Abstract:
BACKGROUND:The aim of this study was to evaluate the relationship between intakes of energy-providing macronutrients, and markers of cardio metabolic risk factors in high BMI African American (AA) children. METHODS:A cross sectional analysis of a sample of 9-11 year old children (n = 80) with BMI greater then the 85th percentile. Fasting hematological and biochemical measurements, and blood pressure were measured as selected markers of cardio metabolic risk factors and their relationships to dietary intakes determined. RESULTS:After adjusting for gender, pubertal stage and waist circumference (WC), multivariate regression analysis showed that higher total energy intakes (when unadjusted for source of energy) were associated with higher plasma concentrations of intermediate density lipoprotein cholesterol (IDL-C) and very low density lipoprotein cholesterol (VLDL-C). Higher intakes of carbohydrate energy (fat and protein held constant) were associated with higher IDL-C, VLDL-C, triglycerides (TG) and homeostasis model assessment of insulin resistance (HOMA-IR). Higher intakes of fat (carbohydrate and protein held constant), however, were associated with lower IDL-C; and higher protein intakes (fat and carbohydrate held constant) were associated with lower HOMA-IR. CONCLUSION:The specific macronutrients that contribute energy are significantly associated with a wide range of cardio metabolic risk factors in high BMI AA children. Increases in carbohydrate energy were associated with undesirable effects including increases in several classes of plasma lipids and HOMA-IR. Increases in protein energy were associated with the desirable effect of reduced HOMA-IR, and fat energy intakes were associated with the desirable effect of reduced IDL-C. This analysis suggests that the effect of increased energy on risk of developing cardio metabolic risk factors is influenced by the source of that energy.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Sharma S,Roberts LS,Hudes ML,Lustig RH,Fleming SEdoi
10.1186/1743-7075-6-41subject
Has Abstractpub_date
2009-10-13 00:00:00pages
41issn
1743-7075pii
1743-7075-6-41journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Management of glioblastoma multiforme (GBM) has been difficult using standard therapy (radiation with temozolomide chemotherapy). The ketogenic diet is used commonly to treat refractory epilepsy in children and, when administered in restricted amounts, can also target energy metabolism in brain tumors. We re...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-33
更新日期:2010-04-22 00:00:00
abstract:OBJECTIVE:Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-63
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-57
更新日期:2014-12-23 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0187-1
更新日期:2017-05-11 00:00:00
abstract:BACKGROUND:From a health promotion perspective, the use of dietary indices is preferred above single nutrients and foods to evaluate diet quality. Longitudinal research about the association between dietary indices and respectively anthropometric parameters and blood lipids is lacking. The aim of this study was to inve...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-015-0042-1
更新日期:2015-11-19 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0373-4
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-016-0103-0
更新日期:2016-06-29 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-00535-y
更新日期:2021-01-07 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-40
更新日期:2014-08-28 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-82
更新日期:2010-11-04 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0285-8
更新日期:2018-07-09 00:00:00
abstract:BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-8-50
更新日期:2011-07-12 00:00:00
abstract:Background:The health benefits of dietary fibre (DF) intake on non-alcoholic fatty liver disease (NAFLD) are controversial. Thus, this large cross-sectional study aimed to determine the associations between DF intake and the prevalence of newly-diagnosed NAFLD in a large general population. Methods:A total of 23,529 p...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0420-1
更新日期:2020-01-13 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-8
更新日期:2010-01-29 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-019-0398-8
更新日期:2019-10-16 00:00:00
abstract:: Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,收录出版
doi:10.1186/1743-7075-5-27
更新日期:2008-10-18 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12986-016-0154-2.]. ...
journal_title:Nutrition & metabolism
pub_type: 已发布勘误
doi:10.1186/s12986-017-0192-4
更新日期:2017-06-14 00:00:00
abstract:Background:Muscle protein synthesis and muscle net balance plateau after moderate protein ingestion in adults. However, it has been suggested that there is no practical limit to the anabolic response of whole-body net balance to dietary protein. Moreover, limited research has addressed the anabolic response to dietary ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0301-z
更新日期:2018-09-24 00:00:00
abstract:BACKGROUND:A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous ...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-11-50
更新日期:2014-10-18 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-5-7
更新日期:2008-03-19 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0427-7
更新日期:2020-01-17 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-41
更新日期:2012-05-18 00:00:00
abstract:: A large volume of human clinical data supports increased dietary protein for favorable changes to body composition, but not all data are conclusive. The aim of this review is to propose two theories, "protein spread theory" and "protein change theory" in an effort to explain discrepancies in the literature. Protein s...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-81
更新日期:2012-09-12 00:00:00
abstract:Background:The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet indu...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-018-0249-z
更新日期:2018-02-17 00:00:00
abstract:BACKGROUND:The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio and IR in the Chinese population. Here, we aimed to explore whether the ALT/AST ratio is associated an...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-017-0219-x
更新日期:2017-10-10 00:00:00
abstract:Objective:This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders. Methods:We searched the following databases until N...
journal_title:Nutrition & metabolism
pub_type: 杂志文章,评审
doi:10.1186/s12986-018-0274-y
更新日期:2018-06-05 00:00:00
abstract:BACKGROUND:Dihydrocapsiate (DCT) is a natural safe food ingredient which is structurally related to capsaicin from chili pepper and is found in the non-pungent pepper strain, CH-19 Sweet. It has been shown to elicit the thermogenic effects of capsaicin but without its gastrointestinal side effects. METHODS:The present...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-7-78
更新日期:2010-10-06 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-015-0016-3
更新日期:2015-06-06 00:00:00
abstract:BACKGROUND:Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fa...
journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/1743-7075-9-27
更新日期:2012-03-30 00:00:00
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journal_title:Nutrition & metabolism
pub_type: 杂志文章
doi:10.1186/s12986-020-0428-6
更新日期:2020-02-11 00:00:00