Bone Scan Index as a prognostic imaging biomarker during androgen deprivation therapy.

abstract：BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...

journal_title：EJNMMI research

authors： Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

更新日期：2018-08-15 00:00:00

abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

journal_title：EJNMMI research

authors： Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...

journal_title：EJNMMI research

authors： Dalmo J,Westberg E,Barregard L,Svedbom L,Johansson M,Törnqvist M,Forssell-Aronsson E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anat...

journal_title：EJNMMI research

authors： Werner P,Rullmann M,Bresch A,Tiepolt S,Jochimsen T,Lobsien D,Schroeter ML,Sabri O,Barthel H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) (Cancer Res. 73:12-8, 2013). Moreover, the combination th...

journal_title：EJNMMI research

authors： Bison SM,Pool SE,Koelewijn SJ,van der Graaf LM,Groen HC,Melis M,de Jong M

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...

journal_title：EJNMMI research

authors： Taralli S,Sollini M,Milella M,Perotti G,Filice A,Menga M,Versari A,Rufini V

更新日期：2018-07-21 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...

journal_title：EJNMMI research

authors： Schimmelpennink MC,Vorselaars ADM,Veltkamp M,Keijsers RGM

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate...

journal_title：EJNMMI research

authors： Anizan N,Carlier T,Hindorf C,Barbet J,Bardiès M

更新日期：2012-02-13 00:00:00

abstract：BACKGROUND:PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prosta...

journal_title：EJNMMI research

authors： Lake ST,Greene KL,Westphalen AC,Behr SC,Zagoria R,Small EJ,Carroll PR,Hope TA

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...

journal_title：EJNMMI research

authors： Shalgunov V,Xiong M,L'Estrade ET,Raval NR,Andersen IV,Edgar FG,Speth NR,Baerentzen SL,Hansen HD,Donovan LL,Nasser A,Peitersen ST,Kjaer A,Knudsen GM,Syvänen S,Palner M,Herth MM

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor ...

journal_title：EJNMMI research

authors： Bosnyák E,Kamson DO,Behen ME,Barger GR,Mittal S,Juhász C

更新日期：2015-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：EJNMMI research

authors： Ross MI,Bird N,Mendichovszky IA,Rimmer YL

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...

journal_title：EJNMMI research

authors： Morooka M,Moroi M,Uno K,Ito K,Wu J,Nakagawa T,Kubota K,Minamimoto R,Miyata Y,Okasaki M,Okazaki O,Yamada Y,Yamaguchi T,Hiroe M

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...

journal_title：EJNMMI research

authors： Ringheim A,Campos Neto GC,Anazodo U,Cui L,da Cunha ML,Vitor T,Martins KM,Miranda ACC,de Barboza MF,Fuscaldi LL,Lemos GC,Colombo Junior JR,Baroni RH

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

journal_title：EJNMMI research

authors： Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab'-fragment directed against TNF. A biodistribution and do...

journal_title：EJNMMI research

authors： Lambert B,Carron P,D'Asseler Y,Bacher K,Van den Bosch F,Elewaut D,Verbruggen G,Beyaert R,Dumolyn C,De Vos F

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:Pathological complete response to the neoadjuvant therapy (NAT) for triple negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early evaluation of NAT efficiency are still needed, in order to rapidly adjust the therapeutic strategy in case of initial non-response. One option f...

journal_title：EJNMMI research

authors： Jouberton E,Schmitt S,Chautard E,Maisonial-Besset A,Roy M,Radosevic-Robin N,Chezal JM,Miot-Noirault E,Bouvet Y,Cachin F

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...

journal_title：EJNMMI research

authors： Walker MD,Dinelle K,Kornelsen R,Lee A,Farrer MJ,Stoessl AJ,Sossi V

更新日期：2013-10-02 00:00:00

abstract：BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...

journal_title：EJNMMI research

authors： Barrefelt AA,Brismar TB,Egri G,Aspelin P,Olsson A,Oddo L,Margheritelli S,Caidahl K,Paradossi G,Dähne L,Axelsson R,Hassan M

更新日期：2013-02-25 00:00:00

abstract：BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have impleme...

journal_title：EJNMMI research

authors： Spangler-Bickell MG,de Laat B,Fulton R,Bormans G,Nuyts J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...

journal_title：EJNMMI research

authors： Elekonawo FMK,Lütje S,Franssen GM,Bos DL,Goldenberg DM,Boerman OC,Rijpkema M

更新日期：2019-09-04 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...

journal_title：EJNMMI research

authors： Wu WJ,Li ZY,Dong S,Liu SM,Zheng L,Huang MW,Zhang JG

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

journal_title：EJNMMI research

authors： Pérez-Carro R,Cauli O,López-Larrubia P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improv...

journal_title：EJNMMI research

authors： Braat MNGJA,de Jong HW,Seinstra BA,Scholten MV,van den Bosch MAAJ,Lam MGEH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...

journal_title：EJNMMI research

authors： Martic-Kehl MI,Ametamey SM,Alf MF,Schubiger PA,Honer M

更新日期：2012-06-09 00:00:00

abstract：BACKGROUND:The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS:The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand bindi...

journal_title：EJNMMI research

authors： Jahan M,Johnström P,Selvaraju RK,Svedberg M,Winzell MS,Bernström J,Kingston L,Schou M,Jia Z,Skrtic S,Johansson L,Korsgren O,Farde L,Halldin C,Eriksson O

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...

journal_title：EJNMMI research

authors： De Bruycker S,Vangestel C,Staelens S,Wyffels L,Detrez J,Verschuuren M,De Vos WH,Pauwels P,Van den Wyngaert T,Stroobants S

更新日期：2019-08-02 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...

journal_title：EJNMMI research

authors： Taki J,Inaki A,Wakabayashi H,Matsunari I,Imanaka-Yoshida K,Ogawa K,Hiroe M,Shiba K,Yoshida T,Kinuya S

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...

journal_title：EJNMMI research

authors： O'Neill AS,Terry SY,Brown K,Meader L,Wong AM,Cooper JD,Crocker PR,Wong W,Mullen GE

更新日期：2015-12-01 00:00:00