Abstract：
BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects of dairy diets on SIRT1 activation in two key target tissues (adipose and muscle tissue). METHODS:Serum from overweight and obese subjects fed low or high dairy diets for 28 days was added to culture medium (similar to conditioned media) to treat cultured adipocytes and muscle cells for 48 hours. RESULTS:Treatment with high dairy group conditioned media resulted in 40% increased SIRT1 gene expression in both tissues (p < 0.01) and 13% increased enzyme activity in adipose tissue compared to baseline. This was associated with increased gene expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF1), cytochrome oxidase c subunit 7 (Cox 7), NADH dehydrogenase and uncoupling protein 2 (UCP2) in adipocytes as well as uncoupling protein 3 (UCP3), NRF1 and Cox 7 in muscle cells (p < 0.05). Further, direct incubation of physiological concentrations of leucine and its metabolites α-Ketoisocaproic acid (KIC) and β-hydroxy-methylbuteric acid (HMB) with recombinant human SIRT1 enzyme resulted in 30 to 50% increase of SIRT1 activity (p < 0.05). CONCLUSIONS:These data indicate that dairy consumption leads to systemic effects, which may promote mitochondrial biogenesis in key target tissues such as muscle and adipose tissue both by direct activation of SIRT1 as well as by SIRT1-independent pathways.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Bruckbauer A,Zemel MBdoi
10.1186/1743-7075-8-91subject
Has Abstractpub_date
2011-12-20 00:00:00pages
91issn
1743-7075pii
1743-7075-8-91journal_volume
8pub_type
杂志文章abstract：OBJECTIVE:Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-63
更新日期：2011-09-19 00:00:00
abstract：BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0103-0
更新日期：2016-06-29 00:00:00
abstract：:Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
doi：10.1186/s12986-016-0109-7
更新日期：2016-08-08 00:00:00
abstract：BACKGROUND:Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics. Several studies have indicated that children with autism spectrum disorders may have altered glutathione metabolism which could...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-35
更新日期：2012-04-24 00:00:00
abstract：BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatitis (NASH). METHODS:We set up a prokaryotic expression system and purified the recombinant SFRP5 pro...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0208-0
更新日期：2017-08-15 00:00:00
abstract：Objective:We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace to reference measurement procedure. Materials and methods:From January 2018 to June 2019, a total of 4775 southern ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-0427-7
更新日期：2020-01-17 00:00:00
abstract：BACKGROUND:As an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in redox-modulated calcium homeostasis and in protection against oxidative stress. METHODS:The effects of two diffe...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0134-6
更新日期：2016-11-03 00:00:00
abstract：Background:Obesity has been identified as a major risk factor for a large number of chronic diseases. Understanding factors related to adolescent obesity is critical for prevention of chronic diseases. The associations between sleep duration and obesity among adolescents in the existing literature are controversial. Ou...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0285-8
更新日期：2018-07-09 00:00:00
abstract：:An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, P...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
doi：10.1186/s12986-017-0233-z
更新日期：2017-12-22 00:00:00
abstract：: Dietary ratios of omega-3 (n-3) to omega-6 (n-6) polyunsaturated fatty acids (PUFAs) have been implicated in controlling markers of the metabolic syndrome, including insulin sensitivity, inflammation, lipid profiles and adiposity. However, the role of dietary PUFAs in regulating energy systems in healthy relative to ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-53
更新日期：2010-06-28 00:00:00
abstract：BACKGROUND:Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored. The present study was to investigate the effects of hawthorn fruit extrac...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00535-y
更新日期：2021-01-07 00:00:00
abstract：BACKGROUND:Overweight and obesity are widespread chronic disorders defined as excessive fat accumulation, and are major risk factors for several chronic diseases including type 2 diabetes, coronary heart disease, high blood pressure and fatty liver. Changes in lifestyle such as increased physical activity and a healthy...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0151-5
更新日期：2016-12-06 00:00:00
abstract：UNLABELLED:Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity. However, weight loss interventions including dietary calcium or dairy product consumption have not reported changes in lipid metabolism measured by the plasma lipidome. METHODS:The objective of this stu...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-67
更新日期：2011-10-05 00:00:00
abstract：Background:NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives,...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0223-1
更新日期：2017-11-13 00:00:00
abstract：Background:Nut consumption has been shown to reduce the risk of cardiovascular disease. However, its role in the prevention of metabolic disorders, such as metabolic syndrome (Mets) and overweight/obesity, remains controversial. We therefore conducted a meta-analysis to determine the association of nut consumption with...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0282-y
更新日期：2018-06-22 00:00:00
abstract：BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-51
更新日期：2014-10-24 00:00:00
abstract：BACKGROUND:The aim of the present study was to examine the effects of onion as functional ingredient on the oxidative status, lipoprotein levels (total cholesterol-TC, HDL-C, LDL-C), triacylglycerides (TAG) and vascular reactivity of mesenteric arteries in hypercholesterolemic Wistar rats. METHODS:Twenty-four animals ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-57
更新日期：2014-12-23 00:00:00
abstract：Background:Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. Objective:To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Methods:Forty-five rats were divided randomly into three group...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0395-y
更新日期：2019-10-30 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is frequently associated with hypovitaminosis D. Vitamin D is endowed with pleiotropic effects, including insulin resistance (IR) and apoptotic pathway. Disruption of the complex mechanism that regulated ovarian apoptosis has been reported in PCOS. Phosphoprotein enriched in ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-84
更新日期：2011-11-23 00:00:00
abstract：Objective:This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders. Methods:We searched the following databases until N...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
doi：10.1186/s12986-018-0274-y
更新日期：2018-06-05 00:00:00
abstract：Background:We previously reported on the anti-obesogenic and anti-inflammatory effects associated with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in our diet-induced obesity (DIO) mouse model. Two isocaloric high-fat diets (HFDs; 48 kJ% fat), HFD (HF) and n-3 LCPUFA-enriched HFD (HF/n-3), and a control diet (C...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0291-x
更新日期：2018-09-26 00:00:00
abstract：BACKGROUND:Dihydrocapsiate (DCT) is a natural safe food ingredient which is structurally related to capsaicin from chili pepper and is found in the non-pungent pepper strain, CH-19 Sweet. It has been shown to elicit the thermogenic effects of capsaicin but without its gastrointestinal side effects. METHODS:The present...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-78
更新日期：2010-10-06 00:00:00
abstract：: Prior to the discovery of medical treatment for diabetes, carbohydrate-restriction was the predominant treatment recommendation to treat diabetes mellitus. In this commentary we argue that carbohydrate-restriction should be reincorporated into contemporary treatment studies for diabetes mellitus. ...
journal_title：Nutrition & metabolism
pub_type： 社论
doi：10.1186/1743-7075-5-10
更新日期：2008-04-09 00:00:00
abstract：BACKGROUND:Currently, there is a lack of studies examining the effects of adenosine-5'-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular ada...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-10-57
更新日期：2013-09-22 00:00:00
abstract：BACKGROUND:We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS). To find biomarkers of calcium deficiency and further confirm these biomarkers in serum, we p...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00507-2
更新日期：2020-11-23 00:00:00
abstract：BACKGROUND:A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-4-22
更新日期：2007-10-30 00:00:00
abstract：Background:Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte beige cells, involved in so-called white adipocyte tissue (WAT) browning, has rec...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0373-4
更新日期：2019-07-16 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12986-018-0305-8.]. ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12986-018-0311-x
更新日期：2018-10-18 00:00:00
abstract：:We studied the regulation of brain acetyl CoA carboxylase (ACC) activity during food deprivation and under the influence of hormones of glucose homeostasis: glucagon and insulin. Mice were deprived of food and water for time periods of 1, 3, 6, 9, 12 and 24 hours and were then allowed to re-feed for 5, 30 and 60 minut...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-3-15
更新日期：2006-02-16 00:00:00
abstract：UNLABELLED: BACKGROUND:Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbe...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-109
更新日期：2012-12-05 00:00:00
