Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis.

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H215O (or C15O2) can quantify CBF and apply kinetic analyses, including autoradiography (ARG) and the basis function methods (BFM). These approache...

journal_title：EJNMMI research

authors： Kudomi N,Maeda Y,Sasakawa Y,Monden T,Yamamoto Y,Kawai N,Iida H,Nishiyama Y

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...

journal_title：EJNMMI research

authors： Wu WJ,Li ZY,Dong S,Liu SM,Zheng L,Huang MW,Zhang JG

更新日期：2019-09-11 00:00:00

abstract：:Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-...

journal_title：EJNMMI research

authors： Fujita M,Kobayashi M,Ikawa M,Gunn RN,Rabiner EA,Owen DR,Zoghbi SS,Haskali MB,Telu S,Pike VW,Innis RB

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows ...

journal_title：EJNMMI research

authors： Gustafsson J,Sundlöv A,Sjögreen Gleisner K

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:[11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by optimizing the timing of initiation of the scan and applying correction to the plasma concentrati...

journal_title：EJNMMI research

authors： Isohashi K,Shimosegawa E,Kato H,Kanai Y,Naka S,Fujino K,Watabe H,Hatazawa J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab'-fragment directed against TNF. A biodistribution and do...

journal_title：EJNMMI research

authors： Lambert B,Carron P,D'Asseler Y,Bacher K,Van den Bosch F,Elewaut D,Verbruggen G,Beyaert R,Dumolyn C,De Vos F

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel 18F-FDG activity remains unknown. RESULTS:We included 63 healthy male subjects....

journal_title：EJNMMI research

authors： Kang JY,Kim HN,Chang Y,Yun Y,Ryu S,Shin H,Kim HL

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prosta...

journal_title：EJNMMI research

authors： Lake ST,Greene KL,Westphalen AC,Behr SC,Zagoria R,Small EJ,Carroll PR,Hope TA

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have impleme...

journal_title：EJNMMI research

authors： Spangler-Bickell MG,de Laat B,Fulton R,Bormans G,Nuyts J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improv...

journal_title：EJNMMI research

authors： Braat MNGJA,de Jong HW,Seinstra BA,Scholten MV,van den Bosch MAAJ,Lam MGEH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anat...

journal_title：EJNMMI research

authors： Werner P,Rullmann M,Bresch A,Tiepolt S,Jochimsen T,Lobsien D,Schroeter ML,Sabri O,Barthel H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...

journal_title：EJNMMI research

authors： Kanazawa M,Nishiyama S,Hashimoto F,Kakiuchi T,Tsukada H

更新日期：2018-06-13 00:00:00

abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

journal_title：EJNMMI research

authors： Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...

journal_title：EJNMMI research

authors： Morooka M,Moroi M,Uno K,Ito K,Wu J,Nakagawa T,Kubota K,Minamimoto R,Miyata Y,Okasaki M,Okazaki O,Yamada Y,Yamaguchi T,Hiroe M

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examin...

journal_title：EJNMMI research

authors： Bak-Fredslund KP,Lykke Eriksen P,Munk OL,Villadsen GE,Keiding S,Sørensen M

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

journal_title：EJNMMI research

authors： Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...

journal_title：EJNMMI research

authors： van Roekel C,Jongen JMJ,Smits MLJ,Elias SG,Koopman M,Kranenburg O,Borel Rinkes IHM,Lam MGEH

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...

journal_title：EJNMMI research

authors： Pérès EA,Toutain J,Paty LP,Divoux D,Ibazizène M,Guillouet S,Barré L,Vidal A,Cherel M,Bourgeois M,Bernaudin M,Valable S

更新日期：2019-12-19 00:00:00

abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

journal_title：EJNMMI research

authors： Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

更新日期：2019-02-20 00:00:00

abstract：UNLABELLED: BACKGROUND:An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung...

journal_title：EJNMMI research

authors： Gibney BC,Park MA,Chamoto K,Ysasi A,Konerding MA,Tsuda A,Mentzer SJ

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...

journal_title：EJNMMI research

authors： Dalmo J,Spetz J,Montelius M,Langen B,Arvidsson Y,Johansson H,Parris TZ,Helou K,Wängberg B,Nilsson O,Ljungberg M,Forssell-Aronsson E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...

journal_title：EJNMMI research

authors： Akamatsu G,Ikari Y,Ohnishi A,Matsumoto K,Nishida H,Yamamoto Y,Senda M,Japanese Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...

journal_title：EJNMMI research

authors： Dalmo J,Westberg E,Barregard L,Svedbom L,Johansson M,Törnqvist M,Forssell-Aronsson E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targetin...

journal_title：EJNMMI research

authors： Erlandsson A,Forssell-Aronsson E,Seidal T,Bernhardt P

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

journal_title：EJNMMI research

authors： Pérez-Carro R,Cauli O,López-Larrubia P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear u...

journal_title：EJNMMI research

authors： Amor D,Goutal S,Marie S,Caillé F,Bauer M,Langer O,Auvity S,Tournier N

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...

journal_title：EJNMMI research

authors： Parent MJ,Cyr M,Aliaga A,Kostikov A,Schirrmacher E,Soucy JP,Mechawar N,Rosa-Neto P,Bedard MA

更新日期：2013-10-09 00:00:00