Development and evaluation of a rapid analysis for HEPES determination in 68Ga-radiotracers.

abstract：BACKGROUND:Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognost...

journal_title：EJNMMI research

authors： Reza M,Bjartell A,Ohlsson M,Kaboteh R,Wollmer P,Edenbrandt L,Trägårdh E

更新日期：2014-10-17 00:00:00

abstract：BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...

journal_title：EJNMMI research

authors： Dalmo J,Westberg E,Barregard L,Svedbom L,Johansson M,Törnqvist M,Forssell-Aronsson E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

journal_title：EJNMMI research

authors： Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...

journal_title：EJNMMI research

authors： Schimmelpennink MC,Vorselaars ADM,Veltkamp M,Keijsers RGM

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...

journal_title：EJNMMI research

authors： Owaki Y,Nakahara T,Kosaka T,Fukada J,Kumabe A,Ichimura A,Murakami M,Nakajima K,Fukushi M,Inoue K,Oya M,Jinzaki M

更新日期：2017-10-03 00:00:00

abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

journal_title：EJNMMI research

authors： Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...

journal_title：EJNMMI research

authors： Lankinen P,Lehtimäki K,Hakanen AJ,Roivainen A,Aro HT

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

journal_title：EJNMMI research

authors： Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...

journal_title：EJNMMI research

authors： Ter Voert EEGW,Muehlematter UJ,Delso G,Pizzuto DA,Müller J,Nagel HW,Burger IA

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in pa...

journal_title：EJNMMI research

authors： O'Donoghue JA,Guillem JG,Schöder H,Lee NY,Divgi CR,Ruby JA,Humm JL,Lee-Kong SA,Burnazi EM,Cai S,Carlin SD,Leibold T,Zanzonico PB,Ling CC

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...

journal_title：EJNMMI research

authors： Schaefferkoetter JD,Wang Z,Stephenson MC,Roy S,Conti M,Eriksson L,Townsend DW,Thamboo T,Chiong E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...

journal_title：EJNMMI research

authors： De Bruycker S,Vangestel C,Staelens S,Wyffels L,Detrez J,Verschuuren M,De Vos WH,Pauwels P,Van den Wyngaert T,Stroobants S

更新日期：2019-08-02 00:00:00

abstract：BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...

journal_title：EJNMMI research

authors： Barrefelt AA,Brismar TB,Egri G,Aspelin P,Olsson A,Oddo L,Margheritelli S,Caidahl K,Paradossi G,Dähne L,Axelsson R,Hassan M

更新日期：2013-02-25 00:00:00

abstract：BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...

journal_title：EJNMMI research

authors： Lindberg A,Arakawa R,Nogami T,Nag S,Schou M,Elmore CS,Farde L,Pike VW,Halldin C

更新日期：2019-11-21 00:00:00

abstract：:Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-...

journal_title：EJNMMI research

authors： Fujita M,Kobayashi M,Ikawa M,Gunn RN,Rabiner EA,Owen DR,Zoghbi SS,Haskali MB,Telu S,Pike VW,Innis RB

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

journal_title：EJNMMI research

authors： Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...

journal_title：EJNMMI research

authors： Wu WJ,Li ZY,Dong S,Liu SM,Zheng L,Huang MW,Zhang JG

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

journal_title：EJNMMI research

authors： Pérez-Carro R,Cauli O,López-Larrubia P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...

journal_title：EJNMMI research

authors： Morooka M,Moroi M,Uno K,Ito K,Wu J,Nakagawa T,Kubota K,Minamimoto R,Miyata Y,Okasaki M,Okazaki O,Yamada Y,Yamaguchi T,Hiroe M

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...

journal_title：EJNMMI research

authors： Kanazawa M,Nishiyama S,Hashimoto F,Kakiuchi T,Tsukada H

更新日期：2018-06-13 00:00:00

abstract：PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

journal_title：EJNMMI research

authors： Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:[11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by optimizing the timing of initiation of the scan and applying correction to the plasma concentrati...

journal_title：EJNMMI research

authors： Isohashi K,Shimosegawa E,Kato H,Kanai Y,Naka S,Fujino K,Watabe H,Hatazawa J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[18F...

journal_title：EJNMMI research

authors： Ogawa T,Kawai N,Miyake K,Shinomiya A,Yamamoto Y,Nishiyama Y,Tamiya T

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...

journal_title：EJNMMI research

authors： Gnesin S,Cicone F,Mitsakis P,Van der Gucht A,Baechler S,Miralbell R,Garibotto V,Zilli T,Prior JO

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...

journal_title：EJNMMI research

authors： Dalmo J,Spetz J,Montelius M,Langen B,Arvidsson Y,Johansson H,Parris TZ,Helou K,Wängberg B,Nilsson O,Ljungberg M,Forssell-Aronsson E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...

journal_title：EJNMMI research

authors： Suzuki C,Kosugi M,Magata Y

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...

journal_title：EJNMMI research

authors： Martic-Kehl MI,Ametamey SM,Alf MF,Schubiger PA,Honer M

更新日期：2012-06-09 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...

journal_title：EJNMMI research

authors： Brix G,Günther E,Rössler U,Endesfelder D,Kamp A,Beer A,Eiber M

更新日期：2020-04-28 00:00:00