Abstract:
BACKGROUND:Overweight and obesity are widespread chronic disorders defined as excessive fat accumulation, and are major risk factors for several chronic diseases including type 2 diabetes, coronary heart disease, high blood pressure and fatty liver. Changes in lifestyle such as increased physical activity and a healthy diet can be crucial tools for treating obesity. Intake of rose hip, the fruit of several plants belonging to the Rosaceae family, has been shown to reduce body fat mass and prevent body weight gain. Thus, the aim of the study was to elucidate potential mechanisms through which rose hip inhibit diet-induced obesity. METHODS:C57BL/6 J mice were fed a high fat diet with (RH) or without (CTR) rose hip supplementation for three months. In vivo indirect calorimetry was monitored, as well as gene expression and protein levels of different adipose depots. RESULTS:Although no differences in energy intake were found compared to the CTR group, RH prevented body weight gain and lowered blood glucose, insulin and cholesterol levels. Indirect calorimetry showed that RH-fed mice have significantly higher EE during the dark phase, despite comparable voluntary activity. Moreover, when challenged with treadmill running, RH-fed mice exhibited higher metabolic rate. Therefore, we hypothesized that RH could stimulate the brown adipose tissue (BAT) thermogenic capacity or may induce browning of the white adipose tissue (WAT). Compared to the CTR group, gene expression and protein levels of some brown and "brite" markers, together with genes able to promote brown adipocyte differentiation and thermogenesis (such as ucp1, tbx15, bmp7, and cidea), as well as phosphorylation of AMPK, was increased in WAT (but not in BAT) of RH-fed mice. CONCLUSIONS:Taken together these results indicate that dietary rose hip prevents body weight gain by increasing whole body EE and inducing browning of WAT. Thus, it has potential therapeutic implication for treatment of obesity and related metabolic disorders.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Cavalera M,Axling U,Berger K,Holm Cdoi
10.1186/s12986-016-0151-5subject
Has Abstractpub_date
2016-12-06 00:00:00pages
91issn
1743-7075pii
151journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-91
更新日期:2011-12-20 00:00:00
abstract:: Liver steatosis is a frequent histological feature in patients chronically infected with hepatitis C virus (HCV). The relationship between HCV and hepatic steatosis seems to be the result of both epigenetic and genetic factors. In vivo and in vitro studies have shown that HCV can alter intrahepatic lipid metabolism b...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-13
更新日期:2010-02-23 00:00:00
abstract:Background:Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type transition. In this study, we assessed the effects of natural flavonoid myricetin on exercise endur...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0353-8
更新日期:2019-05-02 00:00:00
abstract:Background:To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C and Ln TG/HDL-C, over an approximate 3 year duration, on incident type...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0287-6
更新日期:2018-07-11 00:00:00
abstract:BACKGROUND:Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We re...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-33
更新日期:2010-04-22 00:00:00
abstract:Background:Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. W...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0398-8
更新日期:2019-10-16 00:00:00
abstract:BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-016-0103-0
更新日期:2016-06-29 00:00:00
abstract:Background:Diet and exercise play important roles in ameliorating metabolic syndrome. Yunkang 10 (Camellia sinensis var. assamica) is a most cultivated tea variety for making tea in the Southwestern China. Currently, there is no report of healthy effects of Yunkang 10 green tea (YKGT) and treadmill exercise (Ex) on hig...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0433-9
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:Currently, there is a lack of studies examining the effects of adenosine-5'-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular ada...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-10-57
更新日期:2013-09-22 00:00:00
abstract:: Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturb...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-36
更新日期:2012-04-26 00:00:00
abstract:BACKGROUND:Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids (PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies that measured blood levels of n-3 and n-6 PUFAs. We examined the association between blood levels of PUFAs and homocysteine in Japane...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-10-41
更新日期:2013-06-10 00:00:00
abstract:Background:The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores. Methods:In this study, we enrolled 220 vegetarians and 220 o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00484-6
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:Dietary n-3-polyunsaturated fatty acids (n-3-PUFA) have been shown to reduce body weight and fat mass in rodents as well as in humans in one small short-term study. We conducted this controlled randomized dietary trial to test the hypothesis that n-3-PUFA lower body weight and fat mass by reducing appetite a...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-6-24
更新日期:2009-05-29 00:00:00
abstract:: Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,收录出版
doi:10.1186/1743-7075-5-27
更新日期:2008-10-18 00:00:00
abstract:BACKGROUND:Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose,...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-32
更新日期:2014-07-04 00:00:00
abstract:Background:Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myocardial apo...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0432-x
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the di...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-44
更新日期:2014-09-15 00:00:00
abstract:Background:Consumption of diet high in soy products is suggested to contribute to lower prostate cancer incidence in Asian men. But little has been known about the influences of dietary patterns on gut microbiota and microbiota-mediated isoflavone metabolism. Here, we determined the influences of western pattern diet o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0351-x
更新日期:2019-04-11 00:00:00
abstract:Background:Obesity has been identified as a major risk factor for a large number of chronic diseases. Understanding factors related to adolescent obesity is critical for prevention of chronic diseases. The associations between sleep duration and obesity among adolescents in the existing literature are controversial. Ou...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0285-8
更新日期:2018-07-09 00:00:00
abstract:PURPOSE:To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women. METHODS:Menstrual history, oral contraceptive use, exercise history, and nutritional factors including calcium, c...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-4-17
更新日期:2007-08-06 00:00:00
abstract::Breast cancer is the most prevalent cancer in American women. Dietary factors are thought to have a strong influence on breast cancer incidence. This study utilized a meal-feeding protocol with female Sprague-Dawley rats to evaluate effects of two ratios of carbohydrate:protein on promotion and early progression of br...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-1
更新日期:2010-01-10 00:00:00
abstract::Although feeding deficits have been reported in snakes and lizards following vomeronasal system disruption, no deficit has been previously reported in a mammal. We tested gray short-tailed opossums with items from four different food categories prior to occluding access to the vomeronasal organ. Preoperatively, opossu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-2-6
更新日期:2005-02-22 00:00:00
abstract::There has been intense interest in defining the functions of UCP2 and UCP3 during the nine years since the cloning of these UCP1 homologues. Current data suggest that both UCP2 and UCP3 proteins share some features with UCP1, such as the ability to reduce mitochondrial membrane potential, but they also have distinctly...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-3-38
更新日期:2006-09-12 00:00:00
abstract:BACKGROUND:Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-27
更新日期:2012-03-30 00:00:00
abstract:BACKGROUND:Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatitis (NASH). METHODS:We set up a prokaryotic expression system and purified the recombinant SFRP5 pro...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0208-0
更新日期:2017-08-15 00:00:00
abstract:Background:We previously reported on the anti-obesogenic and anti-inflammatory effects associated with n-3 long-chain polyunsaturated fatty acids (LCPUFA) in our diet-induced obesity (DIO) mouse model. Two isocaloric high-fat diets (HFDs; 48 kJ% fat), HFD (HF) and n-3 LCPUFA-enriched HFD (HF/n-3), and a control diet (C...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0291-x
更新日期:2018-09-26 00:00:00
abstract:Background:The aim of this study was to investigate how the signaling pathway downstream of mTOR/S6K1 contributes to the regulation of SREBP-1c expression during lipogenesis in HepG2 cells. Methods:The model of steatosis was established using human hepatocytes HepG2 and inducting them with sodium palmitate. mTOR, S6K1...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0268-9
更新日期:2018-05-02 00:00:00
abstract:UNLABELLED: BACKGROUND:Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbe...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-109
更新日期:2012-12-05 00:00:00
abstract:BACKGROUND:Adipocyte volume (fat accumulation) and cell number (adipogenesis) is increased in obese individuals. Our objective was the identification of dietary constituents with inhibitory effects on triglyceride formation during adipogenesis. Therefore an in vitro adipose cell assay in murine C3H10 T1/2 cells was dev...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-30
更新日期:2011-05-12 00:00:00
abstract::We studied the regulation of brain acetyl CoA carboxylase (ACC) activity during food deprivation and under the influence of hormones of glucose homeostasis: glucagon and insulin. Mice were deprived of food and water for time periods of 1, 3, 6, 9, 12 and 24 hours and were then allowed to re-feed for 5, 30 and 60 minut...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-3-15
更新日期:2006-02-16 00:00:00