当前位置： SCI文献检索 > Nutrition & Metabolism期刊下所有文献 > High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression.

High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression.

Abstract：

Background:High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development of heart failure and diabetic cardiomyopathy. High-density lipoprotein (HDL) has been reported to possess key atheroprotective biological properties, including cellular cholesterol efflux capacity, anti-oxidative and anti-inflammatory activities. However, the underlying mechanisms are still largely unknown. Therefore, the aim of the present study is to test whether HDL could protect palmitic acid (PA)-induced cardiomyocyte injury and explore the possible mechanisms. Results:H9c2 cells were pretreated with HDL (50-100 μg/ml) for 2 h followed by PA (0.5 mM) for indicated time period. Our results showed that HDL inhibited PA-induced cell death in a dose-dependent manner. Moreover, HDL rescued PA-induced ROS generation and the phosphorylation of JNK which in turn activated NF-κB-mediated inflammatory proteins expressions. We also found that PA impaired the balance of BCL2 family proteins, destabilized mitochondrial membrane potential, and triggered subsequent cytochrome c release into the cytosol and activation of caspase 3. These detrimental effects were ameliorated by HDL treatment. Conclusion:PA-induced ROS accumulation and results in cardiomyocyte apoptosis and inflammation. However, HDL attenuated PA-induced lipotoxicity and oxidative dysfunction via ROS suppression. These results may provide insight into a possible molecular mechanism underlying HDL suppression of the free fatty acid-induced cardiomyocyte apoptosis.

journal_name

Nutr Metab (Lond)

journal_title

Nutrition & metabolism

authors

Wu KM,Hsu YM,Ying MC,Tsai FJ,Tsai CH,Chung JG,Yang JS,Tang CH,Cheng LY,Su PH,Viswanadha VP,Kuo WW,Huang CY

doi

10.1186/s12986-019-0356-5

subject

Has Abstract

pub_date

2019-05-28 00:00:00

pages

36

issn

1743-7075

pii

356

journal_volume

16

pub_type

杂志文章

相关文献

Nutrition & Metabolism文献大全
  • Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory.

    abstract：BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-016-0103-0

    authors： Yonamine CY,Pinheiro-Machado E,Michalani ML,Freitas HS,Okamoto MM,Corrêa-Giannella ML,Machado UF

    更新日期：2016-06-29 00:00:00

  • Exploring metabolic dysfunction in chronic kidney disease.

    abstract：: Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturb...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-9-36

    authors： Slee AD

    更新日期：2012-04-26 00:00:00

  • Effects of oral adenosine-5'-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men.

    abstract：BACKGROUND:Currently, there is a lack of studies examining the effects of adenosine-5'-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular ada...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-10-57

    authors： Wilson JM,Joy JM,Lowery RP,Roberts MD,Lockwood CM,Manninen AH,Fuller JC,De Souza EO,Baier SM,Wilson SM,Rathmacher JA

    更新日期：2013-09-22 00:00:00

  • A low alpha-linolenic intake during early life increases adiposity in the adult guinea pig.

    abstract：BACKGROUND:The composition of dietary fatty acids (FA) during early life may impact adult adipose tissue (AT) development. We investigated the effects of alpha-linolenic acid (ALA) intake during the suckling/weaning period on AT development and metabolic markers in the guinea pig (GP). METHODS:Newborn GP were fed a 27...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-7-8

    authors： Pouteau E,Aprikian O,Grenot C,Reynaud D,Pace-Asciak C,Cuilleron CY,Castañeda-Gutiérrez E,Moulin J,Pescia G,Beysen C,Turner S,Macé K

    更新日期：2010-01-29 00:00:00

  • Activation of transsulfuration pathway by salvianolic acid a treatment: a homocysteine-lowering approach with beneficial effects on redox homeostasis in high-fat diet-induced hyperlipidemic rats.

    abstract：BACKGROUND:Elevated homocysteine is a cardiovascular risk factor in hyperlipidemia. Transsulfuration pathway provides an endogenous pathway for homocysteine conversion to antioxidant glutathione (GSH). Salvianolic acid A (Sal A) contains two molecules of caffeic acid and one molecule of danshensu that is capable of enh...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-10-68

    authors： Zhang W,He H,Wang H,Wang S,Li X,Liu Y,Jiang H,Jiang H,Yan Y,Wang Y,Liu X

    更新日期：2013-12-06 00:00:00

  • Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial.

    abstract：BACKGROUND:Dihydrocapsiate (DCT) is a natural safe food ingredient which is structurally related to capsaicin from chili pepper and is found in the non-pungent pepper strain, CH-19 Sweet. It has been shown to elicit the thermogenic effects of capsaicin but without its gastrointestinal side effects. METHODS:The present...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-7-78

    authors： Lee TA,Li Z,Zerlin A,Heber D

    更新日期：2010-10-06 00:00:00

  • Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation.

    abstract：BACKGROUND:Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored. The present study was to investigate the effects of hawthorn fruit extrac...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-020-00535-y

    authors： He Z,Kwek E,Hao W,Zhu H,Liu J,Ma KY,Chen ZY

    更新日期：2021-01-07 00:00:00

  • Has carbohydrate-restriction been forgotten as a treatment for diabetes mellitus? A perspective on the ACCORD study design.

    abstract：: Prior to the discovery of medical treatment for diabetes, carbohydrate-restriction was the predominant treatment recommendation to treat diabetes mellitus. In this commentary we argue that carbohydrate-restriction should be reincorporated into contemporary treatment studies for diabetes mellitus. ...

    journal_title：Nutrition & metabolism

    pub_type： 社论

    doi：10.1186/1743-7075-5-10

    authors： Westman EC,Vernon MC

    更新日期：2008-04-09 00:00:00

  • Impact of 3-year changes in lipid parameters and their ratios on incident type 2 diabetes: Tehran lipid and glucose study.

    abstract：Background:To examine the impact of changes in all lipid measures including total cholesterol (TC), log-transformed triglycerides (Ln-TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C and Ln TG/HDL-C, over an approximate 3 year duration, on incident type...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-018-0287-6

    authors： Khaloo P,Hasheminia M,Tohidi M,Abdi H,Mansournia MA,Azizi F,Hadaegh F

    更新日期：2018-07-11 00:00:00

  • Role of cytochrome P450 in drug interactions.

    abstract：: Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepa...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章,收录出版

    doi：10.1186/1743-7075-5-27

    authors： Bibi Z

    更新日期：2008-10-18 00:00:00

  • Dietary protein in weight management: a review proposing protein spread and change theories.

    abstract：: A large volume of human clinical data supports increased dietary protein for favorable changes to body composition, but not all data are conclusive. The aim of this review is to propose two theories, "protein spread theory" and "protein change theory" in an effort to explain discrepancies in the literature. Protein s...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-9-81

    authors： Bosse JD,Dixon BM

    更新日期：2012-09-12 00:00:00

  • Multiple functions of microsomal triglyceride transfer protein.

    abstract：: Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the reali...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-9-14

    authors： Hussain MM,Rava P,Walsh M,Rana M,Iqbal J

    更新日期：2012-02-21 00:00:00

  • Protein energy malnutrition increases arginase activity in monocytes and macrophages.

    abstract：BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-11-51

    authors： Corware K,Yardley V,Mack C,Schuster S,Al-Hassi H,Herath S,Bergin P,Modolell M,Munder M,Müller I,Kropf P

    更新日期：2014-10-24 00:00:00

  • Health implications of fructose consumption: A review of recent data.

    abstract：: This paper reviews evidence in the context of current research linking dietary fructose to health risk markers.Fructose intake has recently received considerable media attention, most of which has been negative. The assertion has been that dietary fructose is less satiating and more lipogenic than other sugars. Howev...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-7-82

    authors： Rizkalla SW

    更新日期：2010-11-04 00:00:00

  • LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells.

    abstract：Background:The aim of this study was to investigate how the signaling pathway downstream of mTOR/S6K1 contributes to the regulation of SREBP-1c expression during lipogenesis in HepG2 cells. Methods:The model of steatosis was established using human hepatocytes HepG2 and inducting them with sodium palmitate. mTOR, S6K1...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-018-0268-9

    authors： Zhou Y,Yu S,Cai C,Zhong L,Yu H,Shen W

    更新日期：2018-05-02 00:00:00

  • E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish.

    abstract：BACKGROUND:Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and steatohepatitis (NASH) result ultimately in fibrosis and cirrhosis, the molecular basis for lipid dropl...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-015-0012-7

    authors： Shimada Y,Kuninaga S,Ariyoshi M,Zhang B,Shiina Y,Takahashi Y,Umemoto N,Nishimura Y,Enari H,Tanaka T

    更新日期：2015-05-20 00:00:00

  • Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.

    abstract：BACKGROUND:Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation of cytosolic mTORC1 to the lysosomal surface is required to stimulate mTORC1 kinase activity. Howeve...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-017-0187-1

    authors： Graber TG,Borack MS,Reidy PT,Volpi E,Rasmussen BB

    更新日期：2017-05-11 00:00:00

  • Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499.

    abstract：Background:Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type transition. In this study, we assessed the effects of natural flavonoid myricetin on exercise endur...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-019-0353-8

    authors： Wu L,Ran L,Lang H,Zhou M,Yu L,Yi L,Zhu J,Liu L,Mi M

    更新日期：2019-05-02 00:00:00

  • Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells.

    abstract：BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects o...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-8-91

    authors： Bruckbauer A,Zemel MB

    更新日期：2011-12-20 00:00:00

  • Dietary n-3-polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial.

    abstract：BACKGROUND:Dietary n-3-polyunsaturated fatty acids (n-3-PUFA) have been shown to reduce body weight and fat mass in rodents as well as in humans in one small short-term study. We conducted this controlled randomized dietary trial to test the hypothesis that n-3-PUFA lower body weight and fat mass by reducing appetite a...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-6-24

    authors： Kratz M,Callahan HS,Yang PY,Matthys CC,Weigle DS

    更新日期：2009-05-29 00:00:00

  • Sex specific impact of different obesity phenotypes on the risk of incident hypertension: Tehran lipid and glucose study.

    abstract：Background:To investigate the association between different obesity phenotypes and the risk of incident hypertension among both genders. Methods:The study population included 3659 Iranians (men = 1540), aged ≥20 years free of hypertension at baseline. Participants were classified into six categories of body mass index...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-019-0340-0

    authors： Kabootari M,Akbarpour S,Azizi F,Hadaegh F

    更新日期：2019-02-27 00:00:00

  • Cinnamon extract inhibits α-glucosidase activity and dampens postprandial glucose excursion in diabetic rats.

    abstract：BACKGROUND:α-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion. PPHG is a major risk factor for diabetic vascular complications leading to disabilities and mortality in...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-8-46

    authors： Mohamed Sham Shihabudeen H,Hansi Priscilla D,Thirumurugan K

    更新日期：2011-06-29 00:00:00

  • Dietary selenium augments sarcoplasmic calcium release and mechanical performance in mice.

    abstract：BACKGROUND:As an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in redox-modulated calcium homeostasis and in protection against oxidative stress. METHODS:The effects of two diffe...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-016-0134-6

    authors： Bodnár D,Ruzsnavszky O,Oláh T,Dienes B,Balatoni I,Ungvári É,Benkő I,Babka B,Prokisch J,Csernoch L,Szentesi P

    更新日期：2016-11-03 00:00:00

  • Uncoupling proteins, dietary fat and the metabolic syndrome.

    abstract：:There has been intense interest in defining the functions of UCP2 and UCP3 during the nine years since the cloning of these UCP1 homologues. Current data suggest that both UCP2 and UCP3 proteins share some features with UCP1, such as the ability to reduce mitochondrial membrane potential, but they also have distinctly...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-3-38

    authors： Fisler JS,Warden CH

    更新日期：2006-09-12 00:00:00

  • Serum biomarkers of the calcium-deficient rats identified by metabolomics based on UPLC/Q-TOF MS/MS.

    abstract：BACKGROUND:We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS). To find biomarkers of calcium deficiency and further confirm these biomarkers in serum, we p...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-020-00507-2

    authors： Meng F,Fan L,Sun L,Yu Q,Wang M,Sun C

    更新日期：2020-11-23 00:00:00

  • Plasma homocysteine in adolescents depends on the interaction between methylenetetrahydrofolate reductase genotype, lipids and folate: a seroepidemiological study.

    abstract：BACKGROUND:Many publications link high homocysteine levels to cardiovascular disease. In Spain there is little information on the prevalence of hyperhomocysteinaemia and associated vitamin factors among the general population, and less still among children. Cardiovascular risk factors in the childhood population may be...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-6-39

    authors： Gil-Prieto R,Hernández V,Cano B,Oya M,Gil A

    更新日期：2009-10-05 00:00:00

  • Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size.

    abstract：Background:Caloric restriction since birth changes glucose metabolism by the liver in overnight-fasted rats to a fed-like pattern, in which glucose output is large but gluconeogenesis is negligible. It was investigated whether these changes could be a residual effect of the nutritional condition during lactation and wh...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/s12986-019-0413-0

    authors： Yamada LA,Mariano IR,Sabino VLR,Rabassi RS,Bataglini C,Azevedo SCSF,Branquinho NTD,Kurauti MA,Garcia RF,Pedrosa MMD

    更新日期：2019-12-12 00:00:00

  • Subcellular targeting domains of sphingomyelin synthase 1 and 2.

    abstract：: Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce SM and DAG, thereby regulating lipid messengers which play a role in cell survival and apoptosis. Furthermore, its product SM has ...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-8-89

    authors： Yeang C,Ding T,Chirico WJ,Jiang XC

    更新日期：2011-12-14 00:00:00

  • High-cholesterol diet enriched with onion affects endothelium-dependent relaxation and NADPH oxidase activity in mesenteric microvessels from Wistar rats.

    abstract：BACKGROUND:The aim of the present study was to examine the effects of onion as functional ingredient on the oxidative status, lipoprotein levels (total cholesterol-TC, HDL-C, LDL-C), triacylglycerides (TAG) and vascular reactivity of mesenteric arteries in hypercholesterolemic Wistar rats. METHODS:Twenty-four animals ...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-11-57

    authors： González-Peña D,Angulo J,Vallejo S,Colina-Coca C,de Ancos B,Sánchez-Ferrer CF,Peiró C,Sánchez-Moreno C

    更新日期：2014-12-23 00:00:00

  • Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation.

    abstract：BACKGROUND:Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fa...

    journal_title：Nutrition & metabolism

    pub_type： 杂志文章

    doi：10.1186/1743-7075-9-27

    authors： Jang HH,Park MY,Kim HW,Lee YM,Hwang KA,Park JH,Park DS,Kwon O

    更新日期：2012-03-30 00:00:00