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A novel partial volume correction method for accurate quantification of [18F] flortaucipir in the hippocampus.

Abstract：

BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortaucipir dynamic PET scans (10 probable AD and 10 controls). Volumes of interest (VOIs) were defined for both hippocampus and CP. The correlation between hippocampal and CP distribution volume (VT), with and without PVC, was determined. Both anatomically defined and eroded VOIs were used. RESULTS:For controls, the correlation between hippocampal and CP VT was significantly reduced after using PVC along with an eroded VOI (r2 = 0.59, slope = 0.80 versus r2 = 0.15, slope = 0.15; difference: p < 0.05). The same was true for AD patients (p < 0.05). CONCLUSION:PVC together with an optimized hippocampal VOI resulted in effective reduction of CP spill-in and improved accuracy of hippocampal VT.

journal_name

EJNMMI Res

journal_title

EJNMMI research

authors

Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

doi

10.1186/s13550-018-0432-2

subject

Has Abstract

pub_date

2018-08-15 00:00:00

pages

79

issue

1

issn

2191-219X

pii

10.1186/s13550-018-0432-2

journal_volume

8

pub_type

杂志文章

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