tissue. METHODS:The present study investigates metabolic responses in two different lines of mice either selected for h...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-56
更新日期:2011-08-11 00:00:00