Impact of attenuation correction on clinical [(18)F]FDG brain PET in combined PET/MRI.

abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...

journal_title：EJNMMI research

authors： Martic-Kehl MI,Ametamey SM,Alf MF,Schubiger PA,Honer M

更新日期：2012-06-09 00:00:00

abstract：BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...

journal_title：EJNMMI research

authors： Dalmo J,Westberg E,Barregard L,Svedbom L,Johansson M,Törnqvist M,Forssell-Aronsson E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising modality for detecting active lesions of cardiac sarcoidosis (CS). However, determining whether 18F-FDG uptake in the myocardium is physiological is challenging due to metabolic shift in myocardial cells. Although methods for inhibi...

journal_title：EJNMMI research

authors： Morooka M,Moroi M,Uno K,Ito K,Wu J,Nakagawa T,Kubota K,Minamimoto R,Miyata Y,Okasaki M,Okazaki O,Yamada Y,Yamaguchi T,Hiroe M

更新日期：2014-01-02 00:00:00

abstract：UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...

journal_title：EJNMMI research

authors： Pitkonen M,Hippeläinen E,Raki M,Andressoo JO,Urtti A,Männistö PT,Savolainen S,Saarma M,Bergström K

更新日期：2012-09-29 00:00:00

abstract：BACKGROUND:Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards competition from another agonist,...

journal_title：EJNMMI research

authors： Lindberg A,Arakawa R,Nogami T,Nag S,Schou M,Elmore CS,Farde L,Pike VW,Halldin C

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targetin...

journal_title：EJNMMI research

authors： Erlandsson A,Forssell-Aronsson E,Seidal T,Bernhardt P

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...

journal_title：EJNMMI research

authors： Taralli S,Sollini M,Milella M,Perotti G,Filice A,Menga M,Versari A,Rufini V

更新日期：2018-07-21 00:00:00

abstract：INTRODUCTION:The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. METHODS:For 20 existing [18F]GE-179 datasets, we generated (1) standardised uptake values (SUVs) o...

journal_title：EJNMMI research

authors： McGinnity CJ,Riaño Barros DA,Trigg W,Brooks DJ,Hinz R,Duncan JS,Koepp MJ,Hammers A

更新日期：2018-06-11 00:00:00

abstract：BACKGROUND:Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows ...

journal_title：EJNMMI research

authors： Gustafsson J,Sundlöv A,Sjögreen Gleisner K

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...

journal_title：EJNMMI research

authors： Zacho HD,Ravn S,Afshar-Oromieh A,Fledelius J,Ejlersen JA,Petersen LJ

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examin...

journal_title：EJNMMI research

authors： Bak-Fredslund KP,Lykke Eriksen P,Munk OL,Villadsen GE,Keiding S,Sørensen M

更新日期：2017-08-29 00:00:00

abstract：UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...

journal_title：EJNMMI research

authors： Wu C,Gratama van Andel HA,Laverman P,Boerman OC,Beekman FJ

更新日期：2013-01-31 00:00:00

abstract：BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...

journal_title：EJNMMI research

authors： Malherbe ST,Chen RY,Dupont P,Kant I,Kriel M,Loxton AG,Smith B,Beltran CGG,van Zyl S,McAnda S,Abrahams C,Maasdorp E,Doruyter A,Via LE,Barry CE 3rd,Alland D,Richards SG,Ellman A,Peppard T,Belisle J,Tromp G,Ronache

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:HEPES is a favorable buffer for 68Ga-complexations in radiochemical laboratories. The drawback of this buffer is its prescribed limit of 200 μg per recommended application volume in the final formulation. Currently, a TLC test according to the European Pharmacopoeia (Ph. Eur.) has to be performed for quantif...

journal_title：EJNMMI research

authors： Pfaff S,Nehring T,Pichler V,Cardinale J,Mitterhauser M,Hacker M,Wadsak W

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...

journal_title：EJNMMI research

authors： Walker MD,Dinelle K,Kornelsen R,Lee A,Farrer MJ,Stoessl AJ,Sossi V

更新日期：2013-10-02 00:00:00

abstract：:Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease...

journal_title：EJNMMI research

authors： McBride WJ,Sharkey RM,Goldenberg DM

更新日期：2013-05-08 00:00:00

abstract：BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

journal_title：EJNMMI research

authors： Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The molecular features of isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status have pivotal role for differentiating gliomas and have been integrated in the World Health Organization (WHO) classification in 2016. Positron emission tomography (PET) with 3'-deoxy-3'-[18F...

journal_title：EJNMMI research

authors： Ogawa T,Kawai N,Miyake K,Shinomiya A,Yamamoto Y,Nishiyama Y,Tamiya T

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemic...

journal_title：EJNMMI research

authors： Loveless CS,Radford LL,Ferran SJ,Queern SL,Shepherd MR,Lapi SE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:In the present study, we used multimodal imaging to investigate biodistribution in rats after intravenous administration of a new 99mTc-labeled delivery system consisting of polymer-shelled microbubbles (MBs) functionalized with diethylenetriaminepentaacetic acid (DTPA), thiolated poly(methacrylic acid) (PMA...

journal_title：EJNMMI research

authors： Barrefelt AA,Brismar TB,Egri G,Aspelin P,Olsson A,Oddo L,Margheritelli S,Caidahl K,Paradossi G,Dähne L,Axelsson R,Hassan M

更新日期：2013-02-25 00:00:00

abstract：BACKGROUND:Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (CZP), a commercially available humanized Fab'-fragment directed against TNF. A biodistribution and do...

journal_title：EJNMMI research

authors： Lambert B,Carron P,D'Asseler Y,Bacher K,Van den Bosch F,Elewaut D,Verbruggen G,Beyaert R,Dumolyn C,De Vos F

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...

journal_title：EJNMMI research

authors： Alhuseinalkhudhur A,Lubberink M,Lindman H,Tolmachev V,Frejd FY,Feldwisch J,Velikyan I,Sörensen J

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...

journal_title：EJNMMI research

authors： O'Neill AS,Terry SY,Brown K,Meader L,Wong AM,Cooper JD,Crocker PR,Wong W,Mullen GE

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in pa...

journal_title：EJNMMI research

authors： O'Donoghue JA,Guillem JG,Schöder H,Lee NY,Divgi CR,Ruby JA,Humm JL,Lee-Kong SA,Burnazi EM,Cai S,Carlin SD,Leibold T,Zanzonico PB,Ling CC

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-limiting nephrotoxicity due to radiopeptide retention in the proximal tubules. Pharmacological pr...

journal_title：EJNMMI research

authors： Chan HS,Konijnenberg MW,Daniels T,Nysus M,Makvandi M,de Blois E,Breeman WA,Atcher RW,de Jong M,Norenberg JP

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...

journal_title：EJNMMI research

authors： Owaki Y,Nakahara T,Kosaka T,Fukada J,Kumabe A,Ichimura A,Murakami M,Nakajima K,Fukushi M,Inoue K,Oya M,Jinzaki M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...

journal_title：EJNMMI research

authors： Johnson LL,Johnson J,Ali Z,Tekabe Y,Ober R,Geist G,McLuckie A,Safarov A,Holland A,Zhang G,Backer M,Backer J

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear u...

journal_title：EJNMMI research

authors： Amor D,Goutal S,Marie S,Caillé F,Bauer M,Langer O,Auvity S,Tournier N

更新日期：2018-08-16 00:00:00

abstract：BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...

journal_title：EJNMMI research

authors： Kanazawa M,Nishiyama S,Hashimoto F,Kakiuchi T,Tsukada H

更新日期：2018-06-13 00:00:00