当前位置： SCI文献检索 > Nutrition & Metabolism期刊下所有文献 > Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study.

Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study.

Abstract：

BACKGROUND:Many publications link high homocysteine levels to cardiovascular disease. In Spain there is little information on the prevalence of hyperhomocysteinaemia and associated vitamin factors among the general population, and less still among children. Cardiovascular risk factors in the childhood population may be related to the appearance of cardiovascular disease at adult age. The aim of this study is to establish a definition of hyperhomocysteinaemia in adolescents and to analyze the influence of vitamin and metabolic factors in homocysteine levels in this population group. METHODS:Descriptive, cross-sectional epidemiological study to estimate serum homocysteine, vitamin B12 and folate levels, as well as plasma total, HDL- and LDL- cholesterol in a schoolgoing population aged 13 to 17 years in Madrid, Spain.Spearman correlation analysis was performed to ascertain quantitative comparison, Pearson's chi2 test (frequency < 5, Fisher) was used for comparison of prevalences, Mann-Whitney U and Kruskal-Wallis test were used for comparison of means and Bonferroni correction was used for post-hoc tests. A multivariate logistic regression model was performed in the multivariate analysis. RESULTS:Based on the classic values for definition of hyperhomocysteinaemia in adults, prevalence of hyperhomocysteinaemia in the study population was: 1.26% for 15 mumol/L; and 2.52% for 12 mumol/L.Deficits in HDL cholesterol and serum folate levels yielded adjusted Odds Ratios (OR) for hyperhomocysteinemia of 2.786, 95% CI (1.089-7.126), and 5.140, 95% CI (2.347-11.256) respectively. Mutation of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype also raises the risk of hyperhomocysteinaemia (CC-->CT: OR = 2.362; 95% CI (1.107-5.042) CC-->TT: OR = 6.124, 95% CI (2.301-16.303)) CONCLUSION:A good definition of hyperhomocysteinaemia in adolescents is the 90th percentile, equivalent to 8.23 mumol/L. Risk factors for hyperhomocysteinaemia are cHDL and folate deficiency, and the MTHFR C677T mutant genotype. No significant effect could be assessed for vitamin B12. Coexistence of all three factors increases the risk of suffering from hyperhomocysteinaemia 87-fold.

journal_name

Nutr Metab (Lond)

journal_title

Nutrition & metabolism

authors

Gil-Prieto R,Hernández V,Cano B,Oya M,Gil A

doi

10.1186/1743-7075-6-39

subject

Has Abstract

pub_date

2009-10-05 00:00:00

pages

issn

1743-7075

pii

1743-7075-6-39

journal_volume

pub_type

杂志文章

在线工具

Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study.