Abstract：
BACKGROUND:Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This study was undertaken to determine whether 6-weeks of DHEA administration and/or exercise training improve insulin resistance in obese male rats. METHODS:After 14 weeks of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of four groups: control, DHEA administration, exercise training, and a combination of DHEA administration and exercise training (n = 10 each group). RESULTS:After 6-weeks of DHEA administration and/or exercise training, rats in the combination group weighed significantly less and had lower serum insulin levels than rats in the other groups. Moreover, the rats treated with DHEA alone or DHEA and exercise had significantly lower fasting glucose levels (combination, 84 ± 6.5 mg/dL; DHEA, 102 ± 9.5 mg/dL; control, 148 ± 10.5 mg/dL). In addition, insulin sensitivity check index showed significant improvements in the combination group (combination, 0.347 ± 0.11; exercise, 0.337 ± 0.16%; DHEA, 0.331 ± 0.14; control, 0.308 ± 0.12). Muscular DHEA and 5α-dihydrotestosterone (DHT) concentrations were significantly higher in the combination group, and closely correlated with the quantitative insulin-sensitivity check index (DHEA: r = 0.71, p < 0.01; DHT: r = 0.69, p < 0.01). CONCLUSION:These results showed that a combination of DHEA administration and exercise training effectively improved fasting blood glucose and insulin levels, and insulin sensitivity, which may reflect increased muscular DHEA and DHT concentrations.
journal_name
Nutr Metab (Lond)journal_title
Nutrition & metabolismauthors
Sato K,Iemitsu M,Aizawa K,Mesaki N,Ajisaka R,Fujita Sdoi
10.1186/1743-7075-9-47subject
Has Abstractpub_date
2012-05-30 00:00:00pages
47issn
1743-7075pii
1743-7075-9-47journal_volume
9pub_type
杂志文章abstract：:Glucocorticoids are stress hormones that modulate a large number of physiological actions involved in metabolic, inflammatory, cardiovascular and behavioral processes. The molecular mechanisms and the physiological effects of glucocorticoids have been extensively studied. However, the involvement of glucocorticoid act...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-2-3
更新日期：2005-02-02 00:00:00
abstract：: This paper reviews evidence in the context of current research linking dietary fructose to health risk markers.Fructose intake has recently received considerable media attention, most of which has been negative. The assertion has been that dietary fructose is less satiating and more lipogenic than other sugars. Howev...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-82
更新日期：2010-11-04 00:00:00
abstract：BACKGROUND:As an essential trace element selenium plays a significant role in many physiological functions of the organs. It is found within muscles as selenocystein in selenoprotein N, which is involved in redox-modulated calcium homeostasis and in protection against oxidative stress. METHODS:The effects of two diffe...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-016-0134-6
更新日期：2016-11-03 00:00:00
abstract：Background:Elderly people with type 2 diabetes mellitus (T2DM) have an increased risk of diabetes-related microvascular and macrovascular complications, thus diabetic patients with a functioning gastrointestinal tract but without sufficient oral intake require enteral nutrition (EN) formulas to control blood glucose. W...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0398-8
更新日期：2019-10-16 00:00:00
abstract：BACKGROUND:Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics. Several studies have indicated that children with autism spectrum disorders may have altered glutathione metabolism which could...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-35
更新日期：2012-04-24 00:00:00
abstract：: Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce SM and DAG, thereby regulating lipid messengers which play a role in cell survival and apoptosis. Furthermore, its product SM has ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-89
更新日期：2011-12-14 00:00:00
abstract：:Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-13
更新日期：2014-03-19 00:00:00
abstract：BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-50
更新日期：2011-07-12 00:00:00
abstract：Background:To investigate the association between different obesity phenotypes and the risk of incident hypertension among both genders. Methods:The study population included 3659 Iranians (men = 1540), aged ≥20 years free of hypertension at baseline. Participants were classified into six categories of body mass index...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-019-0340-0
更新日期：2019-02-27 00:00:00
abstract：:An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, P...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,评审
doi：10.1186/s12986-017-0233-z
更新日期：2017-12-22 00:00:00
abstract：Background:Diet and exercise play important roles in ameliorating metabolic syndrome. Yunkang 10 (Camellia sinensis var. assamica) is a most cultivated tea variety for making tea in the Southwestern China. Currently, there is no report of healthy effects of Yunkang 10 green tea (YKGT) and treadmill exercise (Ex) on hig...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-0433-9
更新日期：2020-02-04 00:00:00
abstract：: Prior to the discovery of medical treatment for diabetes, carbohydrate-restriction was the predominant treatment recommendation to treat diabetes mellitus. In this commentary we argue that carbohydrate-restriction should be reincorporated into contemporary treatment studies for diabetes mellitus. ...
journal_title：Nutrition & metabolism
pub_type： 社论
doi：10.1186/1743-7075-5-10
更新日期：2008-04-09 00:00:00
abstract：Background:Obesity has been identified as a major risk factor for a large number of chronic diseases. Understanding factors related to adolescent obesity is critical for prevention of chronic diseases. The associations between sleep duration and obesity among adolescents in the existing literature are controversial. Ou...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0285-8
更新日期：2018-07-09 00:00:00
abstract：BACKGROUND:The protective effect of HDL is mostly attributed to their metabolic function in reverse cholesterol transport (RCT), a process whereby excess cellular cholesterol is taken up from peripheral cells, processed in HDL particles, and later delivered to the liver for further metabolism and biliary secretion. Mec...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-10-67
更新日期：2013-11-06 00:00:00
abstract：PURPOSE:To determine the influence of menstrual irregularity, oral contraceptive use and other factors on bone mineral density (BMD) and bone size at different skeletal sites in 135 college-aged fit women. METHODS:Menstrual history, oral contraceptive use, exercise history, and nutritional factors including calcium, c...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-4-17
更新日期：2007-08-06 00:00:00
abstract：: Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially di...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-63
更新日期：2012-06-27 00:00:00
abstract：Objective:We aimed to describe the 25-hydroxyvitamin D (25(OH)D) status of southern Chinese individuals by a high-accuracy liquid chromatography tandem mass spectrometry (LC-MS/MS) method which can trace to reference measurement procedure. Materials and methods:From January 2018 to June 2019, a total of 4775 southern ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-0427-7
更新日期：2020-01-17 00:00:00
abstract：BACKGROUND:α-glucosidase inhibitors regulate postprandial hyperglycemia (PPHG) by impeding the rate of carbohydrate digestion in the small intestine and thereby hampering the diet associated acute glucose excursion. PPHG is a major risk factor for diabetic vascular complications leading to disabilities and mortality in...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-8-46
更新日期：2011-06-29 00:00:00
abstract：:Propolis is a sticky, resinous material gather from plants and is blended with wax and other constituents. It is reported to have anti-inflammatory, anti-oxidative and blood glucose-lowering properties. This review aims to summarise evidences for the cellular and molecular mechanism of Propolis in inflammation, oxidat...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00485-5
更新日期：2020-08-12 00:00:00
abstract：: A large volume of human clinical data supports increased dietary protein for favorable changes to body composition, but not all data are conclusive. The aim of this review is to propose two theories, "protein spread theory" and "protein change theory" in an effort to explain discrepancies in the literature. Protein s...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-9-81
更新日期：2012-09-12 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12986-018-0305-8.]. ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12986-018-0311-x
更新日期：2018-10-18 00:00:00
abstract：Background:NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations. Due to its dangerous aftermaths, finding new substances, such as polyphenols and their derivatives,...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-017-0223-1
更新日期：2017-11-13 00:00:00
abstract：:OBJECTIVE: To compare the effects of isocaloric, energy-restricted very low-carbohydrate ketogenic (VLCK) and low-fat (LF) diets on weight loss, body composition, trunk fat mass, and resting energy expenditure (REE) in overweight/obese men and women. DESIGN: Randomized, balanced, two diet period clinical intervention ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-1-13
更新日期：2004-11-08 00:00:00
abstract：Background:The relationship between selenium (Se) and insulin resistance remains unclear. We aim to explore the association between toenail Se levels and insulin resistance through a cross-sectional study comprising Chinese vegetarians and matched omnivores. Methods:In this study, we enrolled 220 vegetarians and 220 o...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00484-6
更新日期：2020-08-03 00:00:00
abstract：BACKGROUND:Dihydrocapsiate (DCT) is a natural safe food ingredient which is structurally related to capsaicin from chili pepper and is found in the non-pungent pepper strain, CH-19 Sweet. It has been shown to elicit the thermogenic effects of capsaicin but without its gastrointestinal side effects. METHODS:The present...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-7-78
更新日期：2010-10-06 00:00:00
abstract：BACKGROUND:Body volume expands with the positive energy balance associated with the development of adult human obesity and this "growth" is captured by two widely used clinical metrics, waist circumference and body mass index (BMI). Empirical correlations between circumferences, BMI, and related body compartments are f...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-5-24
更新日期：2008-10-06 00:00:00
abstract：BACKGROUND:A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous ...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/1743-7075-11-50
更新日期：2014-10-18 00:00:00
abstract：BACKGROUND:Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored. The present study was to investigate the effects of hawthorn fruit extrac...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00535-y
更新日期：2021-01-07 00:00:00
abstract：Background:The aim of this study was to investigate how the signaling pathway downstream of mTOR/S6K1 contributes to the regulation of SREBP-1c expression during lipogenesis in HepG2 cells. Methods:The model of steatosis was established using human hepatocytes HepG2 and inducting them with sodium palmitate. mTOR, S6K1...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-018-0268-9
更新日期：2018-05-02 00:00:00
abstract：BACKGROUND:We previously identified the urinary biomarkers to diagnose calcium deficiency and nutritional rickets by ultra-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF MS/MS). To find biomarkers of calcium deficiency and further confirm these biomarkers in serum, we p...
journal_title：Nutrition & metabolism
pub_type： 杂志文章
doi：10.1186/s12986-020-00507-2
更新日期：2020-11-23 00:00:00
