Abstract:
BACKGROUND:Low plasma high-density lipoprotein-cholesterol (HDL-c) level is commonly present in obesity and represents an independent cardiovascular risk factor. However, obese patients are a very heterogeneous population and the factors and mechanisms that contribute to low HDL-c remain unclear. The aim of this study was to investigate the association between plasma HDL-c levels and plasma hormonal profiles (insulin, adiponectin, resistin, leptin and ghrelin) in subsets of class II and III obese patients. METHODS:Fasting plasma levels of glucose, total cholesterol, LDL-c, HDL-c, triglycerides, free fatty acids, apoproteins A-I, B-100, B-48, C-II, C-III, insulin, hs-CRP, adipocytokines (adiponectin, resistin, leptin), unacylated ghrelin, body composition (DXA) and resting energy expenditure were measured in three subsets of obese patients: 17 metabolically abnormal obese (MAO) with metabolic syndrome and the typical metabolic dyslipidaemia, 21 metabolically healthy obese (MHO) without metabolic syndrome and with a normal lipid profile, and 21 isolated low HDL-c obese patients (LHO) without metabolic syndrome, compared to 21 healthy lean control subjects. RESULTS:Insulin resistance (HOMA-IR) increased gradually from MHO to LHO and from LHO to MAO patients (p < 0.05 between MHO and MAO and between LHO and MAO). In multiple regression analysis, serum unacylated ghrelin levels were only positively and independently associated with HDL-c levels in the LHO group (p = 0.032). CONCLUSIONS:These results suggest that, in class II and III obese patients with an isolated low HDL-c phenotype, unacylated ghrelin is positively associated with HDL-c level independently of insulin resistance and CRP levels, and may contribute to the highly prevalent low HDL-c level seen in obesity.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Nogueira JP,Maraninchi M,Béliard S,Lorec AM,Berthet B,Bégu-Le Corroller A,Dubois N,Grangeot R,Mattei C,Gaudart J,Nicolay A,Portugal H,Vialettes B,Valéro Rdoi
10.1186/1743-7075-9-17subject
Has Abstractpub_date
2012-03-13 00:00:00pages
17issue
1issn
1743-7075pii
1743-7075-9-17journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Sub-optimally nourished rats show reduced growth, biochemical and physiological changes. However, no one has assessed metabolic rate adaptations in rats subjected to chronic suboptimal nutrition (CSN). In this study energy expenditure (EE; kcal/100 g body weight) and physical activity (PA; oscillations in we...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-3-11
更新日期:2006-01-31 00:00:00
abstract:PURPOSE:To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women. METHODS:Menstrual history, oral contraceptive use, exercise history, and nutritional factors including calcium, c...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-17
更新日期:2007-08-06 00:00:00
abstract:: This paper reviews evidence in the context of current research linking dietary fructose to health risk markers.Fructose intake has recently received considerable media attention, most of which has been negative. The assertion has been that dietary fructose is less satiating and more lipogenic than other sugars. Howev...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-82
更新日期:2010-11-04 00:00:00
abstract:Background:Visceral adipose tissue (VAT) area is a strong predictor of obesity-related cardiometabolic alterations, but its measurement is costly, time consuming and, in some cases, involves radiation exposure. Glutamate, a by-product of branched-chain-amino-acid (BCAA) catabolism, has been shown to be increased in vis...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0316-5
更新日期:2018-11-06 00:00:00
abstract:BACKGROUND:Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We re...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-33
更新日期:2010-04-22 00:00:00
abstract:BACKGROUND:Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This stu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-47
更新日期:2012-05-30 00:00:00
abstract::Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-13
更新日期:2014-03-19 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12986-018-0305-8.]. ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12986-018-0311-x
更新日期:2018-10-18 00:00:00
abstract:BACKGROUND:Compared to the corresponding source of inorganic trace minerals (TM), chelated supplements are characterized by better physical heterogeneity and chemical stability and appear to be better absorbed in the gut due to possibly decreased interaction with other feed components. METHODS:This study was designed ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00520-5
更新日期:2020-10-29 00:00:00
abstract:BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the di...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-44
更新日期:2014-09-15 00:00:00
abstract:Background:The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet indu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0249-z
更新日期:2018-02-17 00:00:00
abstract:Background:To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C and Ln TG/HDL-C, over an approximate 3 year duration, on incident type...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0287-6
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. METH...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-71
更新日期:2011-10-15 00:00:00
abstract:BACKGROUND:Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and steatohepatitis (NASH) result ultimately in fibrosis and cirrhosis, the molecular basis for lipid dropl...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-015-0012-7
更新日期:2015-05-20 00:00:00
abstract::Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of br...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-1
更新日期:2010-01-10 00:00:00
abstract:BACKGROUND:Total body water (TBW) estimations have been used to estimate body composition, particularly fat-free mass, to aid in nutritional interventions, and to monitor hydration status. In the past, bioimpedance spectroscopy (BIS) devices have been used to estimate TBW. Previous investigations have examined the vali...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-5-7
更新日期:2008-03-19 00:00:00
abstract:UNLABELLED: BACKGROUND:Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbe...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-109
更新日期:2012-12-05 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12986-016-0154-2.]. ...
journal_title:Nutrition & metabolism
pub_type: 已发布勘误
doi:10.1186/s12986-017-0192-4
更新日期:2017-06-14 00:00:00
abstract:BACKGROUND:A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-22
更新日期:2007-10-30 00:00:00
abstract:: Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,收录出版
doi:10.1186/1743-7075-5-27
更新日期:2008-10-18 00:00:00
abstract:BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-51
更新日期:2014-10-24 00:00:00
abstract::Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,评审
doi:10.1186/s12986-016-0109-7
更新日期:2016-08-08 00:00:00
abstract::Glucocorticoids are stress hormones that modulate a large number of physiological actions involved in metabolic, inflammatory, cardiovascular and behavioral processes. The molecular mechanisms and the physiological effects of glucocorticoids have been extensively studied. However, the involvement of glucocorticoid act...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-2-3
更新日期:2005-02-02 00:00:00
abstract:BACKGROUND:Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics. Several studies have indicated that children with autism spectrum disorders may have altered glutathione metabolism which could...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-35
更新日期:2012-04-24 00:00:00
abstract:Background:Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myocardial apo...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0432-x
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to alleviate the symptoms of metabolic disorders, such as heart disease, diabetes, obesity and insulin resistance. Several putative mechanisms by which n-3 PUFA elicit beneficial health effects have been proposed; however, there is still a shorta...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-6
更新日期:2014-01-17 00:00:00
abstract:Background:Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte beige cells, involved in so-called white adipocyte tissue (WAT) browning, has rec...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0373-4
更新日期:2019-07-16 00:00:00
abstract:: Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturb...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-36
更新日期:2012-04-26 00:00:00
abstract:BACKGROUND:Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-27
更新日期:2012-03-30 00:00:00
abstract:BACKGROUND:Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose,...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-32
更新日期:2014-07-04 00:00:00