Abstract：
UNLABELLED: BACKGROUND:An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung regeneration is largely unknown. METHODS:To determine if murine lung regeneration could be detected in vivo, we studied inbred mice 3, 7, 14, and 21 days after left pneumonectomy. The remaining lung was imaged using microCT as well as the glucose tracer 2-deoxy-2-[18 F]fluoro-d-glucose (18FDG) and positron-emission tomography (PET). Because of the compliance of the murine chest wall, reproducible imaging required orotracheal intubation and pressure-controlled ventilation during scanning. RESULTS:After left pneumonectomy, the right lung progressively enlarged over the first 3 weeks. The cardiac lobe demonstrated the greatest percentage increase in size. Dry weights of the individual lobes largely mirrored the increase in lung volume. PET/CT imaging was used to identify enhanced metabolic activity within the individual lobes. In the cardiac lobe, 18FDG uptake was significantly increased in the day 14 cardiac lobe relative to preoperative values (p < .05). In contrast, the 18FDG uptake in the other three lobes was not statistically significant at any time point. CONCLUSIONS:We conclude that the cardiac lobe is the dominant contributor to compensatory growth after murine pneumonectomy. Further, PET/CT scanning can detect both the volumetric increase and the metabolic changes associated with the regenerative growth in the murine cardiac lobe.
journal_name
EJNMMI Resjournal_title
EJNMMI researchauthors
Gibney BC,Park MA,Chamoto K,Ysasi A,Konerding MA,Tsuda A,Mentzer SJdoi
10.1186/2191-219X-2-48subject
Has Abstractpub_date
2012-09-21 00:00:00pages
48issue
1issn
2191-219Xpii
2191-219X-2-48journal_volume
2pub_type
杂志文章相关文献
EJNMMI Research文献大全abstract：BACKGROUND:Peptide receptor radionuclide therapy (PRRT) is applied in patients with advanced neuroendocrine tumors. Co-infused amino acids (AA) should prevent nephrotoxicity. The aims of this study were to correlate the incidence of AA-induced hyperkalemia (HK) (≥5.0 mmol/l) and to identify predictors of AA-induced sev...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0074-y
更新日期：2014-12-24 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. METHODS:Fifty-four consecutive patients (median age 65 years, 15 females, 39 males) with suspec...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-4-6
更新日期：2014-01-22 00:00:00
abstract：BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-017-0269-0
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-2-26
更新日期：2012-06-09 00:00:00
abstract：BACKGROUND:Cerebral blood flow (CBF) quantitation using technetium-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) generally requires assessment of input function by arterial blood sampling, which would be invasive for small animals. We therefore performed chest dynamic planar imaging, instead of arterial blood sampli...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0375-7
更新日期：2018-03-09 00:00:00
abstract：BACKGROUND:Glioblastoma, the most frequent and aggressive of all astrocytomas, presents a clear predominance in male humans, but the assessment of sexual differences in its tumourigenesis and growth has received little attention so far. In this study, we aim to identify gender-dependent surrogate markers in an animal m...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0044-4
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-0594-6
更新日期：2020-02-24 00:00:00
abstract：BACKGROUND:18F-FDG-PET imaging has emerged as a promising method in the diagnosis of chronic osteomyelitis commonly due to Staphylococcus aureus. The inaccuracy of 18 F-FDG-PET in the detection of periprosthetic joint infections may be related to the predominance of low-virulent S. epidermidis strains as the causative ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-2-41
更新日期：2012-07-23 00:00:00
abstract：BACKGROUND:Yoga is increasingly popular worldwide with several physical and mental benefits, but the underlying neurobiology remains unclear. Whereas many studies have focused on pure meditational aspects, the triad of yoga includes meditation, postures, and breathing. We conducted a cross-sectional study comparing exp...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00636-y
更新日期：2020-05-14 00:00:00
abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0423-3
更新日期：2018-07-21 00:00:00
abstract：PURPOSE:To investigate the added value and diagnostic accuracy of 68Ga-PSMA PET/CT versus bone scintigraphy (BS) for bone metastasis detection at the primary staging of prostate cancer (PCa). METHODS:Inclusion criteria involved consecutive patients with newly diagnosed intermediate- to high-risk PCa, who had undergone...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00618-0
更新日期：2020-04-08 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via the original article. ...
journal_title：EJNMMI research
pub_type： 已发布勘误
doi：10.1186/s13550-020-00719-w
更新日期：2020-10-27 00:00:00
abstract：BACKGROUND:The potential of the D-isomerization of 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) to improve its target tumor to non-target normal brain tissue ratio (TBR) was evaluated in rat brain glioma and compared with those of L- and D-11C-methyl-tyrosine (11C-CMT). The L- or D-isomer of 18F-FBPA was injected int...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0404-6
更新日期：2018-06-13 00:00:00
abstract：BACKGROUND:Two novel methods of image reconstruction, xSPECT Quant (xQ) and xSPECT Bone (xB), that use an ordered subset conjugate gradient minimizer (OSCGM) for SPECT/CT reconstruction have been proposed. The present study compares the performance characteristics of xQ, xB, and conventional Flash3D (F3D) reconstructio...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00659-5
更新日期：2020-06-29 00:00:00
abstract：BACKGROUND:In contrast to ordered subset expectation maximization (OSEM), block sequential regularized expectation maximization (BSREM) positron emission tomography (PET) reconstruction algorithms can run until full convergence while controlling image quality and noise. Recent studies with BSREM and 18F-FDG PET reporte...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0414-4
更新日期：2018-07-27 00:00:00
abstract：BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00745-8
更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:Assessment of liver function is critical in hepatocellular carcinoma (HCC) patient management. We evaluated parameters of [(99m)Tc] sulfur colloid (SC) SPECT/CT liver uptake for association with clinical measures of liver function and outcome in HCC patients. METHODS:Thirty patients with HCC and variable Ch...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0212-9
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of 68Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer posit...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-018-0462-9
更新日期：2018-12-12 00:00:00
abstract：BACKGROUND:Quantification of cerebral blood flow (CBF) is important for the understanding of normal and pathologic brain physiology. Positron emission tomography (PET) with H215O (or C15O2) can quantify CBF and apply kinetic analyses, including autoradiography (ARG) and the basis function methods (BFM). These approache...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-3-41
更新日期：2013-05-23 00:00:00
abstract：BACKGROUND:Hepatobiliary scintigraphy using (99m)Tc-mebrofenin has been used as an investigation to study liver function after liver transplantation (LTx). Hepatic extraction fraction (HEF) is a measurement of the hepatic extraction efficiency and hepatic extraction rate. With the purpose of evaluating a possible diver...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0073-z
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improv...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0248-x
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-0603-9
更新日期：2020-03-23 00:00:00
abstract：BACKGROUND:Previously, we reported on the unexpected development of distant metastases in the subcutaneous rat pancreas CA20948 tumor model after 4.5 weeks of treatment with RAD001-only or in combination with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE) (Cancer Res. 73:12-8, 2013). Moreover, the combination th...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0021-y
更新日期：2014-05-30 00:00:00
abstract：UNLABELLED: BACKGROUND:In single-photon emission computed tomography (SPECT), attenuation of photon flux in tissue affects quantitative accuracy of reconstructed images. Attenuation maps derived from X-ray computed tomography (CT) can be employed for attenuation correction. The attenuation coefficients as well as regi...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-3-7
更新日期：2013-01-31 00:00:00
abstract：BACKGROUND:Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations. Compared to larger ...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-020-00718-x
更新日期：2020-10-19 00:00:00
abstract：BACKGROUND:Fluorine-18 fluoroethoxybenzovesamicol ([18F]FEOBV) is a radioligand for the selective imaging of the vesicular acetylcholine transporter with positron emission tomography (PET). The current study demonstrates that pathological cortical cholinergic deafferentation can be quantified in vivo with [18F]FEOBV PE...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-3-70
更新日期：2013-10-09 00:00:00
abstract：BACKGROUND:[18 F]fluorodopa (FDOPA) positron emission tomography (PET) allows assessment of levodopa (LDOPA) metabolism and is widely used to study Parkinson's disease. We examined how [18 F]FDOPA PET-derived kinetic parameters relate the dopamine (DA) and DA metabolite content of extracellular fluid measured by microd...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-3-69
更新日期：2013-10-02 00:00:00
abstract：BACKGROUND:To combine the sensitivity of bioluminescent imaging (BLI) with the 3D and quantitative properties of pinhole single-photon emission computed tomography (SPECT)/micro-computed tomography (CT) (phSPECT/micro-CT), we generated stable cell lines that express a yellow-fluorescent protein (YFP) and Gaussia lucife...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-014-0032-8
更新日期：2014-06-26 00:00:00
abstract：BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/s13550-016-0247-y
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Small-cell lung carcinoma (SCLC) is an aggressive malignancy characterised by an early relapse, a tendency towards drug resistance, and a high incidence of metastasis. SCLC cells are of neuroendocrine origin and express high levels of somatostatin receptors; therefore, future treatment might involve targetin...
journal_title：EJNMMI research
pub_type： 杂志文章
doi：10.1186/2191-219X-1-19
更新日期：2011-08-26 00:00:00
