Long-term aerobic exercise and omega-3 supplementation modulate osteoporosis through inflammatory mechanisms in post-menopausal women: a randomized, repeated measures study.


BACKGROUND:Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. METHODS:Seventy-nine healthy sedentary post-menopausal women aged 58-78 years participated in this study. Subjects were randomized to one of 4 groups: exercise + supplement (E+S, n = 21), exercise (E, n = 20), supplement (S, n = 20), and control (Con, n = 18) groups. The subjects in the E+S and E groups performed aerobic exercise training (walking and jogging) up to 65% of HRmax, three times a week for 24 weeks. Subjects in the E+S and S groups consumed 1000 mg/d N-3 for 24 weeks. The lumbar spine (L2-L4) and femoral neck BMD, serum tumor necrosis factor (TNF) α, interleukin (IL) 6, prostaglandin (PG) E2, estrogen, osteocalcin, 1, 25-dihydroxyvitamin D3 (1, 25 Vit D), C-telopeptide (CTX), parathyroid hormone (PTH) and calcitonin (CT) were measured at baseline, the end of week 12 and 24. RESULTS:Serum estrogen, osteocalcin, 1, 25 Vit D, CT, L2-L4 and femoral neck BMD measures increased (P < 0.05) and the serum CTX, PTH, TNF-α, IL-6, and PGE2 decreased (P < 0.05) in E + S group after the 24 wk intervention but not in the E or S intervention groups. L2-L4 and femoral neck BMD, estrogen, osteocalcin, and CT were negatively (P < 0.05) correlated with TNF-α and PGE2. PTH and CT were correlated positively and negatively with IL-6, respectively (P < 0.05). CONCLUSIONS:The present study demonstrates that long-term aerobic exercise training plus N-3 supplementation have a synergistic effect in attenuating inflammation and augmenting BMD in post-menopausal osteoporosis.


Nutr Metab (Lond)


Nutrition & metabolism


Tartibian B,Hajizadeh Maleki B,Kanaley J,Sadeghi K




Has Abstract


2011-10-15 00:00:00










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    authors: Silver HJ,Dietrich MS,Niswender KD

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    authors: Orning L,Rian A,Campbell A,Brady J,Fedosov SN,Bramlage B,Thompson K,Quadros EV

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    pub_type: 杂志文章


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    更新日期:2014-12-23 00:00:00

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    journal_title:Nutrition & metabolism

    pub_type: 杂志文章


    authors: Main PA,Angley MT,O'Doherty CE,Thomas P,Fenech M

    更新日期:2012-04-24 00:00:00

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    journal_title:Nutrition & metabolism

    pub_type: 杂志文章


    authors: Zhang Y,Gu M,Wang R,Li M,Li D,Xie Z

    更新日期:2020-02-04 00:00:00

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    pub_type: 杂志文章


    authors: Chang J,Oikawa S,Ichihara G,Nanpei Y,Hotta Y,Yamada Y,Tada-Oikawa S,Iwahashi H,Kitagawa E,Takeuchi I,Yuda M,Ichihara S

    更新日期:2012-09-21 00:00:00

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    journal_title:Nutrition & metabolism

    pub_type: 杂志文章,评审


    authors: Akbari M,Ostadmohammadi V,Tabrizi R,Mobini M,Lankarani KB,Moosazadeh M,Heydari ST,Chamani M,Kolahdooz F,Asemi Z

    更新日期:2018-06-05 00:00:00

  • Metabolic programming of adipose tissue structure and function in male rat offspring by prenatal undernutrition.

    abstract:BACKGROUND:A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous ...

    journal_title:Nutrition & metabolism

    pub_type: 杂志文章


    authors: Thompson N,Huber K,Bedürftig M,Hansen K,Miles-Chan J,Breier BH

    更新日期:2014-10-18 00:00:00