Role of cytochrome P450 in drug interactions.

abstract：BACKGROUND:DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B12 and folate pathways are involved in the production of S-Adenosylmethionine, the universal methyl donor. FINDINGS:Brain vitamin B12 concentration and global DNA methylation was ...

journal_title：Nutrition & metabolism

authors： Fernàndez-Roig S,Lai SC,Murphy MM,Fernandez-Ballart J,Quadros EV

更新日期：2012-05-18 00:00:00

abstract：BACKGROUND:Endothelial dysfunction (ED) is an independent predictor of cardiovascular events. ED is also a reversible disorder, and nitric oxide donors like L-arginine may promote this process. Despite the positive results from several studies, there are some studies that have shown that L-arginine administration did n...

journal_title：Nutrition & metabolism

authors： Javanmard SH,Nematbakhsh M,Sanei MH

更新日期：2009-03-24 00:00:00

abstract：BACKGROUND:Dihydrocapsiate (DCT) is a natural safe food ingredient which is structurally related to capsaicin from chili pepper and is found in the non-pungent pepper strain, CH-19 Sweet. It has been shown to elicit the thermogenic effects of capsaicin but without its gastrointestinal side effects. METHODS:The present...

journal_title：Nutrition & metabolism

authors： Lee TA,Li Z,Zerlin A,Heber D

更新日期：2010-10-06 00:00:00

abstract：BACKGROUND:Dietary n-3-polyunsaturated fatty acids (n-3-PUFA) have been shown to reduce body weight and fat mass in rodents as well as in humans in one small short-term study. We conducted this controlled randomized dietary trial to test the hypothesis that n-3-PUFA lower body weight and fat mass by reducing appetite a...

journal_title：Nutrition & metabolism

authors： Kratz M,Callahan HS,Yang PY,Matthys CC,Weigle DS

更新日期：2009-05-29 00:00:00

abstract：BACKGROUND:Compared to the corresponding source of inorganic trace minerals (TM), chelated supplements are characterized by better physical heterogeneity and chemical stability and appear to be better absorbed in the gut due to possibly decreased interaction with other feed components. METHODS:This study was designed ...

journal_title：Nutrition & metabolism

authors： Ghasemi HA,Hajkhodadadi I,Hafizi M,Taherpour K,Nazaran MH

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:α-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion. PPHG is a major risk factor for diabetic vascular complications leading to disabilities and mortality in...

journal_title：Nutrition & metabolism

authors： Mohamed Sham Shihabudeen H,Hansi Priscilla D,Thirumurugan K

更新日期：2011-06-29 00:00:00

abstract：BACKGROUND:The protective effect of HDL is mostly attributed to their metabolic function in reverse cholesterol transport (RCT), a process whereby excess cellular cholesterol is taken up from peripheral cells, processed in HDL particles, and later delivered to the liver for further metabolism and biliary secretion. Mec...

journal_title：Nutrition & metabolism

authors： Lichtenstein L,Serhan N,Annema W,Combes G,Robaye B,Boeynaems JM,Perret B,Tietge UJF,Laffargue M,Martinez LO

更新日期：2013-11-06 00:00:00

abstract：BACKGROUND:Fasting is a rigorous type of dietary restriction that is associate with a number of health benefits. During fasting, ketone bodies significantly increase in blood and become major body fuels, thereby sparing glucose. In the present study, we investigated effects of fasting on hypersensitivity. In addition, ...

journal_title：Nutrition & metabolism

authors： Nakamura S,Hisamura R,Shimoda S,Shibuya I,Tsubota K

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to alleviate the symptoms of metabolic disorders, such as heart disease, diabetes, obesity and insulin resistance. Several putative mechanisms by which n-3 PUFA elicit beneficial health effects have been proposed; however, there is still a shorta...

journal_title：Nutrition & metabolism

authors： Ahmed AA,Balogun KA,Bykova NV,Cheema SK

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...

journal_title：Nutrition & metabolism

authors： Hosseini-Esfahani F,Bahadoran Z,Mirmiran P,Hosseinpour-Niazi S,Hosseinpanah F,Azizi F

更新日期：2011-07-12 00:00:00

abstract：: This paper reviews evidence in the context of current research linking dietary fructose to health risk markers.Fructose intake has recently received considerable media attention, most of which has been negative. The assertion has been that dietary fructose is less satiating and more lipogenic than other sugars. Howev...

journal_title：Nutrition & metabolism

authors： Rizkalla SW

更新日期：2010-11-04 00:00:00

abstract：:Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...

journal_title：Nutrition & metabolism

authors： Hussain MM,Abel L,Bakillah A

更新日期：2014-03-19 00:00:00

abstract：:OBJECTIVE: To compare the effects of isocaloric, energy-restricted very low-carbohydrate ketogenic (VLCK) and low-fat (LF) diets on weight loss, body composition, trunk fat mass, and resting energy expenditure (REE) in overweight/obese men and women. DESIGN: Randomized, balanced, two diet period clinical intervention ...

journal_title：Nutrition & metabolism

authors： Volek J,Sharman M,Gómez A,Judelson D,Rubin M,Watson G,Sokmen B,Silvestre R,French D,Kraemer W

更新日期：2004-11-08 00:00:00

abstract：BACKGROUND:Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant. Currently, no method allows simple, direct quantification of holotranscobalamin. We now report on the identificat...

journal_title：Nutrition & metabolism

authors： Orning L,Rian A,Campbell A,Brady J,Fedosov SN,Bramlage B,Thompson K,Quadros EV

更新日期：2006-01-04 00:00:00

abstract：BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects o...

journal_title：Nutrition & metabolism

authors： Bruckbauer A,Zemel MB

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. METH...

journal_title：Nutrition & metabolism

authors： Tartibian B,Hajizadeh Maleki B,Kanaley J,Sadeghi K

更新日期：2011-10-15 00:00:00

abstract：:Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of br...

journal_title：Nutrition & metabolism

authors： Moulton CJ,Valentine RJ,Layman DK,Devkota S,Singletary KW,Wallig MA,Donovan SM

更新日期：2010-01-10 00:00:00

abstract：: Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially di...

journal_title：Nutrition & metabolism

authors： Dornas WC,de Lima WG,Dos Santos RC,de Souza MO,Silva M,Diniz MF,Silva ME

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the di...

journal_title：Nutrition & metabolism

authors： Kim DS,Burt AA,Ranchalis JE,Jarvik LE,Eintracht JF,Furlong CE,Jarvik GP

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation of cytosolic mTORC1 to the lysosomal surface is required to stimulate mTORC1 kinase activity. Howeve...

journal_title：Nutrition & metabolism

authors： Graber TG,Borack MS,Reidy PT,Volpi E,Rasmussen BB

更新日期：2017-05-11 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that diets high in polyunsaturated fatty acids (PUFA) confer health benefits by improving insulin sensitivity and lipid metabolism in liver, muscle and adipose tissue. METHODS:The present study investigates metabolic responses in two different lines of mice either selected for h...

journal_title：Nutrition & metabolism

authors： Nuernberg K,Breier BH,Jayasinghe SN,Bergmann H,Thompson N,Nuernberg G,Dannenberger D,Schneider F,Renne U,Langhammer M,Huber K

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide...

journal_title：Nutrition & metabolism

authors： Gonzales AM,Orlando RA

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatitis (NASH). METHODS:We set up a prokaryotic expression system and purified the recombinant SFRP5 pro...

journal_title：Nutrition & metabolism

authors： Chen L,Zhao X,Liang G,Sun J,Lin Z,Hu R,Chen P,Zhang Z,Zhou L,Li Y

更新日期：2017-08-15 00:00:00

abstract：Background:The health benefits of dietary fibre (DF) intake on non-alcoholic fatty liver disease (NAFLD) are controversial. Thus, this large cross-sectional study aimed to determine the associations between DF intake and the prevalence of newly-diagnosed NAFLD in a large general population. Methods:A total of 23,529 p...

journal_title：Nutrition & metabolism

authors： Xia Y,Zhang S,Zhang Q,Liu L,Meng G,Wu H,Bao X,Gu Y,Sun S,Wang X,Zhou M,Jia Q,Song K,Wu Q,Niu K,Zhao Y

更新日期：2020-01-13 00:00:00

abstract：Background:It is not clear whether the frequently reported phenomenon of exercise-induced anorexia is exacerbated or blunted in warm or cold environments. Therefore, this study investigated the effects of exercise in three different environmental temperatures vs. rest, on perceptions of appetite, appetite regulating ho...

journal_title：Nutrition & metabolism

authors： Mandic I,Ahmed M,Rhind S,Goodman L,L'Abbe M,Jacobs I

更新日期：2019-05-06 00:00:00

abstract：UNLABELLED: BACKGROUND:It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in an animal model of the metabolic syndrome to identify the molecular targets associated...

journal_title：Nutrition & metabolism

authors： Chang J,Oikawa S,Ichihara G,Nanpei Y,Hotta Y,Yamada Y,Tada-Oikawa S,Iwahashi H,Kitagawa E,Takeuchi I,Yuda M,Ichihara S

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:As an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in redox-modulated calcium homeostasis and in protection against oxidative stress. METHODS:The effects of two diffe...

journal_title：Nutrition & metabolism

authors： Bodnár D,Ruzsnavszky O,Oláh T,Dienes B,Balatoni I,Ungvári É,Benkő I,Babka B,Prokisch J,Csernoch L,Szentesi P

更新日期：2016-11-03 00:00:00

abstract：:Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for ...

journal_title：Nutrition & metabolism

authors： Khan SA,Damanhouri G,Ali A,Khan SA,Khan A,Bakillah A,Marouf S,Al Harbi G,Halawani SH,Makki A

更新日期：2016-08-08 00:00:00

abstract：Background:We previously reported on the anti-obesogenic and anti-inflammatory effects associated with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in our diet-induced obesity (DIO) mouse model. Two isocaloric high-fat diets (HFDs; 48 kJ% fat), HFD (HF) and n-3 LCPUFA-enriched HFD (HF/n-3), and a control diet (C...

journal_title：Nutrition & metabolism

authors： Worsch S,Heikenwalder M,Hauner H,Bader BL

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:To study the effects of a pre-germinated brown rice diet (PR) on diabetic neuropathy in streptozotocin (STZ)-induced diabetic rats. METHODS:The effects of a PR diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with those fed brown rice (BR) or white rice (WR) diets with re...

journal_title：Nutrition & metabolism

authors： Usuki S,Ito Y,Morikawa K,Kise M,Ariga T,Rivner M,Yu RK

更新日期：2007-11-23 00:00:00