Abstract:
BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have implemented a protocol for tracking the rigid motion of the head of a fully conscious rat during a PET scan and performing a motion compensated list-mode reconstruction of the data. Using this technique we have conducted eight rat studies to investigate the effect of isoflurane on the uptake of 18F-FDG in the brain, by comparing conscious and unconscious scans. RESULTS:Our results indicate that isoflurane significantly decreases the whole brain uptake, as well as decreasing the relative regional FDG uptake in the cortex, diencephalon, and inferior colliculi, while increasing it in the vestibular nuclei. No statistically significant changes in FDG uptake were observed in the cerebellum and striata. CONCLUSION:The applied event-based motion compensation technique allowed for the investigation of the effect of isoflurane on FDG uptake in the rat brain using fully awake and unrestrained rats, scanned dynamically from the moment of injection. A significant effect of the anaesthesia was observed in various regions of the brain.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Spangler-Bickell MG,de Laat B,Fulton R,Bormans G,Nuyts Jdoi
10.1186/s13550-016-0242-3subject
Has Abstractpub_date
2016-12-01 00:00:00pages
86issue
1issn
2191-219Xpii
10.1186/s13550-016-0242-3journal_volume
6pub_type
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