Radiofluorination using aluminum-fluoride (Al18F).

abstract：BACKGROUND:There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic activity after apparent clinical cure. This poses a challenge in quantifying scan-...

journal_title：EJNMMI research

authors： Malherbe ST,Chen RY,Dupont P,Kant I,Kriel M,Loxton AG,Smith B,Beltran CGG,van Zyl S,McAnda S,Abrahams C,Maasdorp E,Doruyter A,Via LE,Barry CE 3rd,Alland D,Richards SG,Ellman A,Peppard T,Belisle J,Tromp G,Ronache

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...

journal_title：EJNMMI research

authors： Lapa C,Werner RA,Bluemel C,Lueckerath K,Muegge DO,Strate A,Haenscheid H,Schirbel A,Allen-Auerbach MS,Bundschuh RA,Buck AK,Herrmann K

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:[11C]methionine (MET) has been used to monitor amino acid metabolism in tumors, the pancreas, liver, and myocardium. The aim of the present study was to standardize [11C]MET positron emission tomography (PET) by optimizing the timing of initiation of the scan and applying correction to the plasma concentrati...

journal_title：EJNMMI research

authors： Isohashi K,Shimosegawa E,Kato H,Kanai Y,Naka S,Fujino K,Watabe H,Hatazawa J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

journal_title：EJNMMI research

authors： Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...

journal_title：EJNMMI research

authors： Schaefferkoetter JD,Wang Z,Stephenson MC,Roy S,Conti M,Eriksson L,Townsend DW,Thamboo T,Chiong E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:In PET/MRI, linear photon attenuation coefficients for attenuation correction (AC) cannot be directly derived, and cortical bone is, so far, usually not considered. This results in an underestimation of the average PET signal in PET/MRI. Recently introduced MR-AC methods predicting bone information from anat...

journal_title：EJNMMI research

authors： Werner P,Rullmann M,Bresch A,Tiepolt S,Jochimsen T,Lobsien D,Schroeter ML,Sabri O,Barthel H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Off-target binding in the choroid plexus (CP) may cause spill-in of the tau PET tracer [18F] flortaucipir into the adjacent hippocampus region. The impact of this spill-in on hippocampal uptake was assessed using a novel partial volume correction method (PVC). METHODS:PVC was performed on 20 [18F] flortauci...

journal_title：EJNMMI research

authors： Wolters EE,Golla SSV,Timmers T,Ossenkoppele R,van der Weijden CWJ,Scheltens P,Schwarte L,Schuit RC,Windhorst AD,Barkhof F,Yaqub M,Lammertsma AA,Boellaard R,van Berckel BNM

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...

journal_title：EJNMMI research

authors： Pérez-Carro R,Cauli O,López-Larrubia P

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer kinetics under study, and the nature of these effects is usually not known. METHOD:We have impleme...

journal_title：EJNMMI research

authors： Spangler-Bickell MG,de Laat B,Fulton R,Bormans G,Nuyts J

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:New therapies to treat diabetic peripheral artery disease (PAD) require target-specific non-invasive imaging modalities to follow efficacy. As a translational study, we performed targeted imaging of receptors for vascular endothelial growth factor (VEGF) in response to anterior femoral artery occlusion (FAO)...

journal_title：EJNMMI research

authors： Johnson LL,Johnson J,Ali Z,Tekabe Y,Ober R,Geist G,McLuckie A,Safarov A,Holland A,Zhang G,Backer M,Backer J

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prosta...

journal_title：EJNMMI research

authors： Lake ST,Greene KL,Westphalen AC,Behr SC,Zagoria R,Small EJ,Carroll PR,Hope TA

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...

journal_title：EJNMMI research

authors： Parent MJ,Cyr M,Aliaga A,Kostikov A,Schirrmacher E,Soucy JP,Mechawar N,Rosa-Neto P,Bedard MA

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate the prognostic value of positron emission tomography (PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose ([18F]FDG) uptake on pretreatment PET/computed tomography (CT) in patients with locally advanced salivary gland carcinoma treated with int...

journal_title：EJNMMI research

authors： Wu WJ,Li ZY,Dong S,Liu SM,Zheng L,Huang MW,Zhang JG

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...

journal_title：EJNMMI research

authors： Owaki Y,Nakahara T,Kosaka T,Fukada J,Kumabe A,Ichimura A,Murakami M,Nakajima K,Fukushi M,Inoue K,Oya M,Jinzaki M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...

journal_title：EJNMMI research

authors： Taralli S,Sollini M,Milella M,Perotti G,Filice A,Menga M,Versari A,Rufini V

更新日期：2018-07-21 00:00:00

abstract：UNLABELLED: BACKGROUND:An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung...

journal_title：EJNMMI research

authors： Gibney BC,Park MA,Chamoto K,Ysasi A,Konerding MA,Tsuda A,Mentzer SJ

更新日期：2012-09-21 00:00:00

abstract：BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...

journal_title：EJNMMI research

authors： Bowen SR,Chapman TR,Borgman J,Miyaoka RS,Kinahan PE,Liou IW,Sandison GA,Vesselle HJ,Nyflot MJ,Apisarnthanarax S

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...

journal_title：EJNMMI research

authors： Martic-Kehl MI,Ametamey SM,Alf MF,Schubiger PA,Honer M

更新日期：2012-06-09 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:We quantified myocardial blood flow with (82)Rb PET using parameters of the generalized Renkin-Crone model estimated from (82)Rb and (15)O-water images reconstructed with time-of-flight and point spread function modeling. Previous estimates of rubidium extraction have used older-generation scanners without t...

journal_title：EJNMMI research

authors： Germino M,Ropchan J,Mulnix T,Fontaine K,Nabulsi N,Ackah E,Feringa H,Sinusas AJ,Liu C,Carson RE

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...

journal_title：EJNMMI research

authors： Taki J,Inaki A,Wakabayashi H,Matsunari I,Imanaka-Yoshida K,Ogawa K,Hiroe M,Shiba K,Yoshida T,Kinuya S

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognost...

journal_title：EJNMMI research

authors： Reza M,Bjartell A,Ohlsson M,Kaboteh R,Wollmer P,Edenbrandt L,Trägårdh E

更新日期：2014-10-17 00:00:00

abstract：PURPOSE:Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent antibody MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), a cell surface protein involved in tumour growth, which is overexpressed in solid tumours, including prostate cancer (PCa). This st...

journal_title：EJNMMI research

authors： Yeh MC,Tse BWC,Fletcher NL,Houston ZH,Lund M,Volpert M,Stewart C,Sokolowski KA,Jeet V,Thurecht KJ,Campbell DH,Walsh BJ,Nelson CC,Russell PJ

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...

journal_title：EJNMMI research

authors： Miyaji N,Miwa K,Tokiwa A,Ichikawa H,Terauchi T,Koizumi M,Onoguchi M

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:Non-small cell lung carcinoma (NSCLC) represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (EGFR). Activating mutations in the tyrosine kinase (TK) domain of the EGFR are detected in 10% to 30% of NSCLC patients, and evidence of their pr...

journal_title：EJNMMI research

authors： Abourbeh G,Itamar B,Salnikov O,Beltsov S,Mishani E

更新日期：2015-02-12 00:00:00

abstract：BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...

journal_title：EJNMMI research

authors： Dalmo J,Westberg E,Barregard L,Svedbom L,Johansson M,Törnqvist M,Forssell-Aronsson E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Image-guided surgery may improve surgical outcome for colorectal cancer patients. Here, we evaluated the feasibility of a pretargeting strategy for multimodal imaging in colorectal cancer using an anti-carcinoembryonic antigen (CEA) x anti-histamine-succinyl-glycine (HSG) bispecific antibody (TF2) in conjunc...

journal_title：EJNMMI research

authors： Elekonawo FMK,Lütje S,Franssen GM,Bos DL,Goldenberg DM,Boerman OC,Rijpkema M

更新日期：2019-09-04 00:00:00

abstract：BACKGROUND:Given the increasing clinical use of PET/MRI, potential risks to patients from simultaneous exposure to ionising radiation and (electro)magnetic fields should be thoroughly investigated as a precaution. With this aim, the genotoxic potential of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and a strong static m...

journal_title：EJNMMI research

authors： Brix G,Günther E,Rössler U,Endesfelder D,Kamp A,Beer A,Eiber M

更新日期：2020-04-28 00:00:00

abstract：BACKGROUND:Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of 99mTc ...

journal_title：EJNMMI research

authors： O'Connor MK,Morrow MMB,Hunt KN,Boughey JC,Wahner-Roedler DL,Conners AL,Rhodes DJ,Hruska CB

更新日期：2017-12-01 00:00:00