Abstract：
Background:The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet induced severe body weight (BW) loss. Method:From 20 obese patients who lost 20.2 kg of BW after a 4-months VLCK-diet, blood samples and body composition analysis, determined by DXA and MF-Bioimpedance, and RMR by indirect calorimetry, were obtained on four subsequent visits: visit C-1, basal, initial fat mass (FM) and free fat mass (FFM); visit C-2, - 7.2 kg in FM, - 4.3 kg in FFM, maximal ketosis; visit C-3, - 14.4 kg FM, - 4.5 kg FFM, low ketosis; visit C-4, - 16.5 kg FM, - 3.8 kg FFM, no ketosis. Each subject acted as his own control. Results:Despite the large BW reduction, measured RMR varied from basal visit C-1 to visit C-2, - 1.0%; visit C-3, - 2.4% and visit C-4, - 8.0%, without statistical significance. No metabolic adaptation was observed. The absent reduction in RMR was not due to increased sympathetic tone, as thyroid hormones, catecholamines, and leptin were reduced at any visit from baseline. Under regression analysis FFM, adjusted by levels of ketonic bodies, was the only predictor of the RMR changes (R2 = 0.36; p < 0.001). Conclusion:The rapid and sustained weight and FM loss induced by VLCK-diet in obese subjects did not induce the expected reduction in RMR, probably due to the preservation of lean mass. Trial registration:This is a follow up study on a published clinical trial.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Gomez-Arbelaez D,Crujeiras AB,Castro AI,Martinez-Olmos MA,Canton A,Ordoñez-Mayan L,Sajoux I,Galban C,Bellido D,Casanueva FFdoi
10.1186/s12986-018-0249-zsubject
Has Abstractpub_date
2018-02-17 00:00:00pages
18issn
1743-7075pii
249journal_volume
15pub_type
杂志文章abstract：BACKGROUND:Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. METH...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-71
更新日期：2011-10-15 00:00:00
abstract：BACKGROUND:The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS:In this case-control study, we included a total of 146 patients with DR and 148 without DR. The i...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0099-5
更新日期：2016-06-04 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-6-24
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0151-5
更新日期：2016-12-06 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-10-68
更新日期：2013-12-06 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-63
更新日期：2012-06-27 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-1-13
更新日期：2004-11-08 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0373-4
更新日期：2019-07-16 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0356-5
更新日期：2019-05-28 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章,收录出版
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更新日期：2008-10-18 00:00:00
abstract：Background:Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. W...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0398-8
更新日期：2019-10-16 00:00:00
abstract：: Liver steatosis is a frequent histological feature in patients chronically infected with hepatitis C virus (HCV). The relationship between HCV and hepatic steatosis seems to be the result of both epigenetic and genetic factors. In vivo and in vitro studies have shown that HCV can alter intrahepatic lipid metabolism b...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-13
更新日期：2010-02-23 00:00:00
abstract：Background:To investigate the association between different obesity phenotypes and the risk of incident hypertension among both genders. Methods:The study population included 3659 Iranians (men = 1540), aged ≥20 years free of hypertension at baseline. Participants were classified into six categories of body mass index...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0340-0
更新日期：2019-02-27 00:00:00
abstract：Objective:This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders. Methods:We searched the following databases until N...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
doi：10.1186/s12986-018-0274-y
更新日期：2018-06-05 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate whether two variants of the TCF7L2 (rs7903146 and rs12255372) modify the association between nut consumption and the risk of metabolic syndrome (MetS). Additionally, the modifying effect of weight change during follow-up on these associations was investigated. MATERI...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-021-00542-7
更新日期：2021-01-12 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-36
更新日期：2012-04-26 00:00:00
abstract：Background:Muscle protein synthesis and muscle net balance plateau after moderate protein ingestion in adults. However, it has been suggested that there is no practical limit to the anabolic response of whole-body net balance to dietary protein. Moreover, limited research has addressed the anabolic response to dietary ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0301-z
更新日期：2018-09-24 00:00:00
abstract：Background:Visceral adipose tissue (VAT) area is a strong predictor of obesity-related cardiometabolic alterations, but its measurement is costly, time consuming and, in some cases, involves radiation exposure. Glutamate, a by-product of branched-chain-amino-acid (BCAA) catabolism, has been shown to be increased in vis...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0316-5
更新日期：2018-11-06 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-41
更新日期：2012-05-18 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0282-y
更新日期：2018-06-22 00:00:00
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pub_type： 杂志文章
doi：10.1186/s12986-018-0268-9
更新日期：2018-05-02 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0420-1
更新日期：2020-01-13 00:00:00
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journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0351-x
更新日期：2019-04-11 00:00:00
abstract：Background:NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives,...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0223-1
更新日期：2017-11-13 00:00:00
abstract：BACKGROUND:We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE). METHODS:Following 10-15% weight loss, 21 overweight subjects consumed 3 weight-loss maintenance diets [low fat (LF), low glycem...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0198-y
更新日期：2017-07-05 00:00:00
abstract：:Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-13
更新日期：2014-03-19 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12986-018-0305-8.]. ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12986-018-0311-x
更新日期：2018-10-18 00:00:00
abstract：OBJECTIVE:Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-63
更新日期：2011-09-19 00:00:00
abstract：BACKGROUND:To study the effects of a pre-germinated brown rice diet (PR) on diabetic neuropathy in streptozotocin (STZ)-induced diabetic rats. METHODS:The effects of a PR diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with those fed brown rice (BR) or white rice (WR) diets with re...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-4-25
更新日期：2007-11-23 00:00:00
abstract：Background:To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C and Ln TG/HDL-C, over an approximate 3 year duration, on incident type...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0287-6
更新日期：2018-07-11 00:00:00
