Assessment of regional pulmonary blood flow using 68Ga-DOTA PET.

abstract：BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic ...

journal_title：EJNMMI research

authors： Malviya G,Patel R,Salji M,Martinez RS,Repiscak P,Mui E,Champion S,Mrowinska A,Johnson E,AlRasheedi M,Pimlott S,Lewis D,Leung HY

更新日期：2020-11-25 00:00:00

abstract：:Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four 11C-labeled ligands-(R)-PK11195, PBR28, DPA-713, and ER176-to quantify TSPO in healthy humans. For all of these ligands, BP ND (specific-...

journal_title：EJNMMI research

authors： Fujita M,Kobayashi M,Ikawa M,Gunn RN,Rabiner EA,Owen DR,Zoghbi SS,Haskali MB,Telu S,Pike VW,Innis RB

更新日期：2017-10-16 00:00:00

abstract：BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...

journal_title：EJNMMI research

authors： Akamatsu G,Ikari Y,Ohnishi A,Matsumoto K,Nishida H,Yamamoto Y,Senda M,Japanese Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...

journal_title：EJNMMI research

authors： Kuten J,Dekalo S,Mintz I,Yossepowitch O,Mano R,Even-Sapir E

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...

journal_title：EJNMMI research

authors： Boswijk E,Franssen R,Vijgen GHEJ,Wierts R,van der Pol JAJ,Mingels AMA,Cornips EMJ,Majoie MHJM,van Marken Lichtenbelt WD,Mottaghy FM,Wildberger JE,Bucerius J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...

journal_title：EJNMMI research

authors： Elekonawo FMK,Lütje S,Franssen GM,Bos DL,Goldenberg DM,Boerman OC,Rijpkema M

更新日期：2019-09-04 00:00:00

abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

journal_title：EJNMMI research

authors： Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) (Cancer Res. 73:12-8, 2013). Moreover, the combination th...

journal_title：EJNMMI research

authors： Bison SM,Pool SE,Koelewijn SJ,van der Graaf LM,Groen HC,Melis M,de Jong M

更新日期：2014-05-30 00:00:00

abstract：BACKGROUND:Hypoxia within solid tumors confers radiation resistance and a poorer prognosis. 124I-iodoazomycin galactopyranoside (124I-IAZGP) has shown promise as a hypoxia radiotracer in animal models. We performed a clinical study to evaluate the safety, biodistribution, and imaging characteristics of 124I-IAZGP in pa...

journal_title：EJNMMI research

authors： O'Donoghue JA,Guillem JG,Schöder H,Lee NY,Divgi CR,Ruby JA,Humm JL,Lee-Kong SA,Burnazi EM,Cai S,Carlin SD,Leibold T,Zanzonico PB,Ling CC

更新日期：2013-06-03 00:00:00

abstract：BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...

journal_title：EJNMMI research

authors： Gnesin S,Cicone F,Mitsakis P,Van der Gucht A,Baechler S,Miralbell R,Garibotto V,Zilli T,Prior JO

更新日期：2018-12-12 00:00:00

abstract：:Targeted agents are increasingly used for treating cancer and other diseases, but patients may need to be carefully selected to maximize the potential for therapeutic benefit. One way to select patients is to bind an imaging radionuclide to a targeting agent of interest, so that its uptake in specific sites of disease...

journal_title：EJNMMI research

authors： McBride WJ,Sharkey RM,Goldenberg DM

更新日期：2013-05-08 00:00:00

abstract：UNLABELLED: BACKGROUND:Iodine-123-β-CIT, a single-photon emission computed tomography (SPECT) ligand for dopamine transporters (DATs), has been used for in vivo studies in humans, monkeys, and rats but has not yet been used extensively in mice. To validate the imaging and analysis methods for preclinical DAT imaging, ...

journal_title：EJNMMI research

authors： Pitkonen M,Hippeläinen E,Raki M,Andressoo JO,Urtti A,Männistö PT,Savolainen S,Saarma M,Bergström K

更新日期：2012-09-29 00:00:00

abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

journal_title：EJNMMI research

authors： Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

更新日期：2014-12-01 00:00:00

abstract：:Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis and therapy of diseas...

journal_title：EJNMMI research

authors： Bao G,Tang M,Zhao J,Zhu X

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...

journal_title：EJNMMI research

authors： De Bruycker S,Vangestel C,Staelens S,Wyffels L,Detrez J,Verschuuren M,De Vos WH,Pauwels P,Van den Wyngaert T,Stroobants S

更新日期：2019-08-02 00:00:00

abstract：BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...

journal_title：EJNMMI research

authors： Kaxiras A,Yamamoto S,Söderdahl G,Wernerson A,Axelsson R,Ericzon BG

更新日期：2014-12-01 00:00:00

abstract：: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...

journal_title：EJNMMI research

authors： Moncayo R

更新日期：2011-07-26 00:00:00

abstract：BACKGROUND:Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targetin...

journal_title：EJNMMI research

authors： Erlandsson A,Forssell-Aronsson E,Seidal T,Bernhardt P

更新日期：2011-08-26 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...

journal_title：EJNMMI research

authors： Taralli S,Sollini M,Milella M,Perotti G,Filice A,Menga M,Versari A,Rufini V

更新日期：2018-07-21 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...

journal_title：EJNMMI research

authors： Schimmelpennink MC,Vorselaars ADM,Veltkamp M,Keijsers RGM

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...

journal_title：EJNMMI research

authors： Ter Voert EEGW,Muehlematter UJ,Delso G,Pizzuto DA,Müller J,Nagel HW,Burger IA

更新日期：2018-07-27 00:00:00

abstract：BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have impleme...

journal_title：EJNMMI research

authors： Spangler-Bickell MG,de Laat B,Fulton R,Bormans G,Nuyts J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...

journal_title：EJNMMI research

authors： Kanazawa M,Nishiyama S,Hashimoto F,Kakiuchi T,Tsukada H

更新日期：2018-06-13 00:00:00

abstract：UNLABELLED: BACKGROUND:An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung...

journal_title：EJNMMI research

authors： Gibney BC,Park MA,Chamoto K,Ysasi A,Konerding MA,Tsuda A,Mentzer SJ

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Noninvasive multimodality imaging is essential for preclinical evaluation of the biodistribution and pharmacokinetics of radionuclide therapy and for monitoring tumor response. Imaging with nonstandard positron-emission tomography [PET] isotopes such as 124I is promising in that context but requires accurate...

journal_title：EJNMMI research

authors： Anizan N,Carlier T,Hindorf C,Barbet J,Bardiès M

更新日期：2012-02-13 00:00:00

abstract：BACKGROUND:Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor ...

journal_title：EJNMMI research

authors： Bosnyák E,Kamson DO,Behen ME,Barger GR,Mittal S,Juhász C

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of 99mTc ...

journal_title：EJNMMI research

authors： O'Connor MK,Morrow MMB,Hunt KN,Boughey JC,Wahner-Roedler DL,Conners AL,Rhodes DJ,Hruska CB

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:In molecular imaging and nuclear medicine, theranostic agents that integrate radionuclide pairs are successfully being used for individualized care, which has led to rapidly growing interest in their continued development. These compounds, which are radiolabeled with one radionuclide for imaging and a chemic...

journal_title：EJNMMI research

authors： Loveless CS,Radford LL,Ferran SJ,Queern SL,Shepherd MR,Lapi SE

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...

journal_title：EJNMMI research

authors： Degtiarova G,Claus P,Duchenne J,Cvijic M,Schramm G,Nuyts J,Voigt JU,Gheysens O

更新日期：2019-12-09 00:00:00