Multiparametric PET/CT-perfusion does not add significant additional information for initial staging in lung cancer compared with standard PET/CT.

abstract：BACKGROUND:177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rarely seen, and optimization of treatment protocols is needed. In vitro studies have shown that irradiation can up-regu...

journal_title：EJNMMI research

authors： Dalmo J,Spetz J,Montelius M,Langen B,Arvidsson Y,Johansson H,Parris TZ,Helou K,Wängberg B,Nilsson O,Ljungberg M,Forssell-Aronsson E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor. Currently, 18F-fluoro-deoxy-glucose (18F-FDG) PET/CT is the functional imaging modality of choice. Few data are available on the use of 68Ga-somatostatin analogs. The aim of our study was to evaluate and compare the diagnostic performanc...

journal_title：EJNMMI research

authors： Taralli S,Sollini M,Milella M,Perotti G,Filice A,Menga M,Versari A,Rufini V

更新日期：2018-07-21 00:00:00

abstract：BACKGROUND:Bone Scan Index (BSI) is a quantitative measurement of tumour burden in the skeleton calculated from bone scan images. When analysed at the time of diagnosis, it has been shown to provide prognostic information on survival in men with metastatic prostate cancer (PCa). In this study, we evaluated the prognost...

journal_title：EJNMMI research

authors： Reza M,Bjartell A,Ohlsson M,Kaboteh R,Wollmer P,Edenbrandt L,Trägårdh E

更新日期：2014-10-17 00:00:00

abstract：BACKGROUND:The use of radiolabeled choline as a positron emission tomography (PET) agent for imaging primary tumors in the prostate has been evaluated extensively over the past two decades. There are, however, conflicting reports of its sensitivity and the relationship between choline PET imaging and disease staging is...

journal_title：EJNMMI research

authors： Schaefferkoetter JD,Wang Z,Stephenson MC,Roy S,Conti M,Eriksson L,Townsend DW,Thamboo T,Chiong E

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:To assess 18-fluorodeoxyglucose (FDG) bowel uptake in patients with differentiated thyroid cancer (DTC) treated with sorafenib. FINDINGS:Visual (5-point scale) and high maximum standard uptake value (SUVmax) semi-quantitative analyses were conducted in 63 positron emission tomography (PET) studies performed...

journal_title：EJNMMI research

authors： Ciappuccini R,Trzepla G,Heutte N,Sevin E,Galais MP,Bardet S

更新日期：2012-05-07 00:00:00

abstract：BACKGROUND:PET/CT with the radioactively labelled galactose analogue 2-18F-fluoro-2-deoxy-D-galactose (18F-FDGal) can be used to quantify the hepatic metabolic function and visualise regional metabolic heterogeneity. We determined the day-to-day variation in humans with and without liver disease. Furthermore, we examin...

journal_title：EJNMMI research

authors： Bak-Fredslund KP,Lykke Eriksen P,Munk OL,Villadsen GE,Keiding S,Sørensen M

更新日期：2017-08-29 00:00:00

abstract：: The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on thi...

journal_title：EJNMMI research

authors： Moncayo R

更新日期：2011-07-26 00:00:00

abstract：BACKGROUND:We aimed to determine the accuracy of laser Doppler perfusion imaging (LDPI) in an animal model for hind limb ischemia. METHODS:We used a murine (C57Bl/6 mice) ischemic hind limb model in which we compared LDPI with the clinically used (99m)Tc-sestamibi SPECT perfusion imaging (n = 7). In addition, we used ...

journal_title：EJNMMI research

authors： Hendrikx G,Vries MH,Bauwens M,De Saint-Hubert M,Wagenaar A,Guillaume J,Boonen L,Post MJ,Mottaghy FM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The biology of the vulnerable plaque includes increased inflammation and rapid growth of vasa vasorum, processes that are associated with enhanced vascular endothelial growth factor (VEGF)/ imaging receptors for VEGF (VEGFR) signaling and are accelerated in diabetes. This study was designed to test the hypot...

journal_title：EJNMMI research

authors： Tekabe Y,Kollaros M,Zerihoun A,Zhang G,Backer MV,Backer JM,Johnson LL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effect of metformin on long-term radiotherapy outcome and we studied the potential o...

journal_title：EJNMMI research

authors： De Bruycker S,Vangestel C,Staelens S,Wyffels L,Detrez J,Verschuuren M,De Vos WH,Pauwels P,Van den Wyngaert T,Stroobants S

更新日期：2019-08-02 00:00:00

abstract：BACKGROUND:Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We t...

journal_title：EJNMMI research

authors： O'Neill AS,Terry SY,Brown K,Meader L,Wong AM,Cooper JD,Crocker PR,Wong W,Mullen GE

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Vagus nerve activation impacts inflammation. Therefore, we hypothesized that vagal nerve stimulation (VNS) influenced arterial wall inflammation as measured by 18F-FDG uptake. RESULTS:Ten patients with left-sided VNS for refractory epilepsy were studied during stimulation (VNS-on) and in the hours after sti...

journal_title：EJNMMI research

authors： Boswijk E,Franssen R,Vijgen GHEJ,Wierts R,van der Pol JAJ,Mingels AMA,Cornips EMJ,Majoie MHJM,van Marken Lichtenbelt WD,Mottaghy FM,Wildberger JE,Bucerius J

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:High expression of human epidermal growth factor receptor type 2 (HER2) represents an aggressive subtype of breast cancer. Anti-HER2 treatment requires a theragnostic approach wherein sufficiently high receptor expression in biopsy material is mandatory. Heterogeneity and discordance of HER2 expression betwe...

journal_title：EJNMMI research

authors： Alhuseinalkhudhur A,Lubberink M,Lindman H,Tolmachev V,Frejd FY,Feldwisch J,Velikyan I,Sörensen J

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:We investigated the association between physiologic bowel FDG uptake and gut microbiota. FDG uptake in the normal large and small intestine is widely variable both in distribution and intensity. The etiology of physiologic bowel 18F-FDG activity remains unknown. RESULTS:We included 63 healthy male subjects....

journal_title：EJNMMI research

authors： Kang JY,Kim HN,Chang Y,Yun Y,Ryu S,Shin H,Kim HL

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated u...

journal_title：EJNMMI research

authors： Velasco C,Mateo J,Santos A,Mota-Cobian A,Herranz F,Pellico J,Mota RA,España S,Ruiz-Cabello J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand. METHODS:The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand bindi...

journal_title：EJNMMI research

authors： Jahan M,Johnström P,Selvaraju RK,Svedberg M,Winzell MS,Bernström J,Kingston L,Schou M,Jia Z,Skrtic S,Johansson L,Korsgren O,Farde L,Halldin C,Eriksson O

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Depression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor ...

journal_title：EJNMMI research

authors： Bosnyák E,Kamson DO,Behen ME,Barger GR,Mittal S,Juhász C

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:We have developed a multi-modal imaging approach for SIRT, combining 99mTc-MAA SPECT/CT and/or 90Y PET, 18F-FDG PET/CT, and contrast-enhanced CBCT for voxel-based dosimetry, as a tool for treatment planning and verification. For radiation dose prediction calculations, a segmentation of the total liver volume an...

journal_title：EJNMMI research

authors： Jafargholi Rangraz E,Coudyzer W,Maleux G,Baete K,Deroose CM,Nuyts J

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Although 68Ga-PSMA-11 PET is widely used in research and clinical practice, full kinetic modeling has not yet been reported ...

journal_title：EJNMMI research

authors： Ringheim A,Campos Neto GC,Anazodo U,Cui L,da Cunha ML,Vitor T,Martins KM,Miranda ACC,de Barboza MF,Fuscaldi LL,Lemos GC,Colombo Junior JR,Baroni RH

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpret...

journal_title：EJNMMI research

authors： Derwael C,Lavergne O,Lovinfosse P,Nechifor V,Salvé M,Waltregny D,Hustinx R,Withofs N

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with (177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each pati...

journal_title：EJNMMI research

authors： Dalmo J,Westberg E,Barregard L,Svedbom L,Johansson M,Törnqvist M,Forssell-Aronsson E

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Amino acid co-infusion for renal protection in endoradiotherapy (ERT) applied as prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) or peptide receptor radionuclide therapy (PRRT) has been shown to cause severe hyperkalemia. The pathophysiology behind the rapid development of hyperk...

journal_title：EJNMMI research

authors： Pfob CH,Eiber M,Luppa P,Maurer F,Maurer T,Tauber R,D'Alessandria C,Feuerecker B,Scheidhauer K,Ott A,Heemann U,Schwaiger M,Schmaderer C

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:18F-FDG PET/CT has proven to be a reliable tool for therapy monitoring in sarcoidosis. Previous PET studies investigated the SUVmax as a marker for disease activity. Total lung glycolysis (TLuG) is a new tool, quantifying the glycolysis of the entire lung. Since SUVmax represents the maximum activity in only...

journal_title：EJNMMI research

authors： Schimmelpennink MC,Vorselaars ADM,Veltkamp M,Keijsers RGM

更新日期：2019-06-13 00:00:00

abstract：BACKGROUND:Assessing the extent of disease in newly diagnosed prostate cancer (PC) patients is crucial for tailoring an appropriate treatment approach. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography/computed tomography (PET/CT) reportedly has greater accuracy than conventional imaging f...

journal_title：EJNMMI research

authors： Kuten J,Dekalo S,Mintz I,Yossepowitch O,Mano R,Even-Sapir E

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. RESULTS:Thirty consecutive non-ischemic...

journal_title：EJNMMI research

authors： Degtiarova G,Claus P,Duchenne J,Cvijic M,Schramm G,Nuyts J,Voigt JU,Gheysens O

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:Image-based measurement of absorbed dose of Ra-223 dichloride may be useful in predicting therapeutic outcome in patients with castration-resistant prostate cancer (CRPC). In general, SPECT has been found to be more accurate than planar imaging in terms of lesion-based analysis. The aims of this study were t...

journal_title：EJNMMI research

authors： Owaki Y,Nakahara T,Kosaka T,Fukada J,Kumabe A,Ichimura A,Murakami M,Nakajima K,Fukushi M,Inoue K,Oya M,Jinzaki M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:We recently showed improved between-subject variability in our [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) experiments using a Michaelis-Menten transport model to calculate the metabolic tumor glucose uptake rate extrapolated to the hypothetical condition of glucose saturation: MRgl...

journal_title：EJNMMI research

authors： Williams SP,Flores-Mercado JE,Baudy AR,Port RE,Bengtsson T

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC), an extracellular matrix glycoprotein, is expressed transiently in distinct areas in association with active tissue remodeling. This study aimed to explore how ischemic postconditioning (PC) affects myocardial expression of TNC and ventricular remodeling using (125)I-labeled anti-TNC antibod...

journal_title：EJNMMI research

authors： Taki J,Inaki A,Wakabayashi H,Matsunari I,Imanaka-Yoshida K,Ogawa K,Hiroe M,Shiba K,Yoshida T,Kinuya S

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Amyloid PET plays a vital role in detecting the accumulation of in vivo amyloid-β (Aβ). The quantification of Aβ accumulation has been widely performed using the region of interest (ROI)-based mean cortical standardized uptake value ratio (mcSUVR). However, voxel-based statistical analysis has not been well ...

journal_title：EJNMMI research

authors： Akamatsu G,Ikari Y,Ohnishi A,Matsumoto K,Nishida H,Yamamoto Y,Senda M,Japanese Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND:Noninvasive preclinical imaging methodologies such as small animal positron emission tomography (PET) allow the repeated measurement of the same subject which is generally assumed to reduce the variability of the experimental outcome parameter and to produce more robust results. In this study, the variabilit...

journal_title：EJNMMI research

authors： Martic-Kehl MI,Ametamey SM,Alf MF,Schubiger PA,Honer M

更新日期：2012-06-09 00:00:00