Gut microbiota and physiologic bowel 18F-FDG uptake.

abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

journal_title：EJNMMI research

authors： Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...

journal_title：EJNMMI research

authors： Schaefferkoetter JD,Wang Z,Stephenson MC,Roy S,Conti M,Eriksson L,Townsend DW,Thamboo T,Chiong E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...

journal_title：EJNMMI research

authors： Gnesin S,Cicone F,Mitsakis P,Van der Gucht A,Baechler S,Miralbell R,Garibotto V,Zilli T,Prior JO

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...

journal_title：EJNMMI research

authors： Malherbe ST,Chen RY,Dupont P,Kant I,Kriel M,Loxton AG,Smith B,Beltran CGG,van Zyl S,McAnda S,Abrahams C,Maasdorp E,Doruyter A,Via LE,Barry CE 3rd,Alland D,Richards SG,Ellman A,Peppard T,Belisle J,Tromp G,Ronache

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...

journal_title：EJNMMI research

authors： Taki J,Inaki A,Wakabayashi H,Matsunari I,Imanaka-Yoshida K,Ogawa K,Hiroe M,Shiba K,Yoshida T,Kinuya S

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...

journal_title：EJNMMI research

authors： Kaxiras A,Yamamoto S,Söderdahl G,Wernerson A,Axelsson R,Ericzon BG

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...

journal_title：EJNMMI research

authors： Owaki Y,Nakahara T,Kosaka T,Fukada J,Kumabe A,Ichimura A,Murakami M,Nakajima K,Fukushi M,Inoue K,Oya M,Jinzaki M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in pa...

journal_title：EJNMMI research

authors： O'Donoghue JA,Guillem JG,Schöder H,Lee NY,Divgi CR,Ruby JA,Humm JL,Lee-Kong SA,Burnazi EM,Cai S,Carlin SD,Leibold T,Zanzonico PB,Ling CC

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) have experienced a tremendous boost in the last decade, where more than 15 small molecule TKIs have been approved by the FDA. Unfortunately, despite their promising clinical successes, a large portion of patients remain unresponsive to these targeted drugs. For non-small cel...

journal_title：EJNMMI research

authors： Slobbe P,Windhorst AD,Stigter-van Walsum M,Smit EF,Niessen HG,Solca F,Stehle G,van Dongen GA,Poot AJ

更新日期：2015-03-20 00:00:00

abstract：BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...

journal_title：EJNMMI research

authors： Kanazawa M,Nishiyama S,Hashimoto F,Kakiuchi T,Tsukada H

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

journal_title：EJNMMI research

authors： Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor ...

journal_title：EJNMMI research

authors： Bosnyák E,Kamson DO,Behen ME,Barger GR,Mittal S,Juhász C

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...

journal_title：EJNMMI research

authors： Derwael C,Lavergne O,Lovinfosse P,Nechifor V,Salvé M,Waltregny D,Hustinx R,Withofs N

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse DOTA-linker systems were con...

journal_title：EJNMMI research

authors： Eppard E,de la Fuente A,Mohr N,Allmeroth M,Zentel R,Miederer M,Pektor S,Rösch F

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...

journal_title：EJNMMI research

authors： Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...

journal_title：EJNMMI research

authors： Pfaff S,Nehring T,Pichler V,Cardinale J,Mitterhauser M,Hacker M,Wadsak W

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate...

journal_title：EJNMMI research

authors： Anizan N,Carlier T,Hindorf C,Barbet J,Bardiès M

更新日期：2012-02-13 00:00:00

abstract：BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...

journal_title：EJNMMI research

authors： Kuten J,Dekalo S,Mintz I,Yossepowitch O,Mano R,Even-Sapir E

更新日期：2021-01-06 00:00:00

abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

journal_title：EJNMMI research

authors： Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targetin...

journal_title：EJNMMI research

authors： Erlandsson A,Forssell-Aronsson E,Seidal T,Bernhardt P

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of 99mTc ...

journal_title：EJNMMI research

authors： O'Connor MK,Morrow MMB,Hunt KN,Boughey JC,Wahner-Roedler DL,Conners AL,Rhodes DJ,Hruska CB

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...

journal_title：EJNMMI research

authors： Brix G,Günther E,Rössler U,Endesfelder D,Kamp A,Beer A,Eiber M

更新日期：2020-04-28 00:00:00

abstract：UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...

journal_title：EJNMMI research

authors： Wu C,Gratama van Andel HA,Laverman P,Boerman OC,Beekman FJ

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...

journal_title：EJNMMI research

authors： Boswijk E,Franssen R,Vijgen GHEJ,Wierts R,van der Pol JAJ,Mingels AMA,Cornips EMJ,Majoie MHJM,van Marken Lichtenbelt WD,Mottaghy FM,Wildberger JE,Bucerius J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anat...

journal_title：EJNMMI research

authors： Werner P,Rullmann M,Bresch A,Tiepolt S,Jochimsen T,Lobsien D,Schroeter ML,Sabri O,Barthel H

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

journal_title：EJNMMI research

authors： Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

更新日期：2019-02-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：EJNMMI research

authors： Ross MI,Bird N,Mendichovszky IA,Rimmer YL

更新日期：2020-10-27 00:00:00

abstract：PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

journal_title：EJNMMI research

authors： Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing exp...

journal_title：EJNMMI research

authors： van Aalst J,Ceccarini J,Schramm G,Van Weehaeghe D,Rezaei A,Demyttenaere K,Sunaert S,Van Laere K

更新日期：2020-05-14 00:00:00