Abstract：
BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improve patient selection and treatment planning. A case series will be presented to illustrate the potential of this technique. Hepatocellular carcinoma patients with cirrhosis (Child-Pugh A and B) underwent hepatobiliary scintigraphy pre- and 3 months post-radioembolization as part of a prospective study protocol, which was prematurely terminated because of limited accrual. Included patients were analysed together with their clinical, laboratory and treatment data. RESULTS:Pretreatment-corrected 99mTc-mebrofenin liver uptake rates were marginal (1.8-3.0%/min/m2), despite acceptable clinical and laboratory parameters. Posttreatment liver functions seriously declined (corrected 99mTc-mebrofenin liver uptake rates: 0.6-2.4%/min/m2), resulting in lethal radioembolization-induced liver disease in two out of three patients. CONCLUSIONS:Hepatobiliary scintigraphy may be of added value during work-up for radioembolization, to estimate liver function reserve and its segmental distribution, especially in patients with underlying cirrhosis, for whom analysis of clinical and laboratory parameters may not be sufficient.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Braat MNGJA,de Jong HW,Seinstra BA,Scholten MV,van den Bosch MAAJ,Lam MGEHdoi
10.1186/s13550-016-0248-xsubject
Has Abstractpub_date
2017-12-01 00:00:00pages
2issue
1issn
2191-219Xpii
10.1186/s13550-016-0248-xjournal_volume
7pub_type
杂志文章相关文献
EJNMMI Research文献大全abstract：BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00728-9
更新日期：2020-11-25 00:00:00
abstract：BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00745-8
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0212-9
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0041-7
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-3-12
更新日期：2013-02-25 00:00:00
abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0199-2
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00625-1
更新日期：2020-04-28 00:00:00
abstract：BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-2-41
更新日期：2012-07-23 00:00:00
abstract：BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examin...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-017-0320-1
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studi...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0235-2
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT), we generated stable cell lines that express a yellow-fluorescent protein (YFP) and Gaussia lucife...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0032-8
更新日期：2014-06-26 00:00:00
abstract：:Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseas...
journal_title：EJNMMI research
pub_type： 杂志文章,评审
doi：10.1186/s13550-021-00750-5
更新日期：2021-01-19 00:00:00
abstract：INTRODUCTION:The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. METHODS:For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) o...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0396-2
更新日期：2018-06-11 00:00:00
abstract：BACKGROUND:Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their pr...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0080-0
更新日期：2015-02-12 00:00:00
abstract：BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-0591-9
更新日期：2020-02-10 00:00:00
abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0074-y
更新日期：2014-12-24 00:00:00
abstract：: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-1-9
更新日期：2011-07-26 00:00:00
abstract：BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-019-0575-9
更新日期：2019-12-09 00:00:00
abstract：BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-019-0561-2
更新日期：2019-09-18 00:00:00
abstract：BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-019-0543-4
更新日期：2019-08-02 00:00:00
abstract：BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-019-0505-x
更新日期：2019-06-13 00:00:00
abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00659-5
更新日期：2020-06-29 00:00:00
abstract：UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-2-55
更新日期：2012-09-29 00:00:00
abstract：BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00718-x
更新日期：2020-10-19 00:00:00
abstract：PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-019-0587-5
更新日期：2020-01-06 00:00:00
abstract：BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0375-7
更新日期：2018-03-09 00:00:00
abstract：BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00626-0
更新日期：2020-05-12 00:00:00
abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-019-0485-x
更新日期：2019-02-20 00:00:00
abstract：BACKGROUND:Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMI...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0210-y
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS:The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand bindi...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0465-6
更新日期：2018-12-27 00:00:00
