Abstract:
BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examined whether the standardised uptake value (SUV) of 18F-FDGal from static scans can substitute the hepatic systemic clearance of 18F-FDGal (K met, mL blood/min/mL liver tissue/) quantified from dynamic scans as measure of metabolic function. Four patients with cirrhosis and six healthy subjects underwent two 18F-FDGal PET/CT scans within a median interval of 15 days for determination of day-to-day variation. The correlation between K met and SUV was examined using scan data and measured arterial blood concentrations of 18F-FDGal (blood samples) from 14 subjects from previous studies. Regional and whole-liver values of K met and SUV along with total metabolic liver volume and total metabolic liver function (total SUV, average SUV multiplied by total metabolic liver volume) were calculated. RESULTS:No significant day-to-day differences were found for K met or SUV. SUV had higher intraclass correlation coefficients than K met (0.92-0.97 vs. 0.49-0.78). The relationship between K met and SUV was linear. Total metabolic liver volume had non-significant day-to-day variation (median difference 50 mL liver tissue; P = 0.6). Mean total SUV in healthy subjects was 23,840 (95% CI, 21,609; 26,070), significantly higher than in the patients (P < 0.001). CONCLUSIONS:The reproducibility of 18F-FDGal PET/CT was good and SUV can substitute K met for quantification of hepatic metabolic function. Total SUV of 18F-FDGal is a promising tool for quantification of metabolic liver function in pre-treatment evaluation of individual patients.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Bak-Fredslund KP,Lykke Eriksen P,Munk OL,Villadsen GE,Keiding S,Sørensen Mdoi
10.1186/s13550-017-0320-1subject
Has Abstractpub_date
2017-08-29 00:00:00pages
71issue
1issn
2191-219Xpii
10.1186/s13550-017-0320-1journal_volume
7pub_type
杂志文章相关文献
EJNMMI Research文献大全abstract:BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-0594-6
更新日期:2020-02-24 00:00:00
abstract:BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0330-z
更新日期:2017-10-03 00:00:00
abstract:PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0485-x
更新日期:2019-02-20 00:00:00
abstract:PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00637-x
更新日期:2020-05-07 00:00:00
abstract:BACKGROUND:Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. 18F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMI...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0210-y
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0074-y
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective hypoxic marker. They also highlighted that the results may be tum...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0586-6
更新日期:2019-12-19 00:00:00
abstract:BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improv...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0248-x
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0059-x
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their pr...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0080-0
更新日期:2015-02-12 00:00:00
abstract:BACKGROUND:Somatostatin receptor (SST) targeting, specifically of the subtype 2 (SST2), with radiolabeled somatostatin analogs, is established for imaging and treatment of neuroendocrine tumors. Owing to the concomitant and heterogeneous expression of several subtypes on the same tumor, analogs targeting more subtypes ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00677-3
更新日期:2020-08-05 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-4-6
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0551-4
更新日期:2019-09-04 00:00:00
abstract:BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0567-9
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0570-1
更新日期:2019-11-21 00:00:00
abstract:BACKGROUND:Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-7
更新日期:2012-02-13 00:00:00
abstract:BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-3-12
更新日期:2013-02-25 00:00:00
abstract:BACKGROUND:In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemic...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0515-8
更新日期:2019-05-16 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0555-0
更新日期:2019-09-11 00:00:00
abstract:BACKGROUND:To assess 18-fluorodeoxyglucose (FDG) bowel uptake in patients with differentiated thyroid cancer (DTC) treated with sorafenib. FINDINGS:Visual (5-point scale) and high maximum standard uptake value (SUVmax) semi-quantitative analyses were conducted in 63 positron emission tomography (PET) studies performed...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-18
更新日期:2012-05-07 00:00:00
abstract:BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/2191-219X-2-35
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-015-0100-8
更新日期:2015-04-02 00:00:00
abstract:BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-014-0073-z
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0247-y
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prosta...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0327-7
更新日期:2017-09-19 00:00:00
abstract:BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-020-00718-x
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-016-0212-9
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-017-0269-0
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...
journal_title:EJNMMI research
pub_type: 杂志文章
doi:10.1186/s13550-019-0575-9
更新日期:2019-12-09 00:00:00
abstract::Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-...
journal_title:EJNMMI research
pub_type: 信件
doi:10.1186/s13550-017-0334-8
更新日期:2017-10-16 00:00:00