当前位置： SCI文献检索 > Nutrition & Metabolism期刊下所有文献 > Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants.

Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants.

Abstract：

BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the dietary intakes that affect HDL-related measures: HDL-C, HDL-2, HDL-3, and apoA1 using data from a carotid artery disease case-control cohort. METHODS:A subset of 1,566 participants with extensive lipid phenotype data completed the Harvard Standardized Food Frequency Questionnaire to determine their daily micronutrient intake over the past year. Stepwise linear regression was used to separately evaluate the effects of dietary covariates on adjusted levels of HDL-C, HDL-2, HDL-3, and apoA1. RESULTS:Dietary folate intake was positively associated with HDL-C (p = 0.007), HDL-2 (p = 0.0011), HDL-3 (p = 0.0022), and apoA1 (p = 0.001). Alcohol intake and myristic acid (14:0), a saturated fat, were each significantly associated with increased levels of all HDL-related measures studied. Dietary carbohydrate and iron intake were significantly associated with decreased levels of all HDL-related measures. Magnesium intake was positively associated with HDL-C, HDL-2, and HDL-3 levels, but not apoA1 levels, while vitamin C was only associated with apoA1 levels. Dietary fiber and protein intake were both associated with HDL-3 levels alone. CONCLUSIONS:This study is the first to report that dietary folate intake is associated with HDL-C, HDL-2, HDL-3, and apoA1 levels in humans. We further identify numerous dietary intake associations with apoA1, HDL-2, and HDL-3 levels. Given the shifting focus away from HDL-C, these data will prove valuable for future epidemiologic investigation of the role of diet and multiple HDL phenotypes in heart disease.

journal_name

Nutr Metab (Lond)

journal_title

Nutrition & metabolism

authors

Kim DS,Burt AA,Ranchalis JE,Jarvik LE,Eintracht JF,Furlong CE,Jarvik GP

doi

10.1186/1743-7075-11-44

subject

Has Abstract

pub_date

2014-09-15 00:00:00

pages

issue

issn

1743-7075

pii

614

journal_volume

pub_type

杂志文章

在线工具

Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants.