Sorafenib increases 18-FDG colic uptake: demonstration in patients with differentiated thyroid cancer.

abstract：UNLABELLED: BACKGROUND:An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung...

journal_title：EJNMMI research

authors： Gibney BC,Park MA,Chamoto K,Ysasi A,Konerding MA,Tsuda A,Mentzer SJ

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

journal_title：EJNMMI research

authors： Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

journal_title：EJNMMI research

authors： Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have impleme...

journal_title：EJNMMI research

authors： Spangler-Bickell MG,de Laat B,Fulton R,Bormans G,Nuyts J

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...

journal_title：EJNMMI research

authors： Jouberton E,Schmitt S,Chautard E,Maisonial-Besset A,Roy M,Radosevic-Robin N,Chezal JM,Miot-Noirault E,Bouvet Y,Cachin F

更新日期：2020-01-06 00:00:00

abstract：: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...

journal_title：EJNMMI research

authors： Moncayo R

更新日期：2011-07-26 00:00:00

abstract：BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...

journal_title：EJNMMI research

authors： Pfaff S,Nehring T,Pichler V,Cardinale J,Mitterhauser M,Hacker M,Wadsak W

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...

journal_title：EJNMMI research

authors： Suzuki C,Kosugi M,Magata Y

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

journal_title：EJNMMI research

authors： Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognost...

journal_title：EJNMMI research

authors： Reza M,Bjartell A,Ohlsson M,Kaboteh R,Wollmer P,Edenbrandt L,Trägårdh E

更新日期：2014-10-17 00:00:00

abstract：BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...

journal_title：EJNMMI research

authors： Derwael C,Lavergne O,Lovinfosse P,Nechifor V,Salvé M,Waltregny D,Hustinx R,Withofs N

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:[11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by optimizing the timing of initiation of the scan and applying correction to the plasma concentrati...

journal_title：EJNMMI research

authors： Isohashi K,Shimosegawa E,Kato H,Kanai Y,Naka S,Fujino K,Watabe H,Hatazawa J

更新日期：2013-04-15 00:00:00

abstract：INTRODUCTION:The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. METHODS:For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) o...

journal_title：EJNMMI research

authors： McGinnity CJ,Riaño Barros DA,Trigg W,Brooks DJ,Hinz R,Duncan JS,Koepp MJ,Hammers A

更新日期：2018-06-11 00:00:00

abstract：BACKGROUND:We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel 18F-FDG activity remains unknown. RESULTS:We included 63 healthy male subjects....

journal_title：EJNMMI research

authors： Kang JY,Kim HN,Chang Y,Yun Y,Ryu S,Shin H,Kim HL

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...

journal_title：EJNMMI research

authors： Elekonawo FMK,Lütje S,Franssen GM,Bos DL,Goldenberg DM,Boerman OC,Rijpkema M

更新日期：2019-09-04 00:00:00

abstract：BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...

journal_title：EJNMMI research

authors： Gnesin S,Cicone F,Mitsakis P,Van der Gucht A,Baechler S,Miralbell R,Garibotto V,Zilli T,Prior JO

更新日期：2018-12-12 00:00:00

abstract：UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...

journal_title：EJNMMI research

authors： Pitkonen M,Hippeläinen E,Raki M,Andressoo JO,Urtti A,Männistö PT,Savolainen S,Saarma M,Bergström K

更新日期：2012-09-29 00:00:00

abstract：BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...

journal_title：EJNMMI research

authors： Chan HS,Konijnenberg MW,Daniels T,Nysus M,Makvandi M,de Blois E,Breeman WA,Atcher RW,de Jong M,Norenberg JP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...

journal_title：EJNMMI research

authors： O'Neill AS,Terry SY,Brown K,Meader L,Wong AM,Cooper JD,Crocker PR,Wong W,Mullen GE

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...

journal_title：EJNMMI research

authors： Parent MJ,Cyr M,Aliaga A,Kostikov A,Schirrmacher E,Soucy JP,Mechawar N,Rosa-Neto P,Bedard MA

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...

journal_title：EJNMMI research

authors： Boswijk E,Franssen R,Vijgen GHEJ,Wierts R,van der Pol JAJ,Mingels AMA,Cornips EMJ,Majoie MHJM,van Marken Lichtenbelt WD,Mottaghy FM,Wildberger JE,Bucerius J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization...

journal_title：EJNMMI research

authors： van Roekel C,Jongen JMJ,Smits MLJ,Elias SG,Koopman M,Kranenburg O,Borel Rinkes IHM,Lam MGEH

更新日期：2020-09-22 00:00:00

abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

journal_title：EJNMMI research

authors： Pérez-Carro R,Cauli O,López-Larrubia P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...

journal_title：EJNMMI research

authors： Lindberg A,Arakawa R,Nogami T,Nag S,Schou M,Elmore CS,Farde L,Pike VW,Halldin C

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:The availability of GABAA receptor binding sites in the brain can be assessed by positron emission tomography (PET) using the radioligand, [18F]flumazenil. However, the brain uptake and binding of this PET radioligand are influenced by anesthetic drugs, which are typically needed in preclinical imaging studi...

journal_title：EJNMMI research

authors： Palner M,Beinat C,Banister S,Zanderigo F,Park JH,Shen B,Hjoernevik T,Jung JH,Lee BC,Kim SE,Fung L,Chin FT

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs. For non-small cel...

journal_title：EJNMMI research

authors： Slobbe P,Windhorst AD,Stigter-van Walsum M,Smit EF,Niessen HG,Solca F,Stehle G,van Dongen GA,Poot AJ

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...

journal_title：EJNMMI research

authors： Owaki Y,Nakahara T,Kosaka T,Fukada J,Kumabe A,Ichimura A,Murakami M,Nakajima K,Fukushi M,Inoue K,Oya M,Jinzaki M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00