Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats.

Abstract:

BACKGROUND:Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear uptake transport of erlotinib into the liver, suggesting carrier-mediated system(s) to mediate its hepatobiliary clearance. Erlotinib has been identified in vitro as a substrate of organic anion-transporting polypeptide (OATP) transporters which expression does not restrict to hepatocytes and may impact the tissue uptake of erlotinib in vivo. RESULTS:The impact of rifampicin (40 mg/kg), a potent OATP inhibitor, on the liver uptake and exposure to tissues of 11C-erlotinib was investigated in rats (4 animals per group) using positron emission tomography (PET) imaging. Tissue pharmacokinetics (PK) and corresponding exposure (area under the curve, AUC) were assessed in the liver, kidney cortex, abdominal aorta (blood pool) and the lungs. The plasma PK of parent 11C-erlotinib was also measured using arterial blood sampling to estimate the transfer rate constant (kuptake) of 11C-erlotinib from plasma into different tissues. PET images unveiled the predominant distribution of 11C-erlotinib-associated radioactivity to the liver, which gradually moved to the intestine, thus highlighting hepatobiliary clearance. 11C-erlotinib also accumulated in the kidney cortex. Rifampicin did not impact AUCaorta but reduced kuptake, liver (p < 0.001), causing a significant 27.3% decrease in liver exposure (p < 0.001). Moreover, a significant decrease in kuptake, kidney with a concomitant decrease in AUCkidney (- 30.4%, p < 0.001) were observed. Rifampicin neither affected kuptake, lung nor AUClung. CONCLUSIONS:Our results suggest that 11C-erlotinib is an in vivo substrate of rOATP transporters expressed in the liver and possibly of rifampicin-inhibitable transporter(s) in the kidneys. Decreased 11C-erlotinib uptake by elimination organs did not translate into changes in systemic exposure and exposure to the lungs, which are a target tissue for erlotinib therapy.

journal_name

EJNMMI Res

journal_title

EJNMMI research

authors

Amor D,Goutal S,Marie S,Caillé F,Bauer M,Langer O,Auvity S,Tournier N

doi

10.1186/s13550-018-0434-0

subject

Has Abstract

pub_date

2018-08-16 00:00:00

pages

81

issue

1

issn

2191-219X

pii

10.1186/s13550-018-0434-0

journal_volume

8

pub_type

杂志文章
  • 18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy.

    abstract:BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-00728-9

    authors: Malviya G,Patel R,Salji M,Martinez RS,Repiscak P,Mui E,Champion S,Mrowinska A,Johnson E,AlRasheedi M,Pimlott S,Lewis D,Leung HY

    更新日期:2020-11-25 00:00:00

  • Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer.

    abstract:BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-0596-4

    authors: Derwael C,Lavergne O,Lovinfosse P,Nechifor V,Salvé M,Waltregny D,Hustinx R,Withofs N

    更新日期:2020-02-28 00:00:00

  • 68Ga-PSMA PET/CT in radioactive iodine-refractory differentiated thyroid cancer and first treatment results with 177Lu-PSMA-617.

    abstract:BACKGROUND:Differentiated thyroid carcinoma (DTC) is the most common type of thyroid cancer. Treatment with surgery, radioactive iodine (RAI), and TSH suppression is effective in most patients. Five to 15% of patients become RAI refractory and need alternative therapy; however, treatment options are limited. 68Ga-PSMA ...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-0610-x

    authors: de Vries LH,Lodewijk L,Braat AJAT,Krijger GC,Valk GD,Lam MGEH,Borel Rinkes IHM,Vriens MR,de Keizer B

    更新日期:2020-03-06 00:00:00

  • Non-invasive molecular imaging of inflammatory macrophages in allograft rejection.

    abstract:BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-015-0146-7

    authors: O'Neill AS,Terry SY,Brown K,Meader L,Wong AM,Cooper JD,Crocker PR,Wong W,Mullen GE

    更新日期:2015-12-01 00:00:00

  • [18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer.

    abstract:PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-019-0587-5

    authors: Jouberton E,Schmitt S,Chautard E,Maisonial-Besset A,Roy M,Radosevic-Robin N,Chezal JM,Miot-Noirault E,Bouvet Y,Cachin F

    更新日期:2020-01-06 00:00:00

  • Correction to: Neurologically asymptomatic cerebral oligometastatic prostate carcinoma metastasis identified on [Ga]Ga-THP-PSMA PET/CT.

    abstract::An amendment to this paper has been published and can be accessed via the original article. ...

    journal_title:EJNMMI research

    pub_type: 已发布勘误

    doi:10.1186/s13550-020-00719-w

    authors: Ross MI,Bird N,Mendichovszky IA,Rimmer YL

    更新日期:2020-10-27 00:00:00

  • A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus.

    abstract:BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-018-0432-2

    authors: Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

    更新日期:2018-08-15 00:00:00

  • Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients.

    abstract:BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-016-0212-9

    authors: Bowen SR,Chapman TR,Borgman J,Miyaoka RS,Kinahan PE,Liou IW,Sandison GA,Vesselle HJ,Nyflot MJ,Apisarnthanarax S

    更新日期:2016-12-01 00:00:00

  • Peptide receptor radionuclide therapy (PRRT) with [(177)Lu-DOTA(0),Tyr(3)]octreotate in combination with RAD001 treatment: further investigations on tumor metastasis and response in the rat pancreatic CA20948 tumor model.

    abstract:BACKGROUND:Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) (Cancer Res. 73:12-8, 2013). Moreover, the combination th...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-014-0021-y

    authors: Bison SM,Pool SE,Koelewijn SJ,van der Graaf LM,Groen HC,Melis M,de Jong M

    更新日期:2014-05-30 00:00:00

  • Development and evaluation of a rapid analysis for HEPES determination in 68Ga-radiotracers.

    abstract:BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-018-0449-6

    authors: Pfaff S,Nehring T,Pichler V,Cardinale J,Mitterhauser M,Hacker M,Wadsak W

    更新日期:2018-10-23 00:00:00

  • Reproducibility of 18F-fluoromisonidazole intratumour distribution in non-small cell lung cancer.

    abstract:BACKGROUND:Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMI...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-016-0210-y

    authors: Grkovski M,Schwartz J,Rimner A,Schöder H,Carlin SD,Zanzonico PB,Humm JL,Nehmeh SA

    更新日期:2016-12-01 00:00:00

  • A comparative 18F-FDG PET/CT imaging of experimental Staphylococcus aureus osteomyelitis and Staphylococcus epidermidis foreign-body-associated infection in the rabbit tibia.

    abstract:BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-2-41

    authors: Lankinen P,Lehtimäki K,Hakanen AJ,Roivainen A,Aro HT

    更新日期:2012-07-23 00:00:00

  • Multiparametric magnetic resonance in the assessment of the gender differences in a high-grade glioma rat model.

    abstract:BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-014-0044-4

    authors: Pérez-Carro R,Cauli O,López-Larrubia P

    更新日期:2014-12-01 00:00:00

  • Pilot study of PET imaging of 124I-iodoazomycin galactopyranoside (IAZGP), a putative hypoxia imaging agent, in patients with colorectal cancer and head and neck cancer.

    abstract:BACKGROUND:Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in pa...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-3-42

    authors: O'Donoghue JA,Guillem JG,Schöder H,Lee NY,Divgi CR,Ruby JA,Humm JL,Lee-Kong SA,Burnazi EM,Cai S,Carlin SD,Leibold T,Zanzonico PB,Ling CC

    更新日期:2013-06-03 00:00:00

  • 64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study.

    abstract:BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-019-0586-6

    authors: Pérès EA,Toutain J,Paty LP,Divoux D,Ibazizène M,Guillouet S,Barré L,Vidal A,Cherel M,Bourgeois M,Bernaudin M,Valable S

    更新日期:2019-12-19 00:00:00

  • Phantom and clinical evaluation of bone SPECT/CT image reconstruction with xSPECT algorithm.

    abstract:BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-00659-5

    authors: Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

    更新日期:2020-06-29 00:00:00

  • Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry.

    abstract:BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-3-70

    authors: Parent MJ,Cyr M,Aliaga A,Kostikov A,Schirrmacher E,Soucy JP,Mechawar N,Rosa-Neto P,Bedard MA

    更新日期:2013-10-09 00:00:00

  • Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios.

    abstract::Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-...

    journal_title:EJNMMI research

    pub_type: 信件

    doi:10.1186/s13550-017-0334-8

    authors: Fujita M,Kobayashi M,Ikawa M,Gunn RN,Rabiner EA,Owen DR,Zoghbi SS,Haskali MB,Telu S,Pike VW,Innis RB

    更新日期:2017-10-16 00:00:00

  • dAcquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system.

    abstract:BACKGROUND:Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-2-7

    authors: Anizan N,Carlier T,Hindorf C,Barbet J,Bardiès M

    更新日期:2012-02-13 00:00:00

  • First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9.

    abstract:BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-018-0462-9

    authors: Gnesin S,Cicone F,Mitsakis P,Van der Gucht A,Baechler S,Miralbell R,Garibotto V,Zilli T,Prior JO

    更新日期:2018-12-12 00:00:00

  • Imaging VEGF receptor expression to identify accelerated atherosclerosis.

    abstract:BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-014-0041-7

    authors: Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

    更新日期:2014-12-01 00:00:00

  • Imaging of the appearance time of cerebral blood using [15O]H2O PET for the computation of correct CBF.

    abstract:BACKGROUND:Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H215O (or C15O2) can quantify CBF and apply kinetic analyses, including autoradiography (ARG) and the basis function methods (BFM). These approache...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-3-41

    authors: Kudomi N,Maeda Y,Sasakawa Y,Monden T,Yamamoto Y,Kawai N,Iida H,Nishiyama Y

    更新日期:2013-05-23 00:00:00

  • The power of FDG-PET to detect treatment effects is increased by glucose correction using a Michaelis constant.

    abstract:BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-2-35

    authors: Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

    更新日期:2012-06-27 00:00:00

  • Assessment of regional pulmonary blood flow using 68Ga-DOTA PET.

    abstract:BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-017-0259-2

    authors: Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

    更新日期:2017-12-01 00:00:00

  • Effects of attenuation map accuracy on attenuation-corrected micro-SPECT images.

    abstract:UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/2191-219X-3-7

    authors: Wu C,Gratama van Andel HA,Laverman P,Boerman OC,Beekman FJ

    更新日期:2013-01-31 00:00:00

  • Diagnostic value of PET/CT with 11C-methionine (MET) and 18F-fluorothymidine (FLT) in newly diagnosed glioma based on the 2016 WHO classification.

    abstract:BACKGROUND:The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[18F...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-00633-1

    authors: Ogawa T,Kawai N,Miyake K,Shinomiya A,Yamamoto Y,Nishiyama Y,Tamiya T

    更新日期:2020-05-07 00:00:00

  • Targeted beta therapy of prostate cancer with 177Lu-labelled Miltuximab® antibody against glypican-1 (GPC-1).

    abstract:PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-00637-x

    authors: Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

    更新日期:2020-05-07 00:00:00

  • Kinetic analysis of HER2-binding ABY-025 Affibody molecule using dynamic PET in patients with metastatic breast cancer.

    abstract:BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-0603-9

    authors: Alhuseinalkhudhur A,Lubberink M,Lindman H,Tolmachev V,Frejd FY,Feldwisch J,Velikyan I,Sörensen J

    更新日期:2020-03-23 00:00:00

  • Double-strand breaks in lymphocyte DNA of humans exposed to [18F]fluorodeoxyglucose and the static magnetic field in PET/MRI.

    abstract:BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-020-00625-1

    authors: Brix G,Günther E,Rössler U,Endesfelder D,Kamp A,Beer A,Eiber M

    更新日期:2020-04-28 00:00:00

  • Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity.

    abstract:BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...

    journal_title:EJNMMI research

    pub_type: 杂志文章

    doi:10.1186/s13550-019-0570-1

    authors: Lindberg A,Arakawa R,Nogami T,Nag S,Schou M,Elmore CS,Farde L,Pike VW,Halldin C

    更新日期:2019-11-21 00:00:00